Patents Assigned to Panorama Research, Inc.
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Patent number: 11447442Abstract: The present disclosure provides adamantyl compounds having one or more amine groups and one or more nitrate groups. The aminoadamantyl nitrate compounds can be used to treat disorders of the central nervous system, including neurodegenerative and non-neurodegenerative diseases.Type: GrantFiled: November 20, 2018Date of Patent: September 20, 2022Assignee: Panorama Research, Inc.Inventors: Cyrus K. Becker, Meenakshi S. Venkatraman, Xiaoming Zhang, James W. Larrick
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Patent number: 8367720Abstract: The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.Type: GrantFiled: August 7, 2008Date of Patent: February 5, 2013Assignee: Panorama Research Inc.Inventors: Yuqiang Wang, Xiaojian Jiang, Jie Jiang, Zaijun Zhang, Zhaoqi Yang, Pei Yu
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Publication number: 20110077295Abstract: The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.Type: ApplicationFiled: August 7, 2008Publication date: March 31, 2011Applicant: PANORAMA RESEARCH INC.Inventors: Yuqiang Wang, Xiaojian Jiang, Jie Jiang, Zaijun Zhang, Zhaoqi Yang, Pei Yu
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Patent number: 6852889Abstract: The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate; R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R9-R14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.Type: GrantFiled: January 30, 2004Date of Patent: February 8, 2005Assignees: Panorama Research, Inc., NeuroMolecular, Inc.Inventors: Yuqiang Wang, James W. Larrick
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Patent number: 6759416Abstract: The present invention provides novel conjugates of camptothecin compounds and long-chain unsaturated fatty acid. The novel conjugates can be used to treat mammalian cell proliferative diseases such as cancer.Type: GrantFiled: June 9, 2003Date of Patent: July 6, 2004Assignee: Panorama Research, Inc.Inventor: Yuqiang Wang
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Patent number: 6358699Abstract: ADMA is determined in a physiological sample by first removing interfering components: proteins by precipitation; and amines and citrulline, by means of a cation exchange column, followed by enzymatic hydrolysis of the ADMA to citrulline with DDAH. The citrulline is then determined spectrophotometrically.Type: GrantFiled: February 1, 2000Date of Patent: March 19, 2002Assignees: Cooke Pharma, Panorama Research, Inc.Inventors: Robert F. Balint, Mitchell Wayne Mutz, John P. Cooke
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Patent number: 6103888Abstract: Compositions and methods for the treatment and diagnosis of lipopolysaccharide-related conditions and coagulant-related disease are provided. Compositions include polypeptides which are identical or homologous to a certain cationic protein (CAP18) obtained from mammalian granulocytes, particularly including a reactive nitrogen inhibiting peptide (RNIP) fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated activation of macrophage, as well as interfering with the clotting cascade to inhibit coagulation in conditions such as disseminated intravascular coagulation. Compositions comprising the polypeptides in a suitable pharmaceutical carrier are also provided.Type: GrantFiled: June 1, 1999Date of Patent: August 15, 2000Assignee: Panorama Research, Inc.Inventors: James W. Larrick, Susan C. Wright, Michimasa Hirata
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Patent number: 5952189Abstract: A method is disclosed for assaying for inhibitors of a 24 kDa cytoplasmic protease associated with apoptosis. The protease has a defined amino acid composition, activity against the elastase-like substrate MAAVP, and induces DNA fragmentation associated with apoptosis in isolated U937 cell target nuclei.Type: GrantFiled: March 26, 1997Date of Patent: September 14, 1999Assignee: Panorama Research, Inc.Inventors: Susan C. Wright, James W. Larrick
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Patent number: 5843937Abstract: The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomeric constituents are derived from monocyclic or bicyclic heterocyclic aromatic residues.Type: GrantFiled: May 23, 1996Date of Patent: December 1, 1998Assignee: Panorama Research, Inc.Inventors: Yuqiang Wang, Susan C. Wright, James W. Larrick
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Patent number: 5618675Abstract: Compositions and methods for the treatment and diagnosis of lipopolysaccharide-related conditions and coagulant-related disease are provided. Compositions include polypeptides which are identical or homologous to a certain cationic protein (CAP18) obtained from mammalian granulocytes, particularly including a reactive nitrogen inhibiting peptide (RNIP) fragment found at the carboxyl-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated activation of macrophage, as well as interfering with the clotting cascade to inhibit coagulation in conditions such as disseminated intravascular coagulation. Compositions comprising the polypeptides in a suitable pharmaceutical carrier are also provided.Type: GrantFiled: September 27, 1994Date of Patent: April 8, 1997Assignee: Panorama Research, Inc.Inventors: James W. Larrick, Susan C. Wright
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Patent number: 5605826Abstract: An apoptosis-associated protease having a relative mass of 24 kilodaltons and a defined amino acid composition is disclosed, together with a method for its purification from a cytoplasmic extract of mammalian cells treated with an apoptosis-inducing agent, such as tumor necrosis factor-.alpha. or UV irradiation, that comprises affinity chromatography with the serine protease inhibitor DK120 followed by heparin-sepharose chromatography. The protease has activity against the elastase-like substrate MAAPV and is capable of inducing apoptosis in isolated U937 cell target nuclei.Type: GrantFiled: June 10, 1994Date of Patent: February 25, 1997Assignee: Panorama Research, Inc.Inventors: Susan C. Wright, James W. Larrick
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Patent number: 5440022Abstract: A novel human hepatokine, referred to hereinafter as HPX, has been isolated and purified from human fetal hepatocytes. HPX has a molecular weight of approximately 15 kD, a pI of about 6, and has been found to promote hepatocyte growth activity in vitro and in vivo.Type: GrantFiled: October 14, 1992Date of Patent: August 8, 1995Assignee: Panorama Research, Inc.Inventors: Chu-tse Wu, Qiang Tu, Fu-chu He, James W. Larrick