Patents Assigned to Pharmacia & Upjohn AB
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Patent number: 7193056Abstract: The present invention relates to a process for purifying a hydrophobic or amphiphilic compound, by first mixing a starting material containing the hydrophobic or amphiphilic compound with a first polymeric material, water and at least one of a second polymeric material and a surfactant, wherein the first polymeric material and the second polymeric material and/or surfactant are immiscible in the resulting primary aqueous solution. The process further comprises maintaining the primary aqueous solution for a period of time sufficient for essentially separating the phases formed, and then removing the phase containing the main portion of the hydrophobic or amphiphilic compound and the second polymeric material and/or surfactant. The second polymeric material and/or surfactant are separated from the hydrophobic or amphiphilic compound, and subsequently recycled to the initial mixing step.Type: GrantFiled: June 8, 2004Date of Patent: March 20, 2007Assignee: Pharmacia & UpJohn ABInventors: Hans Ageland, Lena Nyström, Josefine Persson, Folke Tjerneld
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Publication number: 20040141978Abstract: The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in screening methods, wherein novel substances are created exhibiting the same advantageous anti-angiogenic properties as angiostatin.Type: ApplicationFiled: November 25, 2003Publication date: July 22, 2004Applicant: PHARMACIA & UPJOHN ABInventors: Lars Holmgren, Boris Troyanovsky
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Patent number: 6436654Abstract: The present invention relates to a method for identifying compounds capable of modulating the function of a functional domain of human HIF-1&agr;, said method comprising (i) contacting a candidate compound with a variant of human HIF-1&agr;, said variant essentially lacking at least one functional domain of human HIF-1&agr;, or having a mutation making at least one functional domain of human HIF-1&agr; essentially inactive, said functional domain or domains being selected from the group consisting of (a) the PAS-B domain located in human HIF-1&agr; between amino acids 178 and 390, (b) the C-terminal nuclear localization sequence (NLS) located in human HIF-1&agr; essentially at amino acids 718 to 721, and (c) the transactivator/coactivator domain (N-TAD) located in human HIF-1&agr; essentially between amino acids 531 to 584, and (d) the transactivator/coactivator domain (C-TAD) located in human HIF-1&agr; essentially between amino acids 813 and 826, and (ii) determining the effect of the candidate compouType: GrantFiled: November 12, 1999Date of Patent: August 20, 2002Assignee: Pharmacia & Upjohn ABInventors: Anders Berkenstam, Lorenz Poellinger
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Patent number: 6361561Abstract: Polysiloxanes suitable for the preparation of intraocular lenses by a crosslinking reaction, having a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens and a viscosity suitable for injection through a standard cannula are provided. Moreover, injectable intraocular lens material based on these polysiloxanes and methods of preparing intraocular lenses by direct injection into the capsular bag of the eye are also disclosed.Type: GrantFiled: October 13, 1999Date of Patent: March 26, 2002Assignee: Pharmacia & Upjohn ABInventors: Peter P. Huo, Stephen Q. Zhou, Christine J. Y. Liau, Sverker Norrby
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Publication number: 20020009523Abstract: Method for marking an object where the object is placed in a package whereby a pattern in said package is caused to make a marking in said object. Objects being marked with the above method. The invention is especially useful for marking solid or semi-solid formulations of drugs, candy and food-stuff. Specifically the invention is useful to mark nicotine-containing chewing gums. Other solid or semi-solid objects can equally well be marked using the present invention.Type: ApplicationFiled: October 1, 2001Publication date: January 24, 2002Applicant: Pharmacia & Upjohn ABInventor: Stig Gustaesson
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Patent number: 6335030Abstract: The present invention is drawn to a device for the transdermal administration of dextromethorphan, (+)-3-methoxy-17-methyl-9a,13a,14a-morphanin, and salts, prodrugs and metabolites thereof, together with a pharmaceutically acceptable carrier, to a human being or animal in need thereof, to achieve an antitussive effect. The present invention is further drawn to a method of achieving an antitussive effect in a human being or animal which comprises transdermally administering dextromethorphan, (+)-3-methoxy-17-methyl-9a,13a,14a-morphanin, and salts, prodrugs and metabolites thereof, together with a pharmaceutically acceptable carrier.Type: GrantFiled: October 23, 1998Date of Patent: January 1, 2002Assignee: Pharmacia & Upjohn ABInventors: Ulla Hoeck, Bo Kreilgaard, Helle Kristensen
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Patent number: 6329184Abstract: A crystalline form of mammalian TRAP (tartrate-resistant and purple acid phosphatase) is described. The enzyme is activated by cleavage prior to crystallization with a protease and the crystalline form of the mammalian TRAP is capable of being used for X-ray studies.Type: GrantFiled: December 1, 1999Date of Patent: December 11, 2001Assignee: Pharmacia & Upjohn ABInventor: Jonas Uppenberg
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Patent number: 6221858Abstract: Use of a compound of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 is either halogen or hydrogen and R2 is halogen; X is CH2, O or S; R3 and R4 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3; A is selected from the pyrimidyl- or pyridyl-groups (a), (b) or (c) wherein R5, R6 and R7 are as defined in the description; for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse or for treatment thereof.Type: GrantFiled: November 5, 1998Date of Patent: April 24, 2001Assignee: Pharmacia & Upjohn ABInventor: Anders Björk
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Patent number: 6197299Abstract: A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.Type: GrantFiled: September 16, 1998Date of Patent: March 6, 2001Assignee: Pharmacia & Upjohn ABInventors: Mikael Dohlsten, Eva Åkerblom, Peter A. Lando, Terje Kalland, Gunnar Hedlund
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Patent number: 6171276Abstract: A delivery device including a) a housing, b) a container for a fluid arranged in the housing, the container having an opening, c) a delivery conduit connected in fluid communication with the opening, the conduit having a front end in flow respect distal from the container and a rear end in flow respect proximal to the container, the front end and the rear end defining an axis therebetween and a forward direction and a rearward direction, and d) a pump arranged to deliver fluid at least in a direction from the container through the conduit, the device comprising, a sensor able to change state in at least one respect in response to a predetermined proximity of an object to the sensor in a sensing direction, a converter, separate from or integral with the sensor, converting at least one of the sensor states into an electromagnetic signal, and a processor, receiving the electromagnetic signal and delivering a control signal to an operational component of the device.Type: GrantFiled: August 5, 1998Date of Patent: January 9, 2001Assignee: Pharmacia & Upjohn ABInventors: Barbara Lippe, Anders Holte, Hans Himbert, Birger Hjertman, Bohdan Pavlu, Magnus Westermark, Rainer Bosse, Markus Adam
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Patent number: 6152897Abstract: The invention relates to a one-dose syringe comprising a first chamber with a freeze-dried composition comprising a protein in an amount of less than 1.4 mg, amino acid and stabilizer where the weight ratio between protein and amino acid versus stabilizer is less than 1.5 and in which the ratio of the weight of the dry component versus the cake volume in the first chamber is above 12 mg/ml, and a second chamber with an aqueous reconstitution solution with an injectable volume of less than 0.5 ml.Type: GrantFiled: November 20, 1998Date of Patent: November 28, 2000Assignee: Pharmacia & Upjohn ABInventors: Karin Limrell, Ebba Florin-Robertsson, Elvy Hokby, Ulf Nilsson, Anders Strom
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Patent number: 6134920Abstract: Methods of plastically forming an axially extended zone of the interior surface of a hollow glass tube heated to its forming temperature employ a generally cylindrical embossing mandrel connected to a driving shaft. The hollow glass tube and the embossing mandrel are brought together at a predetermined start position for the embossing mandrel inside the glass tube and are brought into contact in an area in which the zone is to be formed on the interior surface of the glass tube. A relative rolling off planetary motion between the embossing mandrel and the glass tube is provided while plastically forming the zone of the glass tube and creating depressions therein.Type: GrantFiled: March 9, 1998Date of Patent: October 24, 2000Assignee: Pharmacia & Upjohn ABInventors: Birger Hjertman, Wolfgang Heidl
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Patent number: 6129936Abstract: Method for marking an object where the object is placed in a package whereby a pattern in said package is caused to make a marking in said object. Objects being marked with the above method. The invention is especially useful for marking solid or semi-solid formulations of drugs, candy and food-stuff. Specifically the invention is useful to mark nicotine-containing chewing gums. Other solid or semi-solid objects can equally well be marked using the present invention.Type: GrantFiled: May 11, 1998Date of Patent: October 10, 2000Assignee: Pharmacia & Upjohn ABInventor: Stig Gustafsson
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Patent number: 6124354Abstract: This invention relates to the use of 2-(diisopropylamino)-ethyl-1-phenyl-cyclopentane-carboxylate or 2-(diisopropylamino)-ethyl-1-phenyl-cyclohexane-carboxylate, or a pharmaceutically accceptable salt thereof, for treatment of urinary incontinence or irritable bowel syndrome (IBS).Type: GrantFiled: April 12, 1999Date of Patent: September 26, 2000Assignee: Pharmacia & Upjohn ABInventors: Eva .ANG.kerblom, Martin Haraldsson, Rolf Johansson, Katarina Beierlein, Birger Sjoberg, Erik Ringberg, Birgitta Weinz
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Patent number: D441447Type: GrantFiled: May 30, 2000Date of Patent: May 1, 2001Assignee: Pharmacia & Upjohn ABInventors: Birger Hjertman, Jonas Fridholm, Carl-Göran Crafoord, Maria Benktzon, Hans Himbert
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Patent number: D451202Type: GrantFiled: September 3, 1999Date of Patent: November 27, 2001Assignee: Pharmacia & Upjohn ABInventor: Jimmie Ward
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Patent number: D430015Type: GrantFiled: December 11, 1998Date of Patent: August 29, 2000Assignee: Pharmacia & Upjohn ABInventors: Hans Himbert, Carl-Goran Crafoord
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Patent number: D430666Type: GrantFiled: January 19, 2000Date of Patent: September 5, 2000Assignee: Pharmacia & Upjohn ABInventors: Rudolf Cseke, Birger Hjertman, Bohdan Pavlu, Gunnar Pettersson, Magnus Westermark, Daniel Felder, Guido Hertig, Rainer Bosse
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Patent number: D432648Type: GrantFiled: September 18, 1998Date of Patent: October 24, 2000Assignee: Pharmacia & Upjohn ABInventor: Lena Stromblad
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Patent number: D434497Type: GrantFiled: September 5, 1997Date of Patent: November 28, 2000Assignee: Pharmacia & Upjohn ABInventors: Rudolf Cseke, Birger Hjertman, Bohdan Pavlu, Gunnar Pettersson, Magnus Westermark, Daniel Felder, Guido Hertig, Rainer Bosse