Patents Assigned to QUÍMICA SINTÉTICA, S.A.
  • Process for the preparation of ferric organic compounds
    Patent number: 11926586
    Abstract: A highly pure form of ferric citrate and an industrially viable and advantageous process for its preparation are described.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: March 12, 2024
    Assignee: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe Barreca, Luca Carcone, Norberto Masciocchi
  • Process for the preparation of sphingosine-1-phosphate receptor agonist
    Patent number: 11465977
    Abstract: Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: October 11, 2022
    Assignee: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe Barreca, Luca Carcone, Maurizio Taddei, Damian Mark Grainger, Samantha Louise Staniland, Claudio Cianferotti, Giovanni Marras
  • PROCESS FOR THE PREPARATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST
    Publication number: 20220033365
    Abstract: Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.
    Type: Application
    Filed: September 25, 2019
    Publication date: February 3, 2022
    Applicant: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe BARRECA, Luca CARCONE, Maurizio TADDEI, Damian Mark GRAINGER, Samantha Louise STANILAND, Claudio CIANFEROTTI, Giovanni MARRAS
  • Resolution of racemic beta-aminosulfone compounds
    Patent number: 11149003
    Abstract: It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 19, 2021
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Bruno Romanò
  • Eluxadoline crystalline forms and processes for their preparation
    Patent number: 10738013
    Abstract: Novel crystalline forms of Eluxadoline, having the formula (I), are described. Also described are the processes for the preparation of said crystalline forms.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 11, 2020
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giampiero Ventimiglia, Norberto Masciocchi
  • RESOLUTION OF RACEMIC BETA-AMINOSULFONE COMPOUNDS
    Publication number: 20200199072
    Abstract: It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Application
    Filed: March 28, 2018
    Publication date: June 25, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Bruno Romanò
  • Racemic beta-aminosulfone compounds
    Patent number: 10689332
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 23, 2020
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • AMORPHOUS POWDER COMPRISING AN ANGIOTENSIN RECEPTOR BLOCKER AND A NEUTRAL ENDOPEPTIDASE INHIBITOR
    Publication number: 20200179290
    Abstract: Several methods for the preparation of an amorphous powder that includes a 1:1 stoichiometric mixture of the trisodium salts of Valsartan and Sacubitril are described, as well as the resulting amorphous powder, pharmaceutical compositions containing it, and their use in the treatment of essential hypertension and/or cardiac failure.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 11, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giampiero Ventimiglia, Sonja Bellomi
  • Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines
    Patent number: 10597353
    Abstract: The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: March 24, 2020
    Assignee: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe Barreca, Marcello Rasparini, Luca Carcone, Fabio Morana
  • RACEMIC BETA-AMINOSULFONE COMPOUNDS
    Publication number: 20200087254
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Application
    Filed: March 28, 2018
    Publication date: March 19, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • ELUXADOLINE CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20190345114
    Abstract: Novel crystalline forms of Eluxadoline, having the formula (I), are described. Also described are the processes for the preparation of said crystalline forms.
    Type: Application
    Filed: January 26, 2018
    Publication date: November 14, 2019
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giampiero Ventimiglia, Norberto Masciocchi
  • Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof
    Patent number: 10407456
    Abstract: Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: September 10, 2019
    Assignee: QUIMICA SINTETICA, S.A.
    Inventors: Giuseppe Barreca, Marcello Rasparini, Andrea Poggiali, Luca Carcone, Roberto Rocco Tufaro, Giovanni Marras, Maurizio Taddei, Elena Cini
  • AMORPHOUS POWDER COMPRISING AN ANGIOTENSIN RECEPTOR BLOCKER AND A NEUTRAL ENDOPEPTIDASE INHIBITOR
    Publication number: 20180353430
    Abstract: Several methods for the preparation of an amorphous powder comprising a 1:1 stoichiometric mixture of the trisodium salts of Valsartan and Sacubitril are described, as well as the resulting amorphous powder, pharmaceutical compositions containing it, and their use in the treatment of essential hypertension and/or cardiac failure.
    Type: Application
    Filed: July 12, 2016
    Publication date: December 13, 2018
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giampiero Ventimiglia, Sonja Bellomi
  • Process for the preparation of (1S,2R)-Milnacipran
    Patent number: 10131624
    Abstract: The invention relates to a process for the preparation of Levomilnacipran or salts thereof, compounds useful in the treatment of depression, with high yield.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: November 20, 2018
    Assignee: QUIMICA SINTETICA, S.A.
    Inventors: Giuseppe Barreca, Bruno Gaetano Romano
  • Process For Obtaining Levofloxacin Free From Salts
    Publication number: 20090069560
    Abstract: This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C1-C4)alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts, without need to carry out any final step of extraction and without using halogenated solvents. One characteristic of the process described is that no extractions are necessary in the final step of the process.
    Type: Application
    Filed: December 15, 2005
    Publication date: March 12, 2009
    Applicant: Quimica Sintetica, S.A.
    Inventors: Francisco Palomo Nicolau, Antonio Cosme Gomez, Rafael Martin Sanchez
  • Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo- [1,2-a]-pyridine- 3-acetamide and salts thereof
    Patent number: 6407240
    Abstract: It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducing agent to form the ester of formula (XII), which is then reacted with dimethylamine in a polyhydroxylated solvent medium at an appropriate
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: June 18, 2002
    Assignee: Quimica Sintetica, S.A.
    Inventor: Rafael Labriola