Patents Assigned to Parke, Davis & Company
  • Patent number: 5393804
    Abstract: There is provided a biodegradable composition as obtained from a melt comprising converted starch, a plasticizer and at least one member selected from alkenol homopolymers and/or alkenol copolymers which are combined under conditions sufficient to ensure uniform melt formation, in which the at least one member is present in the composition at a concentration of from 10 to 200 parts per 100 parts of dry converted starch.The invention further relates to methods of making the composition, and to articles made from said composition.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: February 28, 1995
    Assignee: Parke, Davis & Company
    Inventors: Eric George, Eddie Park, Paul A. Altieri, Charles W. Paul
  • Patent number: 4625608
    Abstract: A microtome has a specimen holder which executes a vertical up and down movement relative to a cutting knife and which has a guide mechanism in which a sleeve is arranged so as to be horizontally displaceable. The sleeve is provided at its front end with a specimen clamping mechanism and in its interior with a micrometer nut which is secured against axial displacement and through which extends a micrometer spindle mounted on the guide mechanism. The micrometer nut has on its outer face a toothed ring which is connected operatively to a pinion connected to an electric motor. When the electric motor is activated the sleeve is displaced in the guide mechanism. The micrometer spindle extends, on the side opposite the specimen clamping mechanism, through the guide mechanism as a stub end on which is located a mechanical cutting-thickness advance mechanism.
    Type: Grant
    Filed: January 30, 1985
    Date of Patent: December 2, 1986
    Assignee: Parke, Davis & Company
    Inventors: Werner Behme, Manfred Berleth
  • Patent number: 4598621
    Abstract: A microtome comprises a handwheel which can be rotated in two directions of rotation, and drive means for the purpose of driving a specimen holder, so that the specimen holder executes a cutting movement when the handwheel is rotated in one direction, and a resetting movement when the handwheel is rotated in the other direction. The cutting and resetting movements take place relative to a cutting knife. A reduction gearing arrangement enables the speed of the cutting movement to be reduced relative to the speed of the resetting movement without having to rotate the handwheel at a correspondingly lower rate. A catch enables the reduction gearing arrangement to be bridged so that the speed of the cutting movement and resetting movement are equal for any given rate of rotation of the handwheel.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: July 8, 1986
    Assignee: Parke, Davis & Company
    Inventor: Helmut Weinhold
  • Patent number: 4594929
    Abstract: A microtome provided with a drive wheel mounted in a stand, to be actuated manually and/or by means of a drive motor for generating a vertical relative movement between a specimen holder and a cutting knife, has a specimen holder, having a specimen clamping mechanism, arranged so as to be horizontally displaceable in a vertically drivable guide mechanism by means of a cutting-thickness adjustment mechanismn. The adjustment mechanism can horizontally displace the specimen holder through a cutting thickness adjustment distance towards the cutting knife. A specimen retraction mechanism serves to displace horizontally the specimen holder from an unretracted position to a retracted position, the retracted position being further from the cutting knife than the unretracted position. The distance between the retracted position and the unretracted position is greater than the maximum cutting thickness adjustment distance.
    Type: Grant
    Filed: January 30, 1985
    Date of Patent: June 17, 1986
    Assignee: Parke, Davis & Company
    Inventors: Werner Behme, Manfred Berleth
  • Patent number: 4548051
    Abstract: A cryostat microtome apparatus comprises a cooling enclosure which can be set to a predetermined internal temperature and a microtome disposed in the enclosure. The enclosure is supported on a support assembly which is vertically adjustable to permit stepless adjustment of the height of the enclosure, for adaptation to operator requirements. A mechanical actuating assembly and/or a gas spring assembly is provided for height adjustment of the apparatus.
    Type: Grant
    Filed: February 1, 1983
    Date of Patent: October 22, 1985
    Assignee: Parke, Davis & Company
    Inventor: Gerhard Moessner
  • Patent number: 4502358
    Abstract: A knife holder having two cylinders journaled for axial and rotatable movement are supported by two spaced-apart clamp blocks. The cylinders are axially and rotatably movable in the clamp blocks. Each cylinder has a continuous longitudinal slot of a cross-sectional shape generally complementary to the cross-sectional shape of the knife clamped therein. The axial movement of one cylinder relative to the other cylinder enables the length of knife edge that is exposed to be varied.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: March 5, 1985
    Assignee: Parke, Davis & Company
    Inventor: Werner Behme
  • Patent number: 4382063
    Abstract: A sterility indicator device comprising a base of steam permeable, absorbent material, e.g. paperboard, having mounted thereon at least one, though preferably three separate indicator ink spots of chromium chloride that change color in response to predetermined combinations of time, temperature and saturated steam, impermeable transparent cover films bonded to the top surface of the base overlaying the indicator ink spots and to the bottom surface of the base thereby preventing the escape of corrosive reactants there through, and an adhesive substance, to be used to bond the impermeable cover films to the base.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: May 3, 1983
    Assignee: Parke-Davis Company
    Inventors: Vincent A. Romito, Loran H. Bruso
  • Patent number: 4268265
    Abstract: Process for stabilizing dyestuffs sensitive to light and/or oxidation, especially natural dyestuffs, by adsorption on a highly disperse adsorbent, whereby the dyestuff is immobilized, as well as the application of the process to dyestuffs which are determined for dyeing medicines, for instance gelatine capsules for medicinal purposes, cosmetics, food stuffs and animal feed.
    Type: Grant
    Filed: July 13, 1979
    Date of Patent: May 19, 1981
    Assignee: Parke, Davis & Company
    Inventor: Andre R. Von Wattenwyl
  • Patent number: 4145529
    Abstract: O-2,6-Diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1.fwdarw.4)-O-?. beta.-D-xylofuranosyl-(1.fwdarw.5)!-N.sup.1 -?(S)-4-amino-2-hydroxy-1-oxobutyl!-2-deoxystreptamine, also known as 3'-deoxybutirosin A and acid addition salts of said compound. These compounds exhibit a wide spectrum of antibacterial activity.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: March 20, 1979
    Assignee: Parke, Davis & Company
    Inventors: Peter W. K. Woo, Theodore H. Haskell
  • Patent number: 4145347
    Abstract: N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a 2-oxo-1-pyrrolidineacetate ester with an appropriate amine.
    Type: Grant
    Filed: March 7, 1978
    Date of Patent: March 20, 1979
    Assignee: Parke, Davis & Company
    Inventors: Yvon J. L'Italien, Ivan C. Nordin
  • Patent number: 4144246
    Abstract: Lower alkyl 2-oxo-4-phenyl-1-pyrrolidineacetic acid esters which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting 4-phenyl-2-pyrrolidinone with a lower alkyl haloacetate in the presence of a strong base.
    Type: Grant
    Filed: November 15, 1976
    Date of Patent: March 13, 1979
    Assignee: Parke, Davis & Company
    Inventor: Yvon J. L'Italien
  • Patent number: 4138013
    Abstract: Pharmaceutical capsules with telescopically engaged body and cap portions, also known as hard shell capsules, having enteric properties. The capsule body and cap portions are formed by dip-molding using a homogeneous film-forming mixture comprising (1) hydroxypropyl methylcellulose and an ammonium salt of cellulose acetate phthalate polymer, or (2) gelatin and an ammonium salt of a copolymer of methacrylic acid and methacrylic acid alkyl ester; optionally with the inclusion of plasticizer and/or coloring agent. The capsules are soluble in or disintegrated by the alkaline intestinal secretions but are substantially insoluble or resistant to solution in the acid secretions of the stomach.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: February 6, 1979
    Assignee: Parke, Davis & Company
    Inventor: Yakutaro Okajima
  • Patent number: 4128540
    Abstract: A new decapeptide having the formula, pGlu-His-Trp-Ser-Tyr-Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2); salts thereof; production thereof by reacting pGlu-His-Trp-Ser-Tyr(N.sub.3) with Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), by reacting pGlu-His-Trp-Ser-Tyr-Gly(N.sub.3) with Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), or by reacting pGlu-His-Trp-Ser-Tyr-Gly-Leu(N.sub.3) with NO.sub.2 Arg-Pro-Gly(NH.sub.2); certain peptide intermediates and their salts used in the production thereof; and the use thereof in the preparation of luteinizing hormone releasing factor.
    Type: Grant
    Filed: May 25, 1972
    Date of Patent: December 5, 1978
    Assignee: Parke, Davis & Company
    Inventors: Mildred C. Rebstock, Ernest D. Nicolaides, Thomas F. Mick, Francis J. Tinney, Eugene L. Wittle
  • Patent number: 4112103
    Abstract: (+,-)-cis-.alpha.[3-(2,6-Dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2-py ridinemethanol and acid-addition salts. The compounds are pharmacological agents, especially antiarrhythmic agents. The compounds can be produced by reacting pyridyllithium with cis-.gamma.-(2,6-dimethylpiperidino)butyrophenone, or by reacting cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2- pyridinemethanol and acid-addition salts thereof and methods for treating cardiac arrhythmia using said pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: September 5, 1978
    Assignee: Parke, Davis & Company
    Inventor: Robert Willerton Fleming
  • Patent number: 4111923
    Abstract: New octapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R.sub.2 -Leu-Arg-Pro-R.sub.3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R.sub.2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro, D-Me.sub.5 Phe or D-Asn and R.sub.3 is NH.sub.2, NH(lower alkyl), N-(lower alkyl).sub.2, NH-benzyl, NHCH.sub.2 CH.sub.2 N-(lower alkyl).sub.2 or NH-CH.sub.2 CH.sub.2 SO.sub.2 NH-benzyl; methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said octapeptides as luteinizing hormone releasing factor antagonists.
    Type: Grant
    Filed: December 27, 1976
    Date of Patent: September 5, 1978
    Assignee: Parke, Davis & Company
    Inventors: Eugene Leroy Wittle, Mildred Catherine Rebstock, Ernest D. Nicolaides, Alfred Campbell
  • Patent number: 4105851
    Abstract: 4-Aryl-1,6-dihydro-1,3,8-trimethylimidazo[1,2-a]-pyrazolo[4,3-f][1,4]diazep ines; and acid-addition salts. The aryl group is o-fluorophenyl or o-chlorophenyl. The compounds are pharmacological agents, especially anticonvulsant and antianxiety agents. They can be produced by reacting an aryl-(2-hydroxymethyl)-imidazol-1-yl-1,3-dimethylpyrazol-4-ylmethanone hydrocarbon sulfonate ester with ammonia in the presence of iodide.
    Type: Grant
    Filed: June 17, 1976
    Date of Patent: August 8, 1978
    Assignee: Parke, Davis & Company
    Inventor: Horace A. De Wald
  • Patent number: 4101537
    Abstract: New octapeptides having the formula X-R.sup.1 -Trp-Ser(benzyl)-Tyr(benzyl)-R.sup.2 -Leu-Arg(R)-Pro-R.sup.3 -Y wherein X is a protective group, R is hydrogen or a protective group, R.sup.1 is a single bond, Gln, D-Leu or D-Val, R.sup.2 is D-Phe or D-Ala, R.sup.3 is a single bond or Gly and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: July 18, 1978
    Assignee: Parke, Davis & Company
    Inventors: Ernest D. Nicolaides, Francis John Tinney
  • Patent number: 4087416
    Abstract: New heptapeptides having the formula X-R-His(benzyl)-His(benzyl)--R.sup.1 --R.sup.2 --Trp--Ala--Y wherein X is a protective group, R is Pro or Gln; R.sup.1 and R.sup.2 are Ser(benzyl) or Tyr(benzyl) and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)-amino.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides
  • Patent number: 4087418
    Abstract: New hexapeptides having the formula X-Ser(benzyl)-Tyr(benzyl)-Ala-Leu-Arg-Pro-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventor: Eugene Leroy Wittle
  • Patent number: 4087417
    Abstract: New hexapeptides having the formula X-Trp-His-(benzyl)-Ser(benzyl)-Tyr(benzyl)-Pro-Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney