Abstract: Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified to include circuit components. The molecular circuits and cells containing the circuits can be used in a variety of applications including, e.g., diagnostics, therapeutics, and protein production.
Type:
Application
Filed:
October 23, 2009
Publication date:
August 5, 2010
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, TRUSTEES OF PRINCETON UNIVERSITY, Office of Technology Licensing and Intellectual Property
Inventors:
Yaakov Benenson, Ron Weiss, Leonidas Bleris, Zhen Xie
Abstract: The present invention provides a method and apparatus for increasing the intensity of coherent population trapping (CPT) resonances, used in atomic clocks and magnetometers, by pumping the atoms with light of alternating polarization. Pumping with such light, characterized by a photon spin vector that alternates in direction at a hyperfine frequency of the atoms at the location of the atoms, is referred to as push-pull pumping. In one embodiment of the system of the present invention, alkali-metal vapor is pumped with alternating circular-polarization D1 laser light that is intensity modulated at appropriate resonance frequencies, thereby exciting CPT resonances, which can be observed as increase in the mean transmittance of the alkali-metal vapor. These resonances are substantially enhanced due to an optically-induced concentration of atoms in the resonant energy sublevels.
Type:
Grant
Filed:
February 7, 2005
Date of Patent:
September 5, 2006
Assignee:
Princeton University, Office of Technology, Licensing & Intellectual Property
Inventors:
William Happer, Yuan-Yu Jau, Nicholas N. Kuzma, Eli Miron, Amber B. Post, Michael V. Romalis