Patents Assigned to Quest Diagnostics
  • COMPOSITIONS AND METHODS FOR DETECTING CIRCULATING TUMOR DNA
    Publication number: 20230061928
    Abstract: The present technology provides polynucleotide compositions and methods of using the same to detect circulating tumor DNA (ctDNA) in a patient. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: August 15, 2022
    Publication date: March 2, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Suzzette Arnal, Taraneh Angeloni
  • CIRCULATING MICRORNA AS A MARKER FOR HEPATOCELLULAR CARCINOMA
    Publication number: 20230058588
    Abstract: Provided herein are methods for the diagnosis, or management of liver diseases, e.g.. hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.
    Type: Application
    Filed: August 22, 2022
    Publication date: February 23, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Kevin Qu, Ke Zhang, Maher Albitar
  • BCR-ABL TRUNCATION MUTATIONS
    Publication number: 20230058329
    Abstract: Truncation variants of BCR-ABL mRNA that produces BCR-ABL proteins with a truncated C-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cDNA constructs. Also provided are methods compositions and kits for detecting the BCR-ABL truncation variants. Also provided are methods for determining the prognosis of a patient diagnosed as having myeloproliferative disease, and methods for predicting the likelihood for resistance to a treatment with tyrosine kinase inhibitor in a patient diagnosed as having myeloproliferative disease. Additionally, methods for screening BCR-ABL tyrosine kinase domain inhibitors which rely on the recombinant cells are also disclosed.
    Type: Application
    Filed: May 27, 2022
    Publication date: February 23, 2023
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maher ALBITAR, Wanlong Ma
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 11579154
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: February 14, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Methods for detecting Norovirus
    Patent number: 11555223
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: January 17, 2023
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Mass spectrometric determination of non-derivatized, non-metabolized vitamin D
    Patent number: 11549954
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: January 10, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 11543415
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: January 3, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E Reitz
  • Detection of vitamins A and E by tandem mass spectrometry
    Patent number: 11513130
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: November 29, 2022
    Assignee: Quest Diagnostics Investment Incoporated
    Inventors: Sum Chan, Qibo Jiang
  • Bordetella detection assay
    Patent number: 11499199
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: November 15, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • AMYLOID BETA DETECTION BY MASS SPECTROMETRY
    Publication number: 20220349897
    Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Application
    Filed: June 13, 2022
    Publication date: November 3, 2022
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Diana Tran, Darren Weber, Nigel Clarke
  • Methylated markers for colorectal cancer
    Patent number: 11486007
    Abstract: Disclosed herein is a combination of genomic sequences whose methylation patterns have utility for the improved detection and differentiation between colorectal neoplasms. Further disclosed herein are methods, nucleic acids and kits for detecting or differentiating between colorectal neoplasms.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: November 1, 2022
    Assignees: Quest Diagnostics Investments Incorporated, CLINICAL GENOMICS PTY LTD
    Inventors: Susanne Pedersen, Lawrence LaPointe, Rohan Baker, Amber C. Donahue, Yen-lin Peng, Frederic Waldman
  • Methods for detecting cystic fibrosis mutations using mitra tip extraction
    Patent number: 11486005
    Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: November 1, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Nigel J. Clarke
  • Methods for quantitation of insulin levels by mass spectrometry
    Patent number: 11486874
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: November 1, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Steven W. Taylor, Michael McPhaul, Richard E. Reitz, Zhaohui Chen, Nigel Clarke
  • Methods for cell-free DNA extraction for non-invasive prenatal screening
    Patent number: 11485967
    Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non-invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 1, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Ben Anderson, Charles Strom, David Tsao, Yan Liu, Weimin Sun
  • Methods for detecting cystic fibrosis mutations using mitra tip extraction
    Patent number: 11473144
    Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: October 18, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Nigel J. Clarke
  • METHDOS FOR DETECTING ESTRADIOL BY MASS SPECTROMETRY
    Publication number: 20220326260
    Abstract: Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.
    Type: Application
    Filed: May 3, 2022
    Publication date: October 13, 2022
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Mildred M. GOLDMAN, Nigel J. CLARKE, Richard E. REITZ
  • Method to detect repeat sequence motifs in nucleic acid
    Patent number: 11466325
    Abstract: Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5?-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: October 11, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Feras Hantash, Weimin Sun, David C. Tsao, Dana Marie Root, Charles M Strom
  • APOLIPOPROTEIN E ISOTYPE DETECTION BY MASS SPECTROMETRY
    Publication number: 20220310375
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Application
    Filed: June 13, 2022
    Publication date: September 29, 2022
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Nigel Clarke
  • METHODS FOR DETECTING LACOSAMIDE BY MASS SPECTROMETRY
    Publication number: 20220308021
    Abstract: Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
    Type: Application
    Filed: June 13, 2022
    Publication date: September 29, 2022
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Beatrisa BOYADZHYAN, Karin Thomassian, Anita Dermartirosian, Lou Jambor
  • Quantitation of insulin-like growth factor-I and insulin-like growth factor-II with high-resolution mass spectrometry
    Patent number: 11454637
    Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: September 27, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard E. Reitz