Patents Assigned to Quadrant Drug Delivery Limited
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Patent number: 9827205Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.Type: GrantFiled: December 12, 2009Date of Patent: November 28, 2017Assignees: Mallinckrodt Pharma IP Trading D.A.C., Quadrant Drug Delivery LimitedInventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
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Publication number: 20170182135Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.Type: ApplicationFiled: March 10, 2017Publication date: June 29, 2017Applicant: Quadrant Drug Delivery LimitedInventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
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Publication number: 20110150927Abstract: A micro-particulate dry powder composition comprising a viral particle can be prepared by spray-drying a mixture of the viral particle and a stabilizing carbohydrate using an outlet temperature of no more than 60° C.Type: ApplicationFiled: July 30, 2010Publication date: June 23, 2011Applicant: QUADRANT DRUG DELIVERY LIMITEDInventor: CHRISTOPHER IAIN GRAINGER
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Patent number: 7785631Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.Type: GrantFiled: May 20, 2005Date of Patent: August 31, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Patent number: 7780991Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.Type: GrantFiled: May 20, 2005Date of Patent: August 24, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Patent number: 7744925Abstract: The present invention encompasses a therapeutic composition in solid dose form that is suitable for pulmonary administration. The therapeutic composition may comprise therapeutic particles in a glassy state. The therapeutic composition preferably comprises a bioactive material such as insulin, and a sugar alcohol. The components are optionally in solid solution. The therapeutic composition can preferably remain in a glassy state when stored at elevated temperatures, and/or extended periods.Type: GrantFiled: May 20, 2005Date of Patent: June 29, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Patent number: 7501493Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.Type: GrantFiled: August 20, 2007Date of Patent: March 10, 2009Assignee: Quadrant Drug Delivery LimitedInventor: Bruce Joseph Roser
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Publication number: 20090004275Abstract: A composition for oromucosal delivery of a biologically active agent, which composition releases the active agent within 5 minutes when applied to an oramucosal surface in use, comprises a biologically active agent and a matrix-former. The biologically active agent may be present as an ion pair complex.Type: ApplicationFiled: July 29, 2005Publication date: January 1, 2009Applicant: Quadrant Drug Delivery LimitedInventors: Glen Patrick Martyn, David St. John Coghlan
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Patent number: 7381796Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.Type: GrantFiled: March 23, 2007Date of Patent: June 3, 2008Assignee: Quadrant Drug Delivery LimitedInventor: Bruce Joseph Roser
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Patent number: 7244824Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.Type: GrantFiled: October 8, 2003Date of Patent: July 17, 2007Assignee: Quadrant Drug Delivery LimitedInventor: Bruce Joseph Roser
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Patent number: 7244825Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.Type: GrantFiled: September 8, 2003Date of Patent: July 17, 2007Assignee: Quadrant Drug Delivery LimitedInventor: Bruce Joseph Roser
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Patent number: 7220836Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.Type: GrantFiled: October 6, 2003Date of Patent: May 22, 2007Assignee: Quadrant Drug Delivery LimitedInventor: Bruce Joseph Roser
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Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
Patent number: 7153472Abstract: This invention relates to formulations comprising biological samples preserved as dry glassy powders and hydrophobic carriers, the formulations being adapted for the long-term storage and delivery of the bioactive materials, in particular viral and bacterial vaccines, vectors and cells, at ambient or higher temperatures, and to methods for preparing these formulations.Type: GrantFiled: November 22, 2000Date of Patent: December 26, 2006Assignee: Quadrant Drug Delivery LimitedInventor: Victor Bronshtein -
Publication number: 20050255051Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.Type: ApplicationFiled: July 22, 2005Publication date: November 17, 2005Applicant: Quadrant Drug Delivery LimitedInventors: Stuart Robinson, Susan Smith
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Publication number: 20050238586Abstract: Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 ?m, targeted to selected areas of the body or of prolonged life in the circulation.Type: ApplicationFiled: June 23, 2005Publication date: October 27, 2005Applicant: Quadrant Drug Delivery LimitedInventors: Andrew Sutton, Richard Johnson
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Patent number: 6939530Abstract: Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 ?m, targeted to selected areas of the body or of prolonged life in the circulation.Type: GrantFiled: June 21, 2002Date of Patent: September 6, 2005Assignee: Quadrant Drug Delivery LimitedInventors: Andrew Derek Sutton, Richard Alan Johnson
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Publication number: 20050192216Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.Type: ApplicationFiled: September 8, 2003Publication date: September 1, 2005Applicant: Quadrant Drug Delivery LimitedInventor: Bruce Roser
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Patent number: 6926908Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.Type: GrantFiled: August 12, 2002Date of Patent: August 9, 2005Assignee: Quadrant Drug Delivery LimitedInventors: Stuart Robinson, Susan Stewart Smith
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Publication number: 20050101533Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.Type: ApplicationFiled: October 6, 2003Publication date: May 12, 2005Applicant: Quadrant Drug Delivery LimitedInventor: Bruce Roser
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Patent number: 6872357Abstract: This invention relates to formulations and methods for preserving sensitive biologicals, viruses, bacteria and eukaryotic cells by drying. More particularly, the invention relates to preservation mixtures containing viruses or cells and protectants, including a combination of a methylated monosaccharide and a disaccharide, or oligosaccharide, wherein the mixtures are adapted to stabilize these during dehydration and subsequent storage at ambient and higher temperature.Type: GrantFiled: November 22, 2000Date of Patent: March 29, 2005Assignee: Quadrant Drug Delivery LimitedInventors: Victor Bronshtein, Lynn Linkowski