Patents Assigned to Quest Diagnostics
  • BCR-ABL TRUNCATION MUTATIONS
    Publication number: 20170137884
    Abstract: Truncation variants of BCR-ABL mRNA that produces BCR-ABL proteins with a truncated C-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cDNA constructs. Also provided are methods compositions and kits for detecting the BCR-ABL truncation variants. Also provided are methods for determining the prognosis of a patient diagnosed as having myeloproliferative disease, and methods for predicting the likelihood for resistance to a treatment with tyrosine kinase inhibitor in a patient diagnosed as having myeloproliferative disease. Additionally, methods for screening BCR-ABL tyrosine kinase domain inhibitors which rely on the recombinant cells are also disclosed.
    Type: Application
    Filed: November 3, 2016
    Publication date: May 18, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maher Albitar, Wanlong Ma
  • Methods for the diagnosis of bacterial vaginosis
    Publication number: 20170137867
    Abstract: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.
    Type: Application
    Filed: October 31, 2016
    Publication date: May 18, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Erik P. Johnson, Dale A. Schwab
  • Methods for detecting vitamin C by mass spectrometry
    Patent number: 9645158
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: May 9, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 9625477
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: April 18, 2017
    Assignee: Quest Diagnostics Invstments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke, Richard E. Reitz
  • AMYLOID BETA DETECTION BY MASS SPECTROMETRY
    Publication number: 20170089917
    Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 30, 2017
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Diana Tran, Darren Weber, Nigel Clarke
  • MICRORNA PROFILING FOR DIAGNOSIS OF DYSPLASTIC NEVI AND MELANOMA
    Publication number: 20170088899
    Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.
    Type: Application
    Filed: August 5, 2016
    Publication date: March 30, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
  • DIRECT AMPLIFICATION AND DETECTION OF VIRAL AND BACTERIAL PATHOGENS
    Publication number: 20170081735
    Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods as-saying saying extracted nucleic acids.
    Type: Application
    Filed: October 7, 2016
    Publication date: March 23, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
  • MICRORNA PROFILING FOR DIAGNOSIS OF DYSPLASTIC NEVI AND MELANOMA
    Publication number: 20170081725
    Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.
    Type: Application
    Filed: August 18, 2016
    Publication date: March 23, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Kevin Qu, Anthony Sferruzza, Ke Zhang, Yan Liu, Renius Owen
  • C peptide detection by mass spectrometry
    Patent number: 9594074
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. The present invention provides methods for detecting the presence or amount of C peptide in a sample by mass spectrometry.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: March 14, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Thyroglobulin quantitation by mass spectroscopy
    Patent number: 9580740
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: February 28, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Kisspeptin-54 detection by tandem mass spectrometry
    Patent number: 9583322
    Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 28, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory E. Bystrom, Richard E. Reitz
  • WORKSPACE FOR PERFORMING LIQUID CHROMOTOGRAPHY ANALYSIS
    Publication number: 20170049225
    Abstract: A work space apparatus for performing scientific analysis having a plurality of modules coupled to an upper region of a desk surface and a top surface coupled to and vertically above the plurality of modules. Each of the plurality of modules has a width defined by a first sidewall and second sidewall and a height that is adjustable.
    Type: Application
    Filed: August 19, 2016
    Publication date: February 23, 2017
    Applicant: Quest Diagnostics Investments LLC
    Inventor: Laura Chau
  • ASSAYS AND METHODS FOR THE DIAGNOSIS OF POST-STREPTOCOCCAL DISORDERS
    Publication number: 20170045511
    Abstract: Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.
    Type: Application
    Filed: May 18, 2016
    Publication date: February 16, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Stanley J. Naides, Joanna Popov
  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE MUTATIONS
    Publication number: 20170022566
    Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. The mutations include duplication of exons including duplication of exons 6b through 10. Methods of identifying if an individual contains the exons 6b through 10 duplication are provided as well as nucleic acid fragments that contain the junction site of the duplicated segment. The detection of additional mutations in the CFTR gene are also provided.
    Type: Application
    Filed: July 28, 2016
    Publication date: January 26, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Feras Hantash
  • DETECTING GENETIC COPY NUMBER VARIATION
    Publication number: 20170009287
    Abstract: Embodiments of the invention include systems, apparatus, and methods for detecting copy number variation (CNV) in the genomes of one or more patients. Samples of DNA may be taken from several patients, and then sections of the patients' DNA may be sequenced, e.g., through a process that may include, for each patient, one or more of: purifying, concentrating, fragmenting, labeling, filtering, and amplifying that patient's DNA. Fragments from several patients may be pooled, and the fragments in the pool may be sequenced. The sequencing data is then subjected to analysis, which includes several normalization steps. The normalized data are then examined to identify CNV, which is reported.
    Type: Application
    Filed: July 8, 2015
    Publication date: January 12, 2017
    Applicant: Quest Diagnostics investments Incorporated
    Inventors: Corey Brastaad, Christopher D. Elzinga, Mingsheng Zhang, Matthew C. Evans
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 9541562
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 10, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • METHOD TO DETECT REPEAT SEQUENCE MOTIFS IN NUCLEIC ACID
    Publication number: 20170002416
    Abstract: Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5?-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.
    Type: Application
    Filed: June 6, 2016
    Publication date: January 5, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Feras Hantash, Weimin Sun, David C. Tsao, Dana Marie Root, Charles M. Strom
  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE MUTATIONS
    Publication number: 20170002418
    Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
    Type: Application
    Filed: July 18, 2016
    Publication date: January 5, 2017
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Weimin Sun, Matthew J. McGinniss, Donghui Huang, Arlene Buller, Raymond Fenwick, Mei Peng, Franklin Quan
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 9535077
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: January 3, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 9529004
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally are directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 27, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz