Patents Assigned to Quest Diagnostics
  • DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN BIOLOGICAL SAMPLES
    Publication number: 20240026467
    Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.
    Type: Application
    Filed: June 12, 2023
    Publication date: January 25, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Lakshmi NAIR, Heather VINCENT, Huong MAI, Michelle TABB, Maurice EXNER
  • ASSAYS AND METHODS FOR THE DIAGNOSIS OF POST-STREPTOCOCCAL DISORDERS
    Publication number: 20240019433
    Abstract: Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagnosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.
    Type: Application
    Filed: September 25, 2023
    Publication date: January 18, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Stanley J. NAIDES, Joanna Popov
  • Visual presentation of multi-dimensional data sets
    Patent number: 11875025
    Abstract: Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. The ocular view may depict the relationships between the tests and the systems. By being generated dynamically, moreover, the ocular view may be able to present this information for arbitrary sets of test results, without a template having been generated in advance to specify the layout of some particular combination of results.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: January 16, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Peter Wilkinson, Kerry O'Brien
  • Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry
    Patent number: 11860141
    Abstract: Provided are methods for detecting or determining the amount of guanidinoacetate (GAA), creatine, and creatinine by mass spectrometry.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: January 2, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventor: Thomas C. Lynn
  • AUTOMATED ANALYSIS OF ANALYTICAL GELS AND BLOTS
    Publication number: 20230417700
    Abstract: The present solution describes an automated system for analyzing analytical gels or blots, such as electrophoresis gels. The system can automatically detect the lanes within the gel and convert the lane into a feature vector that can be compared to reference datasets. Based on a comparison of the feature vector to the reference datasets, the system can automatically classify the feature vector (and the test sample in the lane) into a phenotype group.
    Type: Application
    Filed: June 26, 2023
    Publication date: December 28, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Nilesh Saratkar, Stanley Naides, Michelle A. Cleveland
  • EML4-ALK TRANSLOCATIONS IN LUNG CANCER
    Publication number: 20230416835
    Abstract: The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are analyzed for the presence of one or more specific EML4-ALK fusion genes associated with neoplastic disorders.
    Type: Application
    Filed: May 1, 2023
    Publication date: December 28, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • Direct amplification and detection of viral and bacterial pathogens
    Patent number: 11851720
    Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: December 26, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
  • DIAGNOSIS OF PROSTATE CANCER
    Publication number: 20230407289
    Abstract: The invention provides methods for isolating RNA from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia. An exemplary method for diagnosing prostate cancer in an individual, said method comprises: (a) determining the amount of RNA encoding one or more diagnostic genes in the soluble urine fraction of a urine sample obtained from said individual; (b) comparing the amount of said RNA to a reference value for said one or more diagnostic genes, wherein said reference value is derived from the amount of RNA encoding said one or more diagnostic genes in one or more individuals that do not have prostate cancer; and (c) diagnosing said individual as having prostate cancer when the amount of said RNA is greater than said reference value.
    Type: Application
    Filed: June 5, 2023
    Publication date: December 21, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventor: Heather R. SANDERS
  • MLH1 methylation assay
    Patent number: 11840726
    Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: December 12, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Amber C. Donahue, Feras Hantash
  • Mass spectrometric determination of fatty acids
    Patent number: 11830715
    Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: November 28, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Scott Goldman
  • Hematopoietic cell phenotyping using circulating cell-free markers
    Patent number: 11828760
    Abstract: The present invention provides methods of classifying cluster of differentiation (CD) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free CD markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of CD and other markers in bodily fluids of a patient.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: November 28, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventor: Maher Albitar
  • Vitamin B2 detection by mass spectrometry
    Patent number: 11821889
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: November 21, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Changming Yang, Sum Chan
  • Mass spectrometry of steroidal compounds in multiplexed patient samples
    Patent number: 11808773
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: November 7, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Kits for detecting nucleic acid
    Patent number: 11802317
    Abstract: Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M. avium and M. intracellulare. Also described are oligonucleotides that can be used as primers to amplify target genes such as mig and DT1 genes and as probes as well as kits containing the oligonucleotide.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: October 31, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Edgar Ong, Maurice Exner
  • Mass spectrometry method for measuring vitamin B6 in body fluid
    Patent number: 11798794
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: October 24, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Sum Chan, Richard E. Reitz
  • SYSTEMS AND METHODS FOR ELECTRONICALLY DISTRIBUTING INFORMATION
    Publication number: 20230336511
    Abstract: Embodiments of the invention include systems and methods for transmitting messages related to certain information while maintaining the confidentiality of that information. A potential recipient may register one or more devices for receipt of such messages while specifying rules regarding when different messages may be delivered to the various devices. To keep sensitive information confidential, the messages may include only a link to such sensitive information, but exclude the sensitive information itself. An authorized recipient may then use the link to access the sensitive information via a password-protected Web site.
    Type: Application
    Filed: June 22, 2023
    Publication date: October 19, 2023
    Applicant: Quest Diagnostics Investments Inc.
    Inventors: Douglas Menkedick, David Rapperport, Maheswar Putta
  • C peptide detection by mass spectrometry
    Patent number: 11789026
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: October 17, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • QUANTITATION OF INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-LIKE GROWTH FACTOR-II WITH HIGH-RESOLUTION MASS SPECTROMETRY
    Publication number: 20230324414
    Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution / high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution / high accuracy mass spectrometry.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 12, 2023
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard Reitz
  • Method of detecting anti-Ri in a subject with a previous streptococcal infection
    Patent number: 11768202
    Abstract: Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 26, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Stanley J. Naides, Joanna Popov
  • METHODS FOR DETECTING NOROVIRUS
    Publication number: 20230279513
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: January 13, 2023
    Publication date: September 7, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb