Patents Assigned to Phase Holographic Imaging PHI AB
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Patent number: 10730986Abstract: The present invention relates to a molecularly imprinted polymer for binding glycans, wherein the molecularly imprinted polymer is obtainable by providing a saccharide template such as a glycan; providing at least two functional monomers capable of cooperatively; interacting with the template; providing a crosslinking monomer; polymerizing the monomers optionally dissolved in a solvent, in presence of the saccharide template; and removing the template from the formed polymer. The invention is also related to a method for their production and use of the molecularly imprinted polymer.Type: GrantFiled: May 9, 2016Date of Patent: August 4, 2020Assignees: Phase Holographic Imaging PHI AB, Bundesrepublik Deutschland, vertreten durch den Bundesminister für Wirtschaft und EnergieInventors: Sudhirkumar Shinde, Anette Gjörloff Wingren, Knut Rurack, Börje Sellergren, Wei Wan
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Patent number: 9423342Abstract: A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude-and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.Type: GrantFiled: February 15, 2012Date of Patent: August 23, 2016Assignee: Phase Holographic Imaging PHI ABInventors: Peter Egelberg, Mikael Sebesta, Anders Isaksson
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Patent number: 8937756Abstract: The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained or labelled to at least one cell or conjugated to antibodies which are bound either directly to said at least one cell or indirectly via another or several antibodies in a chain bound to said at least one cell.Type: GrantFiled: February 7, 2011Date of Patent: January 20, 2015Assignee: Phase Holographic Imaging PHI ABInventors: Mikael Sebesta, Kersti Alm, Anders Långberg, Anna Mölder, Johan Persson, Lennart Gisselsson
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Publication number: 20140113323Abstract: A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude- and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.Type: ApplicationFiled: February 15, 2012Publication date: April 24, 2014Applicant: PHASE HOLOGRAPHIC IMAGING PHI ABInventors: Peter Egelberg, Mikael Sebesta, Anders Isaksson
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Publication number: 20130230864Abstract: The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained or labelled to at least one cell or conjugated to antibodies which are bound either directly to said at least one cell or indirectly via another or several antibodies in a chain bound to said at least one cell.Type: ApplicationFiled: February 7, 2011Publication date: September 5, 2013Applicant: Phase Holographic Imaging PHI ABInventors: Mikael Sebesta, Kersti Alm, Anders Långberg, Anna Molder, Johan Persson, Lennart Gisselsson
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Publication number: 20120196316Abstract: Method for analyzing a sample comprising at least one ovum or embryo, the method being based on digital holographic imaging, the method comprising the following steps: creating at least one object beam and at least one reference beam of light, where said at least one object beam and said at least one reference beam are mutually coherent; exposing said sample to said at least one object beam; superimposing said at least one object beam that has passed through said sample with said at least one reference beam and thereby creating an interference pattern; detecting said interference pattern, called hologram; reconstructing phase and/or amplitude information of object wavefront from said interference pattern; and constructing at least one ovum or embryo analysis image and determining at least one ovum or embryo quality showing parameter from said phase and/or amplitude information.Type: ApplicationFiled: June 24, 2010Publication date: August 2, 2012Applicant: PHASE HOLOGRAPHIC IMAGING PHI ABInventors: Mikael Sebesta, Johan Persson, Lennart Gisselsson, Anna Mölder, Anders Längberg
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Patent number: 7948632Abstract: A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.Type: GrantFiled: December 22, 2006Date of Patent: May 24, 2011Assignee: Phase Holographic Imaging PHI ABInventors: Mats Gustafsson, Mikael Sebesta
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Publication number: 20100060897Abstract: A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.Type: ApplicationFiled: December 22, 2006Publication date: March 11, 2010Applicant: Phase Holographic Imaging PHI ABInventor: Mats Gustafsson
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Publication number: 20070109555Abstract: A method and device for determining refractive index of an object compared to a refractive index of a surrounding medium. The object is exposed to a laser object beam and the scattered light interferes with a laser reference beam to obtain a hologram. The hologram is analyzed for phase information, and based thereon, it is determined if the refractive index of the object is higher or lower than the refractive index of the surrounding medium.Type: ApplicationFiled: October 7, 2004Publication date: May 17, 2007Applicant: PHASE HOLOGRAPHIC IMAGING PHI ABInventors: Mats Gustafsson, Mikael Sebesta, Peter Egelberg, Thomas Lenart, Sven-Goran Pettersson, Bengt Bengtsson