Abstract: Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system.
Type:
Application
Filed:
September 21, 2007
Publication date:
October 9, 2008
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSERM, PEPTIDE IMMUNE LIGANDS
Abstract: Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system.
Type:
Grant
Filed:
June 2, 2004
Date of Patent:
October 30, 2007
Assignees:
Peptide Immune Ligands, Institut National de la Sante et de la Recherche Medicale INSERM
Abstract: Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system.
Type:
Application
Filed:
June 2, 2004
Publication date:
February 10, 2005
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSERM, PEPTIDE IMMUNE LIGANDS
Abstract: Polyepitopic fragments of the E6 or E7 protein of HPV comprise a peptide sequence of about 15 to 30 amino acids. This peptide sequence contains amino acid sequences of at least 3 different epitopes binding stably to HLA molecules of identical or different type, when these epitopes are obtained by enzymatic degradation of the peptide sequence, particularly in the proteasome, such that at least 4 HLA molecules of different types bind to these epitopes. These 4 HLA molecules are selected from among those of types A1, A2, A3, A11, A24, A29, B7, B8, B18, B27, B35, B44, B51 and B62.
Type:
Grant
Filed:
April 29, 2002
Date of Patent:
August 31, 2004
Assignees:
Peptide Immune Ligands, Institut National de la Sante et de la Recherche Medicale
(INSERM)