Patents Assigned to Pacira Pharmaceuticals, Inc.
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Patent number: 8834921Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: GrantFiled: May 21, 2012Date of Patent: September 16, 2014Assignee: Pacira Pharmaceuticals, Inc.Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
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Publication number: 20140004173Abstract: Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.Type: ApplicationFiled: March 8, 2013Publication date: January 2, 2014Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130344132Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: ApplicationFiled: March 15, 2013Publication date: December 26, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130306759Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: November 21, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130209547Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 6, 2013Publication date: August 15, 2013Applicant: PACIRA PHARMACEUTICALS INC.Inventor: PACIRA PHARMACEUTICALS INC
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Publication number: 20130209548Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 6, 2013Publication date: August 15, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130195965Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: August 1, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130189348Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 6, 2013Publication date: July 25, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130189350Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130189349Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.Type: ApplicationFiled: March 6, 2013Publication date: July 25, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130183374Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130183371Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.Type: ApplicationFiled: March 5, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130183375Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 8, 2013Publication date: July 18, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130183370Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.Type: ApplicationFiled: March 5, 2013Publication date: July 18, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130183372Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130183373Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130177636Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 11, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
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Publication number: 20130177638Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130177634Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
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Publication number: 20130177633Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.