Patents Assigned to Radiant Medical, Inc.
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Patent number: 7666215Abstract: Systems and methods for accurate temperature modification of a patient, or selected regions thereof, including inducing hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within a control unit. A temperature measurement scheme for obtaining body core temperature is provided, including methods of obtaining and analyzing temperature data to provide feedback to the control unit for use in controlling the heating and cooling of the heat exchange medium so as to heat or cool a patient to a desired target temperature.Type: GrantFiled: September 12, 2003Date of Patent: February 23, 2010Assignee: Radiant Medical, Inc.Inventors: Jeffrey Callister, Paul M. Stull, Andrew E. Wu, David J. Scott
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Patent number: 7658755Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.Type: GrantFiled: July 25, 2003Date of Patent: February 9, 2010Assignee: Radiant Medical, Inc.Inventors: Timothy R. Machold, Nicole Denise Bloom, Alex T. Roth, Dave J. Scott, Jose Alejandro, Edward A. Oliver
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Publication number: 20090043366Abstract: Apparatus, systems and methods for cooling or warming the temperature of all or a portion of the body of a human or animal subject to treat disorders including but not limited to sepsis, septic shock or other inflammatory or infectious conditions which can result in shock, hypoxia, ischemia and/or multiple organ failure in human or animal subjects.Type: ApplicationFiled: August 9, 2007Publication date: February 12, 2009Applicant: Radiant Medical, Inc.Inventor: Michael W. Dae
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Publication number: 20080228141Abstract: Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient.Type: ApplicationFiled: October 31, 2007Publication date: September 18, 2008Applicant: Radiant Medical Inc.Inventors: Robert Ginsburg, Timothy R. Machold, Michael T. Dineen, Arlene S. Ginsburg
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Patent number: 7407487Abstract: A temperature sensing system and method for determining a patient's core body temperature by measuring the temperature of the patient's blood at a location in a vessel lumen retrograde of an insertion point of a temperature sensor or sensors into the vessel lumen.Type: GrantFiled: March 14, 2005Date of Patent: August 5, 2008Assignee: Radiant Medical, Inc.Inventors: Michael W. Dae, Timothy R. Machold, Paul M. Stull
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Publication number: 20080114431Abstract: The present invention provides a method and apparatus for controlling the internal body temperature of a patient. According to the present invention, a catheter is inserted through an incision into a large blood vessel of a patient. By selectively heating or cooling a portion of the catheter lying within the blood vessel, heat may be transferred to or from blood flowing within the vessel and the patient's body temperature may thereby be increased or decreased as desired. The invention will find use in treating undesirable conditions of hypothermia and hyperthermia, or for inducing a condition of artificial hypothermia when desired. The method and system further provide for the cooling of initially hypothermic patients whose blood or body temperature has been warmed above the desired target level and the warming of initially hyperthermic patients whose blood or body temperature has been cooled below the desired target temperature.Type: ApplicationFiled: October 31, 2007Publication date: May 15, 2008Applicant: Radiant Medical, Inc.Inventor: Robert Ginsburg
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Publication number: 20080091253Abstract: A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.Type: ApplicationFiled: October 12, 2007Publication date: April 17, 2008Applicant: Radiant Medical Inc.Inventors: Amy Hammack, Jeff Callister, Paul Stull, Alex Roth, William Tremulis
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Patent number: 7311724Abstract: The present invention provides a method and apparatus for controlling the internal body temperature of a patient. According to the present invention, a catheter is inserted through an incision into a large blood vessel of a patient. By selectively heating or cooling a portion of the catheter lying within the blood vessel, heat may be transferred to or from blood flowing within the vessel and the patient's body temperature may thereby be increased or decreased as desired. The invention will find use in treating undesirable conditions of hypothermia and hyperthermia, or for inducing a condition of artificial hypothermia when desired.Type: GrantFiled: November 12, 2002Date of Patent: December 25, 2007Assignee: Radiant Medical, Inc.Inventor: Robert Ginsburg
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Publication number: 20070293919Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.Type: ApplicationFiled: July 23, 2007Publication date: December 20, 2007Applicant: RADIANT MEDICAL, INC.Inventors: Timothy Machold, Nicole Bloom, Alex Roth, Dave Scott, Jose Alejandro, Edward Oliver
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Publication number: 20070233212Abstract: Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient.Type: ApplicationFiled: March 13, 2007Publication date: October 4, 2007Applicant: Radiant Medical Inc.Inventors: Robert Ginsburg, Arlene Ginsburg, Timothy Machold, Michael Dineen
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Publication number: 20070213793Abstract: Methods for (a) preventing hypoxic damage to a potentially transplantable organ or tissue prior to explanation of that organ or tissue from the body of a mammalian transplant donor and (b) preventing rejection of a transplanted organ or tissue in a human or veterinary transplant recipient. The methods comprise placing a heat exchange apparatus in the vasculature of the donor or recipient and using that heat exchange apparatus to cool at least a portion of the body of the donor or recipient to a temperature below normothermia (e.g. below normothermia and sometimes between about 30° C. and about 36° C.).Type: ApplicationFiled: March 19, 2007Publication date: September 13, 2007Applicant: Radiant Medical, Inc.Inventor: Kenneth Hayes
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Publication number: 20070203552Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15? cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.Type: ApplicationFiled: February 12, 2007Publication date: August 30, 2007Applicant: RADIANT MEDICAL, INC.Inventors: TIMOTHY MACHOLD, WADE KELLER, ALEX ROTH, NICOLE BLOOM
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Patent number: 7258662Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.Type: GrantFiled: August 20, 2003Date of Patent: August 21, 2007Assignee: Radiant Medical, Inc.Inventors: Timothy R. Machold, Wade A. Keller, Alex T. Roth, Nicole Denise Bloom
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Publication number: 20070173735Abstract: An introducer sheath/temperature probe assembly that is insertable into a blood vesel of a human or veterinary patent to measure the temperature of blood flowing through that blood vessel. The introducer sheath/temperature probe assembly may be used in conjunction with an indwelling heat exchange catheter system to warm or cool all or a portion of the patient's body to a desired target temperature and to maintain such target temperature for a desired period of time.Type: ApplicationFiled: February 20, 2007Publication date: July 26, 2007Applicant: Radiant Medical, Inc.Inventors: Jeffrey Callister, Michael Dae, Amy Hammack
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Patent number: 7247165Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.Type: GrantFiled: May 9, 2005Date of Patent: July 24, 2007Assignee: Radiant Medical, Inc.Inventors: Timothy R. Machold, Nicole Denise Bloom, Alex T. Roth, Dave J. Scott, Jose Alejandro, Edward A. Oliver
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Patent number: 7238166Abstract: A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a mechanism for moving the heat exchange surface, thereby increasing heat exchange between the heat exchange surface and blood flowing past the heat exchange surface. Various methods of moving the heat exchange surface are disclosed.Type: GrantFiled: May 26, 2004Date of Patent: July 3, 2007Assignee: Radiant Medical, Inc.Inventor: Jeff Callister
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Patent number: 7217282Abstract: Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient.Type: GrantFiled: July 24, 2003Date of Patent: May 15, 2007Assignee: Radiant Medical, Inc.Inventors: Arlene S. Ginsburg, legal representative, Timothy R. Machold, Michael T. Dineen, Robert Ginsburg
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Patent number: 7186222Abstract: An introducer sheath/temperature probe assembly that is insertable into a blood vessel of a human or veterinary patent to measure the temperature of blood flowing through that blood vessel. The introducer sheath/temperature probe assembly may be used in conjunction with an indwelling heat exchange catheter system to warm or cool all or a portion of the patient's body to a desired target temperature and to maintain such target temperature for a desired period of time.Type: GrantFiled: September 10, 2002Date of Patent: March 6, 2007Assignee: Radiant Medical, Inc.Inventors: Jeffrey P. Callister, Michael W. Dae, Amy L. Hammack
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Publication number: 20070043409Abstract: Devices and methods for warming or cooling blood flowing through the vasculature of a human or animal subject so as to alter or control the temperature of all or part of the subject's body. Heat exchangers are positioned within the subject's vasculature and heated or cooled heat exchange fluid is circulated through the heat exchanger. For certain therapeutic applications, the heat exchanger and associated elements of the system have sufficient power to lower the subject's body temperature by at least 3 degrees C. in less than 30 minutes.Type: ApplicationFiled: June 29, 2006Publication date: February 22, 2007Applicant: Radiant Medical, Inc.Inventors: Ben Brian, Scott Wilson
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Publication number: 20070038277Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.Type: ApplicationFiled: August 8, 2006Publication date: February 15, 2007Applicant: Radiant Medical, Inc.Inventors: Michael Dae, Timothy Machold, Wade Keller