Patents Assigned to Phase Holographic Imaging PHI AB
  • Patent number: 9423342
    Abstract: A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude-and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: August 23, 2016
    Assignee: Phase Holographic Imaging PHI AB
    Inventors: Peter Egelberg, Mikael Sebesta, Anders Isaksson
  • Patent number: 8937756
    Abstract: The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained or labelled to at least one cell or conjugated to antibodies which are bound either directly to said at least one cell or indirectly via another or several antibodies in a chain bound to said at least one cell.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: January 20, 2015
    Assignee: Phase Holographic Imaging PHI AB
    Inventors: Mikael Sebesta, Kersti Alm, Anders Långberg, Anna Mölder, Johan Persson, Lennart Gisselsson
  • Publication number: 20140113323
    Abstract: A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude- and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.
    Type: Application
    Filed: February 15, 2012
    Publication date: April 24, 2014
    Applicant: PHASE HOLOGRAPHIC IMAGING PHI AB
    Inventors: Peter Egelberg, Mikael Sebesta, Anders Isaksson
  • Publication number: 20130230864
    Abstract: The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained or labelled to at least one cell or conjugated to antibodies which are bound either directly to said at least one cell or indirectly via another or several antibodies in a chain bound to said at least one cell.
    Type: Application
    Filed: February 7, 2011
    Publication date: September 5, 2013
    Applicant: Phase Holographic Imaging PHI AB
    Inventors: Mikael Sebesta, Kersti Alm, Anders Långberg, Anna Molder, Johan Persson, Lennart Gisselsson
  • Publication number: 20120196316
    Abstract: Method for analyzing a sample comprising at least one ovum or embryo, the method being based on digital holographic imaging, the method comprising the following steps: creating at least one object beam and at least one reference beam of light, where said at least one object beam and said at least one reference beam are mutually coherent; exposing said sample to said at least one object beam; superimposing said at least one object beam that has passed through said sample with said at least one reference beam and thereby creating an interference pattern; detecting said interference pattern, called hologram; reconstructing phase and/or amplitude information of object wavefront from said interference pattern; and constructing at least one ovum or embryo analysis image and determining at least one ovum or embryo quality showing parameter from said phase and/or amplitude information.
    Type: Application
    Filed: June 24, 2010
    Publication date: August 2, 2012
    Applicant: PHASE HOLOGRAPHIC IMAGING PHI AB
    Inventors: Mikael Sebesta, Johan Persson, Lennart Gisselsson, Anna Mölder, Anders Längberg
  • Patent number: 7948632
    Abstract: A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: May 24, 2011
    Assignee: Phase Holographic Imaging PHI AB
    Inventors: Mats Gustafsson, Mikael Sebesta
  • Publication number: 20100060897
    Abstract: A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.
    Type: Application
    Filed: December 22, 2006
    Publication date: March 11, 2010
    Applicant: Phase Holographic Imaging PHI AB
    Inventor: Mats Gustafsson
  • Publication number: 20070109555
    Abstract: A method and device for determining refractive index of an object compared to a refractive index of a surrounding medium. The object is exposed to a laser object beam and the scattered light interferes with a laser reference beam to obtain a hologram. The hologram is analyzed for phase information, and based thereon, it is determined if the refractive index of the object is higher or lower than the refractive index of the surrounding medium.
    Type: Application
    Filed: October 7, 2004
    Publication date: May 17, 2007
    Applicant: PHASE HOLOGRAPHIC IMAGING PHI AB
    Inventors: Mats Gustafsson, Mikael Sebesta, Peter Egelberg, Thomas Lenart, Sven-Goran Pettersson, Bengt Bengtsson