Patents Assigned to Oxford Gene Technology Limited
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Patent number: 7811751Abstract: This invention provides an apparatus and method for analyzing a polynucleotide sequence, either an unknown sequence or a known sequence. A support carries an array of the whole or a chosen part of a complete set of oligonucleotides, which are capable of taking part in hybridization reactions. The polynucleotide sequence, or fragments thereof, are labeled and applied to the array under hybridizing conditions. Applications include analysis of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.Type: GrantFiled: April 4, 2002Date of Patent: October 12, 2010Assignee: Oxford Gene Technology LimitedInventor: Edwin Southern
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Publication number: 20050032048Abstract: Abstract of the Disclosure This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pairs of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.Type: ApplicationFiled: October 22, 1999Publication date: February 10, 2005Applicant: Oxford Gene Technology LimitedInventor: Edwin Southern
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Publication number: 20050019760Abstract: Abstract of the Disclosure This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pairs of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.Type: ApplicationFiled: October 22, 1999Publication date: January 27, 2005Applicant: Oxford Gene Technology LimitedInventor: Edwin Southern
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Patent number: 6576426Abstract: This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety contains information defining the identify and location of the analyte residues of the analyte moiety which is detectable by mass spectrometry.Type: GrantFiled: December 6, 2001Date of Patent: June 10, 2003Assignee: Oxford Gene Technology LimitedInventors: Edwin Southern, William Jonathan Cummins
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Patent number: 6307039Abstract: A method of analyzing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analyzed. Arrays of immobilised oligonucleotides are provided for use in the method.Type: GrantFiled: February 11, 2000Date of Patent: October 23, 2001Assignee: Oxford Gene Technology LimitedInventors: Edwin Mellor Southern, Clare Elizabeth Pritchard, Stephen Charles Case-Green
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Patent number: 6218111Abstract: This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety contains information defining the identify and location of the analyte residues of the analyte moiety which is detectable by mass spectrometry.Type: GrantFiled: December 10, 1997Date of Patent: April 17, 2001Assignee: Oxford Gene Technology LimitedInventors: Edwin Southern, William Jonathan Cummins
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Patent number: 6150095Abstract: A method of analyzing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analysed. Arrays of immobilised oligonucleotides are provided for use in the method.Type: GrantFiled: October 6, 1997Date of Patent: November 21, 2000Assignee: Oxford Gene Technology LimitedInventors: Edwin Mellor Southern, Clare Elizabeth Pritchard, Stephen Charles Case-Green
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Patent number: 6080585Abstract: A method of identifying one or a combination of ligands, e.g. oligonucleotides or analogues, that interact specifically with a target, e.g. a DNA or an RNA molecule having a secondary or tertiary structure. One ligand may be pre-reacted to open up the target for interaction with other ligands forming an array on a solid surface.Type: GrantFiled: October 2, 1996Date of Patent: June 27, 2000Assignee: Oxford Gene Technology LimitedInventors: Edwin Mellor Southern, Kalim Ullah Mir, Stephen Charles Case-Green
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Patent number: 6054270Abstract: This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pair of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.Type: GrantFiled: September 9, 1997Date of Patent: April 25, 2000Assignee: Oxford Gene Technology LimitedInventor: Edwin Southern
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Patent number: 5770367Abstract: A reagent comprises: a) an analyte moiety comprising at least two analyte residues, and linked to; b) a tag moiety comprising one or more reporter groups adapted for detection by mass spectrometry, wherein a reporter group designates analyte residue, and the reporter group at each position of the tag moiety is chosen to designate an analyte residue at a defined position of the analyte moiety. A plurality of such reagents, each comprising a different analyte moiety, provides a library of reagents which may be used in assay methods involving a target substance. Analysis of the tag moieties indicates the nature of the analyte moieties bound to the target substance. A method of sequencing nucleic acid employs a library of the reagents to determine the sequence of a target nucleic acid.Type: GrantFiled: February 5, 1996Date of Patent: June 23, 1998Assignee: Oxford Gene Technology LimitedInventors: Edwin Southern, William Jonathan Cummins