Patents Assigned to Perio Products Ltd.
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Patent number: 6231888Abstract: A composition and method for the treatment of polyp and colon cancer is described, such composition and method providing for the colonic delivery and/or preferential metabolism of a drug or desired agent, especially an NSAID, in the colon of the patient in need such treatment.Type: GrantFiled: November 12, 1998Date of Patent: May 15, 2001Assignee: Perio Products Ltd.Inventors: E. Itzhak Lerner, Moshe Flashner, Adel Penhasi
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Patent number: 6197331Abstract: The invention is directed to a controlled-release solid composition for the oral cavity or “pharmaceutical oral patch” that adheres to hard dental surfaces, such as teeth and dentures, and releases an active pharmaceutical agent into the oral cavity. Release of the agent is for a predetermined period of time and at a predetermined sustained concentration. The site of action of the agent is local or systemic.Type: GrantFiled: July 24, 1997Date of Patent: March 6, 2001Assignee: Perio Products Ltd.Inventors: E. Itzhak Lerner, Vered Rosenberger, Moshe Flashner
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Patent number: 5866619Abstract: A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer. According to the invention, the matrix is resistant to chemical and enzymatic degradation in the stomach and small intestine. The matrix is degraded in the colon by bacterial enzymatic action, and the drug is released. The system is useful for targeting drugs to the colon in order to treat colonic disease. The system is also useful for enteric administration of drugs such as proteins and peptides which are otherwise degraded in the stomach and small intestine.Type: GrantFiled: November 26, 1997Date of Patent: February 2, 1999Assignees: Perio Products Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Amnon Sintov, Abraham Rubinstein
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Patent number: 5849266Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: April 4, 1995Date of Patent: December 15, 1998Assignee: Perio Products Ltd.Inventor: Michael Friedman
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Patent number: 5840332Abstract: A gastrointestinal delivery system is provided. The system comprises a drug in combination with a core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. These channels allow the release of drug from the core into the gastrointestinal tract. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time- dependent manner.Type: GrantFiled: January 18, 1996Date of Patent: November 24, 1998Assignee: Perio Products Ltd.Inventors: E. Itzhak Lerner, Moshe Flashner, Adel Penhasi
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Patent number: 5648399Abstract: The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: April 25, 1995Date of Patent: July 15, 1997Assignees: Perio Products, Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Michael Friedman, Amnon Sintov
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Patent number: 5639795Abstract: The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: April 25, 1995Date of Patent: June 17, 1997Assignees: Perio Products, Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Michael Friedman, Amon Sintov
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Patent number: 5525634Abstract: A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer. According to the invention, the matrix is resistant to chemical and enzymatic degradation in the stomach and small intestine. The matrix is degraded in the colon by bacterial enzymatic action, and the drug is released. The system is useful for targeting drugs to the colon in order to treat colonic disease. The system is also useful for enteric administration of drugs such as proteins and peptides which are otherwise degraded in the stomach and small intestine.Type: GrantFiled: February 10, 1994Date of Patent: June 11, 1996Assignees: Perio Products, Ltd., Yissum Research Development Co. of the Hebrew Univ. of JerusalemInventors: Amnon Sintov, Abraham Rubinstein
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Patent number: 5438076Abstract: The invention relates methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: January 4, 1993Date of Patent: August 1, 1995Assignee: Perio Products, Ltd.Inventors: Michael Friedman, Amnon Sintov
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Patent number: 5160737Abstract: The invention relates to a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: March 28, 1990Date of Patent: November 3, 1992Assignees: Perio Products Ltd., Yissum Research Development CompanyInventors: Michael Friedman, Amnon Sintov