Patents Assigned to Protein Polymer Technologies, Inc.
  • Patent number: 7893229
    Abstract: Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: February 22, 2011
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Joseph Cappello
  • Publication number: 20090028813
    Abstract: Methods of treating body tissue including repairing defects in body tissue as well as augmenting body tissue. Body tissue defects are repaired by injecting a polymeric adhesive composition through an injector into the region of the defect and allowing the adhesive composition to cure to repair the defect or to form an implant that adheres to at least one surface tissue in the region of the defect. Body tissue is augmented by filling a defect void with a polymeric adhesive composition and allowing it to cure.
    Type: Application
    Filed: October 23, 2007
    Publication date: January 29, 2009
    Applicant: Protein Polymer Technologies, Inc.
    Inventors: Erwin R. Stedronsky, Joseph Cappello
  • Publication number: 20090023648
    Abstract: Methods of treating body tissue including repairing defects in body tissue as well as augmenting body tissue. Body tissue defects are repaired by injecting a polymeric adhesive composition through an injector into the region of the defect and allowing the adhesive composition to cure to repair the defect or to form an implant that adheres to at least one surface tissue in the region of the defect. Body tissue is augmented by filling a defect void with a polymeric adhesive composition and allowing it to cure.
    Type: Application
    Filed: October 23, 2007
    Publication date: January 22, 2009
    Applicant: Protein Polymer Technologies, Inc.
    Inventors: Edwin R. Stredonsky, Joseph Cappello
  • Patent number: 7300663
    Abstract: Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: November 27, 2007
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Erwin R. Stedronsky, Joseph Cappello
  • Patent number: 7285580
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: October 23, 2007
    Assignee: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Publication number: 20050129745
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Application
    Filed: January 25, 2005
    Publication date: June 16, 2005
    Applicant: Protein Polymer Technologies, Inc.
    Inventor: Erwin Stedronsky
  • Patent number: 6875796
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: April 5, 2005
    Assignee: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Publication number: 20030176355
    Abstract: Methods and compositions are provided which are useful for delivering a biologically active substance to a localized site in vivo and for altering the physical dimensions of a body tissue. These methods and compositions employ protein polymers having varying ratios of elastin-like, collagen-like, keratin-like repeating units and repeating units which promote protein crystallization such as silk-like repeating units. By varying the length of segments of the repeating units and/or the concentration of the protein polymers in the composition, the rate of delivery of a biologically active substance to a localized site can be greatly varied. Moreover, because the compositions are capable of acquiring a non-liquid form under normal physiological conditions, they find use as biocompatible tissue augmentation products.
    Type: Application
    Filed: April 22, 2002
    Publication date: September 18, 2003
    Applicant: Protein Polymer Technologies, Inc.
    Inventors: Joseph Cappello, Erwin R. Stedronsky
  • Patent number: 6576685
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: June 10, 2003
    Assignee: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Publication number: 20030083464
    Abstract: Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
    Type: Application
    Filed: March 12, 2002
    Publication date: May 1, 2003
    Applicant: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Charles Richardson, James Chambers, Stuart Causey, Thomas J. Pollock, Joseph Cappello, John W. Crissman
  • Patent number: 6423333
    Abstract: Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesive compositions for bonding together separated tissue, and for sealing or filling tissue defects by injecting the compositions into the defects. Particularly, block copolymers having repeating units of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents such as glutaraldehyde, activated diolefins, diisocyanates, acid anhydrides or diamines. The protein polymer contains at least 40 weight percent of repetitive units of 3 to 30 amino acids, preferably 3 to 15 amino acids, of at least one naturally occurring structural protein and at least two amino acids containing a functional group capable of reacting with the crosslinking agent.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: July 23, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Erwin R. Stedronsky, Joseph Cappello
  • Publication number: 20020058733
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Application
    Filed: June 22, 2001
    Publication date: May 16, 2002
    Applicant: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Patent number: 6380154
    Abstract: Method and compositions are provided which are useful for delivering a biologically active substance to a localized site in vivo and for altering the physical dimensions of a body tissue. These method and compositions employ protein polymers having varying ratios of elastin-like collagen-like, keratin-like repeating units and repeating units which promote protein crystallization such as silk-like repeating units. By varying the length of segments of the repeating units and/or the concentration of the protein polymers in the composition, the rate of delivery of a biologically active substance to a localized site can be greatly varied. Moreover, because the compositions are capable of acquiring a non-liquid form under normal physiological conditions, they find use as biocompatible tissue augmentation products.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: April 30, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Joseph Cappello, Erwin R. Stedronsky
  • Patent number: 6355776
    Abstract: Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: March 12, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Charles Richardson, James Chambers, Stuart Causey, Thomas J. Pollock, Joseph Cappello, John W. Crissman
  • Patent number: 6258872
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: July 10, 2001
    Assignee: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Patent number: 6140072
    Abstract: Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 31, 2000
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Joseph Cappello
  • Patent number: 6018030
    Abstract: Polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 25, 2000
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Charles Richardson, James Chambers, Stuart Causey, Thomas J. Pollock, Joseph Cappello, John W. Crissman
  • Patent number: 5830713
    Abstract: Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: November 3, 1998
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Joseph Cappello, John W. Crissman, Mary A. Dorman
  • Patent number: 5817303
    Abstract: Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers having repeating units of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents. The protein polymer contains at least 40 weight percent of repetitive units of 3 to 15 amino acids of at least one naturally occurring protein and in at least two units an amino acid is substituted by an amino acid containing a functional group capable of reacting with a crosslinking agent to form a strongly adherent adhesive composition for bonding together separated tissue or for sealing tissue defects.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: October 6, 1998
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Erwin R. Stedronsky, Joseph Cappello
  • Patent number: 5808012
    Abstract: Thermoplastics interdispersed with a variety of functional thermostable proteins and methods for their production are provided. To prepare the subject thermoplastics, a plastic material is contacted with a thermostable polypeptide and then subjected to the heating and molding/extrusion/casting process. The resultant thermoplastics comprise the thermostable polypeptide on the formed plastic surface and at a depth below the plastic surface. The thermostable polypeptides contained in the disclosed compositions retain functional properties or binding specificities through the heating and molding/extrusion/casting processes. Preferred thermostable polypeptides used in the disclosed compositions include silk-like protein polymers, particularly ProNectin.RTM.F. The disclosed methods and compositions find use in many applications where plastics containing finctional thermostable proteins are desired, in particular, cell cultureware.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: September 15, 1998
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: David M. Donofrio, Erwin R. Stedronsky