Patents Assigned to PRAXIS PRECISION MEDICINES, INC.
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Patent number: 11918571Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: March 4, 2022Date of Patent: March 5, 2024Assignee: Praxis Precision Medicines, Inc.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
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Patent number: 11866439Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: May 30, 2019Date of Patent: January 9, 2024Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy, Marion Wittmann
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Patent number: 11773099Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. The fused heteroaryl compounds of the disclosure are represented by Formula (I): wherein X, Y, Z, A, R1 and R2 are as defined in the specification. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.Type: GrantFiled: May 28, 2020Date of Patent: October 3, 2023Assignee: Praxis Precision Medicines, Inc.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
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Patent number: 11773088Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.Type: GrantFiled: November 2, 2021Date of Patent: October 3, 2023Assignee: Praxis Precision Medicines, Inc.Inventors: Gabriel Martinez Botella, Andrew Mark Griffin
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Patent number: 11767325Abstract: The present invention is directed to, in part, fused heteroaryl compounds of Formula (II-II): and compositions thereof, useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: November 25, 2020Date of Patent: September 26, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron, Carlos Loya
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Patent number: 11731976Abstract: The present invention is directed to 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trofluoroethoxy)pyridine-3-yl)-[1,2,4]triazolo[4,3-a]pyridine, or a pharmaceutically acceptable salt thereof, or a composition thereof, which is useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: March 26, 2021Date of Patent: August 22, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
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Patent number: 11731978Abstract: The present invention is directed to 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trofluoroethoxy)pyridine-3-yl)-[1,2,4]triazolo[4,3-?]pyridine, or a pharmaceutically acceptable salt thereof, or a composition thereof, which is useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: March 23, 2022Date of Patent: August 22, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
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Patent number: 11731966Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.Type: GrantFiled: April 4, 2018Date of Patent: August 22, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
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Patent number: 11697669Abstract: Disclosed herein are hemi-citrate salts of Compound 1, crystalline forms thereof, methods of their preparation, pharmaceutical compositions thereof, and methods of their use.Type: GrantFiled: May 25, 2022Date of Patent: July 11, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Doris Neville, Ahmad Hashash, Karl Hansen, Johann Chan
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Patent number: 11649207Abstract: Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.Type: GrantFiled: July 28, 2021Date of Patent: May 16, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventor: Preetam Ghogale
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Patent number: 11629146Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.Type: GrantFiled: November 28, 2017Date of Patent: April 18, 2023Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
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Patent number: 11505554Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: May 29, 2020Date of Patent: November 22, 2022Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy
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Patent number: 11492345Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.Type: GrantFiled: February 13, 2018Date of Patent: November 8, 2022Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
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Publication number: 20220280476Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.Type: ApplicationFiled: May 1, 2020Publication date: September 8, 2022Applicant: Praxis Precision Medicines, Inc.Inventors: Gabriel MARTINEZ BOTELLA, Andrew Mark GRIFFIN, Paul S. CHARIFSON, Kiran REDDY, Michael Kristopher Mathieu KAHLIG, Brian Edward MARRON
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Patent number: 11427540Abstract: Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.Type: GrantFiled: July 28, 2021Date of Patent: August 30, 2022Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Margaret S. Lee, Gabriel Maurice Belfort, Sapna Makhija Garad, Mahesh Padval, Randall Wagner
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Publication number: 20220259193Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.Type: ApplicationFiled: May 1, 2020Publication date: August 18, 2022Applicant: Praxis Precision Medicines, Inc.Inventors: Gabriel MARTINEZ BOTELLA, Andrew Mark GRIFFIN, Paul S. CHARIFSON, Kiran REDDY, Michael Kristopher Mathieu KAHLIG, Brian Edward MARRON
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Publication number: 20220241258Abstract: Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.Type: ApplicationFiled: July 10, 2020Publication date: August 4, 2022Applicant: Praxis Precision Medicines, Inc.Inventors: Kiran REDDY, Margaret S. LEE, Gabriel Maurice BELFORT, Sapna Makhija GARAD, Lisa HUANG, Mahesh PADVAL, Marion WITTMANN, Randall WAGNER
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Publication number: 20220135553Abstract: The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.Type: ApplicationFiled: November 2, 2021Publication date: May 5, 2022Applicant: Praxis Precision Medicines, Inc.Inventors: Gabriel MARTINEZ BOTELLA, Andrew Mark GRIFFIN
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Patent number: 11278535Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: August 15, 2018Date of Patent: March 22, 2022Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
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Patent number: 11279700Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.Type: GrantFiled: May 29, 2020Date of Patent: March 22, 2022Assignee: PRAXIS PRECISION MEDICINES, INC.Inventors: Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy