Patents Assigned to Quest Diagnostics
  • MASS SPECTROMETRIC DETERMINATION OF TESTOSTERONE IN MULTIPLEXED PATIENT SAMPLES
    Publication number: 20230273226
    Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
    Type: Application
    Filed: May 4, 2023
    Publication date: August 31, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Mildred M. Goldman, Scott Goldman, Julia Colletti, Nigel Clarke
  • VISUAL PRESENTATION OF MULTI-DIMENSIONAL DATA SETS
    Publication number: 20230266867
    Abstract: Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. The ocular view may depict the relationships between the tests and the systems. By being generated dynamically, moreover, the ocular view may be able to present this information for arbitrary sets of test results, without a template having been generated in advance to specify the layout of some particular combination of results.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 24, 2023
    Applicant: Quest Diagnostics Investments Inc.
    Inventors: Peter Wilkinson, Kerry O'Brien
  • METHODS FOR CELL-FREE DNA EXTRACTION FOR NON-INVASIVE PRENATAL SCREENING
    Publication number: 20230265414
    Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.
    Type: Application
    Filed: October 31, 2022
    Publication date: August 24, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Ben ANDERSON, Charles STROM, David TSAO, Yan LIU, Weimin SUN
  • METHOD TO DETECT REPEAT SEQUENCE MOTIFS IN NUCLEIC ACID
    Publication number: 20230265510
    Abstract: Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5?-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.
    Type: Application
    Filed: October 10, 2022
    Publication date: August 24, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Feras Hantash, Weimin Sun, David C. Tsao, Dana Marie Root, Charles M Strom
  • METHYLATED MARKERS FOR COLORECTAL CANCER
    Publication number: 20230212685
    Abstract: Disclosed herein is a combination of genomic sequences whose methylation patterns have utility for the improved detection and differentiation between colorectal neoplasms. Further disclosed herein are methods, nucleic acids and kits for detecting or differentiating between colorectal neoplasms.
    Type: Application
    Filed: October 31, 2022
    Publication date: July 6, 2023
    Applicants: Quest Diagnostics Investments LLC, Clinical Genomics PTY Ltd
    Inventors: Susanne PEDERSEN, Lawrence LaPOINTE, Rohan BAKER, Amber C. DONAHUE, Yen-lin PENG, Frederic WALDMAN
  • Automated analysis of analytical gels and blots
    Patent number: 11686703
    Abstract: The present solution describes an automated system for analyzing analytical gels or blots, such as electrophoresis gels. The system can automatically detect the lanes within the gel and convert the lane into a feature vector that can be compared to reference datasets. Based on a comparison of the feature vector to the reference datasets, the system can automatically classify the feature vector (and the test sample in the lane) into a phenotype group.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 27, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Nilesh Saratkar, Stanley Naides, Michelle A. Cleveland
  • COMPOSITIONS AND METHODS FOR DETERMINING ENDOMETRIAL CANCER PROGNOSIS
    Publication number: 20230193358
    Abstract: The present invention provides methods and compositions for determining prognosis in individual with cancer, in particular endometrial cancer. The present invention also provides methods of developing and using predictive models that are useful for determining prognosis of endometrial cancer and other similar diseases. The present invention further provides methods for determining microsatellite status using next generation sequencing.
    Type: Application
    Filed: February 21, 2023
    Publication date: June 22, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Yongbao WANG, Kevin J. ARVAI, Daniel JONES
  • Lipoprotein analysis by differential charged-particle mobility
    Patent number: 11680949
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: June 20, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Richard E Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell
  • METHODS FOR QUANTITATION OF INSULIN LEVELS BY MASS SPECTROMETRY
    Publication number: 20230184740
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: October 31, 2022
    Publication date: June 15, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Steven W. TAYLOR, Michael McPHAUL, Richard E. REITZ, Zhaohui CHEN, Nigel J. CLARKE
  • Mass spectrometric determination of testosterone in multiplexed patient samples
    Patent number: 11674969
    Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 13, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Mildred M. Goldman, Scott Goldman, Julia Colletti, Nigel Clarke
  • Detection of methicillin-resistant in biological samples
    Patent number: 11674189
    Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: June 13, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Lakshmi Nair, Heather Vincent, Huong Mai, Michelle Tabb, Maurice Exner
  • Diagnosis of prostate cancer
    Patent number: 11667909
    Abstract: The invention provides methods for isolating RNA from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia. An exemplary method for diagnosing prostate cancer in an individual, said method comprises: (a) determining the amount of RNA encoding one or more diagnostic genes in the soluble urine fraction of a urine sample obtained from said individual; (b) comparing the amount of said RNA to a reference value for said one or more diagnostic genes, wherein said reference value is derived from the amount of RNA encoding said one or more diagnostic genes in one or more individuals that do not have prostate cancer; and (c) diagnosing said individual as having prostate cancer when the amount of said RNA is greater than said reference value.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: June 6, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventor: Heather R. Sanders
  • Visual presentation of multi-dimensional data sets
    Patent number: 11669228
    Abstract: Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. The ocular view may depict the relationships between the tests and the systems. By being generated dynamically, moreover, the ocular view may be able to present this information for arbitrary sets of test results, without a template having been generated in advance to specify the layout of some particular combination of results.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: June 6, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Peter Wilkinson, Kerry O'Brien
  • Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
    Patent number: 11650216
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 16, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke, Anne Caston, Richard E. Reitz
  • METHOD FOR DIRECT MICROBIAL IDENTIFICATION
    Publication number: 20230143248
    Abstract: Described herein are methods for direct detection of microbial agent(s) in a polymicrobial sample, such as a biological sample from a human, without culturing the microbial agent(s). The direct detection can identify mixtures of bacteria and/or fungi in the sample. Also described are primer sequences and amplification techniques for performing the direct detection methods.
    Type: Application
    Filed: August 22, 2022
    Publication date: May 11, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Erik P. Johnson, Nik Isely, Jamie L. Platt, Martin Siaw, Ron M. Kagen, Dale A. Schwab
  • METHODS FOR DETECTING CYSTIC FIBROSIS MUTATIONS USING MITRA TIP EXTRACTION
    Publication number: 20230134138
    Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: October 31, 2022
    Publication date: May 4, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Nigel J. Clarke
  • EML4-ALK translocations in lung cancer
    Patent number: 11639529
    Abstract: The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are analyzed for the presence of one or more specific EML4-ALK fusion genes associated with neoplastic disorders.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: May 2, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • Methods for detecting lacosamide by mass spectrometry
    Patent number: 11624737
    Abstract: Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: April 11, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Beatrisa Boyadzhyan, Karin Thomassian, Anita Dermartirosian, Lou Jambor
  • METHODS FOR DETECTING DNA MUTATIONS USING MITRA TIP EXTRACTION
    Publication number: 20230078942
    Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: September 12, 2022
    Publication date: March 16, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Nigel J. Clarke
  • SYSTEM FOR DETERMINING AN UNDERLYING CAUSE OF ANEMIA
    Publication number: 20230083600
    Abstract: Disclosed herein are automated processes and systems for determining an underlying cause of anemia. Also disclosed herein are processes and systems for determining an underlying cause of microcytic anemia, normocytic anemia, and macrocytic anemia. Additionally disclosed herein are methods of treating the underlying cause of anemia in an individual in need thereof.
    Type: Application
    Filed: February 10, 2021
    Publication date: March 16, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Louis Michael Snyder, MD, Jeffrey Samuel Dlott