Patents Assigned to Pharmacia Italia S.p.A.
  • Publication number: 20030109514
    Abstract: The present invention relates to novel stable solution formulations comprising oxaliplatin alone or in combination with irinotecan (CPT-11), an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.
    Type: Application
    Filed: August 22, 2002
    Publication date: June 12, 2003
    Applicant: Pharmacia Italia, S.p.A.
    Inventors: Sara Lauria, Alessandro Martini, Cristina Ciocca
  • Patent number: 6576612
    Abstract: The present invention relates to an administration schedule comprising the intravenous administration of a &agr;-halogen-acryloyl distamycin derivative of formula (I) wherein R is a bromine or chlorine atom; or a pharmaceutically acceptable salt thereof. The above administration allows the treatment of a variety of tumors in mammals.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: June 10, 2003
    Assignees: Pharmacia Italia S.p.A., Pharmacia & Upjohn Company
    Inventors: Camilla Fowst, Franzanne Vreeland, Maria Cristina Rosa Geroni
  • Patent number: 6569452
    Abstract: An oral pharmaceutical formulation, which comprises, in a hydroxypropylmethylcellulose capsule, a camptothecin analogue dispersed or solubilized in a semi-solid matrix of a polyethyleneglycol with a molecular weight ranging from 400 to 20000.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: May 27, 2003
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Paola Civaroli, Lorena Muggetti, Alessandro Martini
  • Patent number: 6537990
    Abstract: The present invention relates to combined preparations comprising a morpholinyl anthracycline administered in combination anticancer agents chosen from an alkylating agent, an antimetabolite, a topoisomerase II inhibitor, a topoisomerase I inhibitor, an antimitotic drug and a platinum derivative, which are useful anticancer therapy, particularly in the treatment of a primary or metastatic liver cancer.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 25, 2003
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Maria Cristina Geroni, Marina Ripamonti, Michele Caruso, Antonino Suarato
  • Patent number: 6486322
    Abstract: Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I): wherein R is a hydrogen or halogen atom or a group selected from —CN, —OH, —OCOR4, —(CH2)nNH2, —(CH2)nNHR4, —(CH2)nNHCOR4, —(CH2)nNHCONR4R5, —(CH2)nNHCOOR4, or —(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R2 is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from —CONR4R5, —COOR4, —CONHOR4, —SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed. These compounds are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: November 26, 2002
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Antonio Longo, Maria Gabriella Brasca, Paolo Orsini, Gabriella Traquandi, Valeria PittalĂ , Anna Vulpetti, Mario Varasi, Paolo Pevarello
  • Patent number: 6482920
    Abstract: The present invention relates to acrylol substituted distamycin derivatives, to pharmaceutical compositions comprising such derivatives as well as their use in methods of treating humans and animals, particularly as anti-tumor agents.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: November 19, 2002
    Assignee: Pharmacia Italia, S.p.A.
    Inventors: Paolo Cozzi, Italo Beria, Giovanni Biasoli, Marina Caldarelli, Laura Capolongo, Cristina Franzetti
  • Patent number: 6476068
    Abstract: The present invention relates to novel stable solution formulations comprising oxaliplatin, an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: November 5, 2002
    Assignee: Pharmacia Italia, S.p.A.
    Inventors: Sara Lauria, Alessandro Martini, Cristina Ciocca
  • Patent number: 6455290
    Abstract: The present invention provides a human polypeptide homolog of human tankyrase protein (THP) and polynucleotides which identify and encode THP. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of THP agonists/antagonists, useful for the treatment of human diseases, such as human cancer and age related diseases.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: September 24, 2002
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Jens Berthelsen, Salvatore Toma, Antonella Isacchi
  • Patent number: 6455559
    Abstract: Compounds represented by formula (I) wherein R is a C3-C5 cycloalkyl group, R1 is a hydrogen atom or a methyl group, or a pharmaceutically acceptable salt thereof; are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 24, 2002
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Paolo Pevarello, Paolo Orsini, Gabriella Traquandi, Maria Gabriella Brasca, Raffaella Amici, Manuela Villa, Claudia Piutti, Mario Varasi, Antonio Longo