Patents Assigned to Philipps-Universitat Marburg
  • Patent number: 10269562
    Abstract: The invention provides the use of at least one binary group 15 element compound of the general formula R1R2E-E?R3R4 (I) or R5E(E?R6R7)2 (II) as the educt in a vapor deposition process. In this case, R1, R2, R3 and R4 are independently selected from the group consisting of H, an alkyl radical (C1-C10) and an aryl group, and E and E? are independently selected from the group consisting of N, P, As, Sb and Bi. This use excludes hydrazine and its derivatives. The binary group 15 element compounds according to the invention allow the realization of a reproducible production and/or deposition of multinary, homogeneous and ultrapure 13/15 semiconductors of a defined combination at relatively low process temperatures. This makes it possible to completely waive the use of an organically substituted nitrogen compound such as 1.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: April 23, 2019
    Assignee: PHILIPPS-UNIVERSITÄT MARBURG
    Inventors: Carsten Von Haenisch, Kerstin Volz, Wolfgang Stolz, Eduard Sterzer, Andreas Beyer, Dominik Keiper, Benjamin Ringler
  • Publication number: 20170243740
    Abstract: The invention provides the use of at least one binary group 15 element compound of the general formula R1R2E-E?R3R4 (I) or R5E(E?R6R7)2 (II) as the educt in a vapor deposition process. In this case, R1, R2, R3 and R4 are independently selected from the group consisting of H, an alkyl radical (C1-C10) and an aryl group, and E and E? are independently selected from the group consisting of N, P, As, Sb and Bi. This use excludes hydrazine and its derivatives. The binary group 15 element compounds according to the invention allow the realization of a reproducible production and/or deposition of multinary, homogeneous and ultrapure 13/15 semiconductors of a defined combination at relatively low process temperatures. This makes it possible to completely waive the use of an organically substituted nitrogen compound such as 1.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 24, 2017
    Applicant: Philipps-Universität Marburg
    Inventors: Carsten VON HAENISCH, Kerstin VOLZ, Wolfgang STOLZ, Eduard STERZER, Andreas BEYER, Dominik KEIPER, Benjamin RINGLER
  • Publication number: 20150018411
    Abstract: The present invention concerns substances which act as selective ligands of nuclear receptors of the PPAR beta/delta subtype and which can be used for the treatment of PPAR beta/delta-mediated diseases. The substances of this invention act as inhibitors of PPAR beta/delta receptors.
    Type: Application
    Filed: June 6, 2012
    Publication date: January 15, 2015
    Applicant: PHILIPPS-UNIVERSITAT MARBURG
    Inventors: Wibke Diederich, Stefanie Dorr, Kerstin Kaddatz, Gerhard Klebe, Rolf Muller, Simone Naruhn, Veronika Pape, Josefine Stockert, Philipp Manuel Toth
  • Patent number: 8871881
    Abstract: The invention at hand concerns hydrophobic polymer surfaces, in particular superhydrophobic polymer surfaces, comprising at least one homo- or copolymer, which comprises at least one side chain with at least one fluoro-substituted aryl group. Furthermore, the invention at hand concerns a method for the production of polymer surfaces of this type, their use and polymers of the general formula I: wherein n is an integer between 10 and 4,500, preferably between 20 and 2,200 and particularly preferably between 100 and 670.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: October 28, 2014
    Assignee: Philipps-Universität Marburg
    Inventors: Andreas Greiner, Seema Agarwal, Michael Bognitzki, Sven Horst
  • Patent number: 8865865
    Abstract: The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases, caused by bacterial pathogens or viruses, as well as for therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the onset of obesity, as well as the use of these compounds as inhibitors of the proprotein convertases which cleave behind basic P1 residues, especially for inhibition of the protease furin.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 21, 2014
    Assignee: Philipps-Universitat Marburg
    Inventors: Torsten Steinmetzer, Gero Becker, Wolfgang Garten
  • Publication number: 20140213781
    Abstract: The invention relates to peptide mimetics comprising the residues P4-P3-P2-P1, which were cyclized between the side chains of P3 and P2 amino acid and are, as inhibitors of the serine protease plasmin, suitable to be used to inhibit fibrinolysis and thus to reduce blood loss in hyperfibrinolytic conditions, for example during surgery.
    Type: Application
    Filed: July 9, 2012
    Publication date: July 31, 2014
    Applicant: PHILIPPS-UNIVERSITÄT MARBURG
    Inventors: Torsten Steinmetzer, Sebastian Saupe
  • Publication number: 20130095037
    Abstract: In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-1 receptor and can be used, labeled or unlabeled, for the production of an agent for diagnostic and therapy of benign and malignant diseases, in which GLP-1 receptor expression plays a role.
    Type: Application
    Filed: August 24, 2012
    Publication date: April 18, 2013
    Applicant: Philipps-Universitat Marburg
    Inventors: Martin GOTTHARDT, Martin Béhé, Thomas Behr, Burkhard J. Göke
  • Publication number: 20120270942
    Abstract: Disclosed herein is a device for the application of agricultural active agents, wherein the device is suitable to be brought to the site of action in a manner temporally and spatially separated from the production process, and comprises a dispenser and non-water-soluble nanofibers and/or mesofibers charged with agricultural active agents. The polymers from which the nanofibers and/or mesofibers are made are preferably biodegradable. The agricultural active agents are selected from fungicides, herbicides, batericides, plant growth regulators and plant nutrients. These are preferably pheromones, kairomones and signaling substances. Furthermore, a method for the production of this device is disclosed, wherein the nanofibers and/or mesofibers charged with active agents are produced via electrospinning. The device is suitable to be used to bring agricultural active agents to the site of action in a manner temporally and spatially separated from the production of this device.
    Type: Application
    Filed: October 21, 2010
    Publication date: October 25, 2012
    Applicants: Justus-Liebig-Universitat Giessen, Baden-Wurttemberg Versuchs- und Forschungsanstalt fur Weinbau und Weinbehandlung, Philipps-Universitat Marburg
    Inventors: Andreas Greiner, Joachim H. Wendorff, Seema Agarwall, Christoph Hellmann, Michael Breuer, Günter Leithold, Hans E. Hummel, Detlef Hein
  • Patent number: 8268781
    Abstract: In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-receptor and can be used, labeled or unlabeled, for the production of an agent for diagnostic and therapy of benign and malignant diseases, in which GLP-1 receptor expression plays a role.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: September 18, 2012
    Assignee: Philipps-Universitat Marburg
    Inventors: Martin Gotthardt, Martin Béhé, Thomas Behr, Burkhard J. Göke
  • Patent number: 8206442
    Abstract: The invention concerns an intraocular lens device which is used in particular for treatment of diseases of the central retina (macula) with retinal areas which are still healthy. The main principle of the invention at hand is that a lens device is provided for the redirection of the focal point from an area with impaired retinal function to a functioning area which comprises at least one convex lens element and several wedge-shaped recesses. Surprisingly it was found that a considerable reduction of the thickness of the lens device is thus achievable when several wedge-shaped recesses are provided.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: June 26, 2012
    Assignee: Philipps-Universität Marburg
    Inventors: Saadettin Sel, Jörg Heber
  • Publication number: 20120107900
    Abstract: The present invention provides electrospun polymer fibers comprising bacteria-containing hydrogel particles. Bacteria-containing hydrogel particles are produced by crosslinking water-soluble polymers to form hydrogels and mixing them with a bacteria suspension. The crosslinking is suitable to be carried out either chemically before the addition of the bacteria suspension or physically before or after this addition. Subsequently, these hydrogel particles are electrospun together with an electrospinnable polymer solution to form fibers or fibre non-wovens. The bacteria which are located in these hydrogel particles or in the electrospun polymer fibers comprising these particles, respectively, are capable of surviving for a long period (several months) without the supply of water or cell-culture media and are simultaneously protected against the effect of solvents, for example alcohols, acetone, chlorinated hydrocarbons, ethers and toluene, which would otherwise kill said bacteria.
    Type: Application
    Filed: December 18, 2009
    Publication date: May 3, 2012
    Applicant: Philipps-Universitat Marburg
    Inventors: Andreas Greiner, Seema Agarwal, Marco Gensheimer
  • Publication number: 20120083037
    Abstract: The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein the non-viral transfection agent is advantageously produced by means of electrospinning. The cationic polymer is favorably a polyimine or polyethyleneimine and can be modified with one or more hydrophilic polymers coupled thereto. It can also be advantageous to couple the cationic polymer with one or more carbohydrates and/or with a receptor-specific ligand. The nucleic acid is a DNA or an RNA, or a DNA or RNA derivative, advantageously a therapeutically active nucleic acid. The nanofibers are composed of biodegradable, biocompatible polymers. The nanofibers or the entire transfection agent can be provided with a polymer coating.
    Type: Application
    Filed: January 29, 2010
    Publication date: April 5, 2012
    Applicant: Philipps Universitat Marburg
    Inventors: Joachim H. Wendorff, Achim Aigner, Ronald Dersch, Sabrina Höbel, Markus Rudisile
  • Publication number: 20110312873
    Abstract: The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases, caused by bacterial pathogens or viruses, as well as for therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the onset of obesity, as well as the use of these compounds as inhibitors of the proprotein convertases which cleave behind basic P1 residues, especially for inhibition of the protease furin.
    Type: Application
    Filed: October 29, 2009
    Publication date: December 22, 2011
    Applicant: PHILIPPS-UNIVERSITAT MARBURG
    Inventors: Torsten Steinmetzer, Gero Becker, Wolfgang Garten
  • Publication number: 20110300251
    Abstract: Carriers for the production and targeted and/or delayed release, particularly of agricultural active substances, as well as a method for the output and a device for the production of such carriers in a loaded or unloaded state are proposed. The method and the device use the technology of electrospinning.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 8, 2011
    Applicants: Justus-Liebig Universitat Giessen, Philipps-Universitat Marburg
    Inventors: Andreas GREINER, Hans E. Hummel, Joachim H. Wendorff, Mathias Becker, Roland Dersch
  • Publication number: 20110300383
    Abstract: The invention relates to supports consisting of nanoscalar polymer fibres, polymer tubes or hollow fibres for the application and targeted and/or delayed release of ingredients, in particular, agricultural active ingredients. The invention also relates to a method and a device for the production of supports of this type in a charged or empty state. The method and device use electrospinning technology.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 8, 2011
    Applicants: Justus-Liebig Universitat Giessen, Philipps-Universitat Marburg
    Inventors: Andreas GREINER, Hans E. Hummel, Joachim H. Wendorff, Mathias Becker, Roland Dersch
  • Publication number: 20110293846
    Abstract: The invention relates to supports consisting of nanoscalar polymer fibres, polymer tubes or hollow fibres for the application and targeted and/or delayed release of ingredients, in particular, agricultural active ingredients. The invention also relates to a method and a device for the production of supports of this type in a charged or empty state. The method and device use electrospinning technology.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 1, 2011
    Applicants: Justus-Liebig Universitat Giessen, Philipps-Universitat Marburg
    Inventors: Andreas GREINER, Hans E. Hummel, Joachim H. Wendorff, Mathias Becker, Roland Dersch
  • Patent number: 8017061
    Abstract: The invention relates to supports consisting of nanoscalar polymer fibres, polymer tubes or hollow fibres for the application and targeted and/or delayed release of ingredients, in particular, agricultural active ingredients. The invention also relates to a method and a device for the production of supports of this type in a charged or empty state. The method and device use electrospinning technology.
    Type: Grant
    Filed: May 30, 2005
    Date of Patent: September 13, 2011
    Assignees: Philipps-Universitat Marburg, Justus-Liebig Universitat Giessen
    Inventors: Andreas Greiner, Hans E. Hummel, Joachim H. Wendorff, Mathias Becker, Roland Dersch
  • Patent number: 7981354
    Abstract: The invention relates to a method for producing metal oxide fibers with diameters on the micro- and nanometric scale by using electrospinning. At least one polymer is dissolved in a solvent, a metal salt is dissolved in this polymer solution, and this mixture is subsequently electrospun into fibers. Breaking down the polymer renders metal oxide fibers accessible that can be optionally reduced into the corresponding metal fibers.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: July 19, 2011
    Assignee: Philipps-Universitat Marburg
    Inventors: Joachim H. Wendorff, Andreas Greiner, Michael Bognitzki, Martin Graeser
  • Publication number: 20110160426
    Abstract: The invention at hand provides hydrolytically degradable ionic copolymers. These ionic copolymerizates are composed of one cyclic ketene acetal A, one anionic or cationic methacrylic acid derivative B, selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylene-allyloxy)]ethanesulfonate, [2-(2-methyl-1-methylene-allyloxy)ethyl]phosphonate or a quaternary amine of the N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and, optionally, a neutral methacrylic acid derivative C. The hydrolytically degradable anionic copolymers according to the present invention are produced by polymerizing the components A, B and C in the presence of a radical initiator under inert gas atmosphere and subsequent purification. All copolymers according to the present invention are hydrolytically degradable. Copolymers comprising a maximum of 40 mol-% of ester groups in the backbone are additionally biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% of quaternized DMAEMA is allowed to be available.
    Type: Application
    Filed: April 9, 2009
    Publication date: June 30, 2011
    Applicant: PHILIPPS-UNIVERSITAT MARBURG
    Inventors: Andreas Greiner, Seema Agarwal, Thomas Kissel, Liqun Ren
  • Patent number: 7915016
    Abstract: The present invention provides a new procedure for the synthesis of cDNA from single cells after microdissection. It has the advantage that it is cost-efficient and can be carried out quickly with only few steps, even by less skilled laboratory employees. For the first time, the time-consuming and risky step of RNA isolation is omitted during cDNA synthesis from single cells by performing lysis and cDNA synthesis in the same reaction tube and in one buffer solution, which provides reliable and contamination-free results. The buffer is composed of NP40, carrier-RNA and Super RNAsin, as well as dNTPs and cDNA synthesis primers.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: March 29, 2011
    Assignee: Philipps-Universitat Marburg
    Inventor: Birgit Liss