Patents Assigned to Protein Design Labs, Inc.
  • Patent number: 5530101
    Abstract: Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: June 25, 1996
    Assignee: Protein Design Labs, Inc.
    Inventors: Cary L. Queen, Harold E. Selick
  • Patent number: 5349053
    Abstract: Chimeric molecules having a ligand component linked to an immunoglobulin constant region component are provided for various diagnostic, therapeutic and other uses. These immunoligands can exhibit the high degree of specificity associated with the ligand, yet retain various effector functions characteristic of immunoglobulin heavy chains.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: September 20, 1994
    Assignee: Protein Design Labs, Inc.
    Inventor: Nicholas F. Landolfi
  • Patent number: 5216132
    Abstract: Soluble antigens useful for efficient production of antibodies against human T-cell receptor epitopes are provided. A preferred antigen is a chimeric polypeptide comprising at least 100 amino acids from a V.beta. domain with solubility conferred by an immunoglobulin heavy chain CH2 or CH3 domain fused thereto. Product antibodies and methods for diagnostic and therapeutic uses for both antigens and antibodies are provided.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: June 1, 1993
    Assignee: Protein Design Labs, Inc.
    Inventor: Guriqbal S. Basi
  • Patent number: 5004692
    Abstract: Improved means for producing Clostridium Phospholipase C (PL) polypeptides based on the cloning and expression of recombinant DNA segments containing Clostridium PLC genes and fragments. The DNA segments are operably linked to host specific expression control sequences for exogenous production of Clostridium PLC, or fragments thereof, substantially free from naturally-associated Clostridium gene products.
    Type: Grant
    Filed: December 15, 1987
    Date of Patent: April 2, 1991
    Assignee: Protein Design Labs, Inc.
    Inventors: J. Yun Tso, Cary L. Queen