Patents Assigned to Quadrant Drug Delivery Limited
  • Patent number: 9827205
    Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.
    Type: Grant
    Filed: December 12, 2009
    Date of Patent: November 28, 2017
    Assignees: Mallinckrodt Pharma IP Trading D.A.C., Quadrant Drug Delivery Limited
    Inventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
  • Publication number: 20170182135
    Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.
    Type: Application
    Filed: March 10, 2017
    Publication date: June 29, 2017
    Applicant: Quadrant Drug Delivery Limited
    Inventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
  • Publication number: 20110150927
    Abstract: A micro-particulate dry powder composition comprising a viral particle can be prepared by spray-drying a mixture of the viral particle and a stabilizing carbohydrate using an outlet temperature of no more than 60° C.
    Type: Application
    Filed: July 30, 2010
    Publication date: June 23, 2011
    Applicant: QUADRANT DRUG DELIVERY LIMITED
    Inventor: CHRISTOPHER IAIN GRAINGER
  • Patent number: 7785631
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: August 31, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Patent number: 7780991
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: August 24, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Patent number: 7744925
    Abstract: The present invention encompasses a therapeutic composition in solid dose form that is suitable for pulmonary administration. The therapeutic composition may comprise therapeutic particles in a glassy state. The therapeutic composition preferably comprises a bioactive material such as insulin, and a sugar alcohol. The components are optionally in solid solution. The therapeutic composition can preferably remain in a glassy state when stored at elevated temperatures, and/or extended periods.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: June 29, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Patent number: 7501493
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 10, 2009
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Publication number: 20090004275
    Abstract: A composition for oromucosal delivery of a biologically active agent, which composition releases the active agent within 5 minutes when applied to an oramucosal surface in use, comprises a biologically active agent and a matrix-former. The biologically active agent may be present as an ion pair complex.
    Type: Application
    Filed: July 29, 2005
    Publication date: January 1, 2009
    Applicant: Quadrant Drug Delivery Limited
    Inventors: Glen Patrick Martyn, David St. John Coghlan
  • Patent number: 7381796
    Abstract: A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: June 3, 2008
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7244825
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: July 17, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7244824
    Abstract: A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: July 17, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7220836
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: May 22, 2007
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Bruce Joseph Roser
  • Patent number: 7153472
    Abstract: This invention relates to formulations comprising biological samples preserved as dry glassy powders and hydrophobic carriers, the formulations being adapted for the long-term storage and delivery of the bioactive materials, in particular viral and bacterial vaccines, vectors and cells, at ambient or higher temperatures, and to methods for preparing these formulations.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: December 26, 2006
    Assignee: Quadrant Drug Delivery Limited
    Inventor: Victor Bronshtein
  • Publication number: 20050255051
    Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.
    Type: Application
    Filed: July 22, 2005
    Publication date: November 17, 2005
    Applicant: Quadrant Drug Delivery Limited
    Inventors: Stuart Robinson, Susan Smith
  • Publication number: 20050238586
    Abstract: Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 ?m, targeted to selected areas of the body or of prolonged life in the circulation.
    Type: Application
    Filed: June 23, 2005
    Publication date: October 27, 2005
    Applicant: Quadrant Drug Delivery Limited
    Inventors: Andrew Sutton, Richard Johnson
  • Patent number: 6939530
    Abstract: Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 ?m, targeted to selected areas of the body or of prolonged life in the circulation.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: September 6, 2005
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Andrew Derek Sutton, Richard Alan Johnson
  • Publication number: 20050192216
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Application
    Filed: September 8, 2003
    Publication date: September 1, 2005
    Applicant: Quadrant Drug Delivery Limited
    Inventor: Bruce Roser
  • Patent number: 6926908
    Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: August 9, 2005
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Stuart Robinson, Susan Stewart Smith
  • Publication number: 20050101533
    Abstract: A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
    Type: Application
    Filed: October 6, 2003
    Publication date: May 12, 2005
    Applicant: Quadrant Drug Delivery Limited
    Inventor: Bruce Roser
  • Patent number: 6872357
    Abstract: This invention relates to formulations and methods for preserving sensitive biologicals, viruses, bacteria and eukaryotic cells by drying. More particularly, the invention relates to preservation mixtures containing viruses or cells and protectants, including a combination of a methylated monosaccharide and a disaccharide, or oligosaccharide, wherein the mixtures are adapted to stabilize these during dehydration and subsequent storage at ambient and higher temperature.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: March 29, 2005
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Victor Bronshtein, Lynn Linkowski