Patents Assigned to Radiometer Medical A/S
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Patent number: 7195697Abstract: A membrane for a sensor, a method for the preparation thereof, a layered membrane structure and a sensor for analytical measurements which require controlled analyte permeability. The membrane, layered structure and sensor may be used for biological, physiological and chemical measurements, however, are especially applicable for electrochemical measurements of glucose, lactate, urea and creatinine. The membrane comprises at least one polymer material, at least one surfactant, and at least one hydrophilic compound in admixture to provide a membrane structure in which micelles of hydrophilic compound lined with thin layers of surfactant are randomly distributed in the bulk polymer of the membrane. Upon conditioning of the membrane a structure of a perculating network of pores lined with surfactant is formed which has excellent permeability properties. The membrane has the additional advantage of a proper adhesion to polymer encapsulant structures.Type: GrantFiled: November 21, 2002Date of Patent: March 27, 2007Assignee: Radiometer Medical A/SInventor: Lydia Clausen
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Patent number: 6980285Abstract: The present invention relates to a method in quality control of a spectrophotometer, comprising the steps of determining with the spectrophotomer a spectrum Am(?) of a fluid QC sample containing a dye, and determining a wavelength shift ?? from C??(?), Am(?), in which C??(?) is a predetermined coefficient vector previously stored in a memory of the spectrophotometer.Type: GrantFiled: June 10, 1999Date of Patent: December 27, 2005Assignee: Radiometer Medical A/SInventor: Heine Hansen
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Patent number: 6943883Abstract: An apparatus, a sample cuvette and a method for optical measurements on samples which show variable levels of scattering are provided. The apparatus, sample cuvette and method may be used for optical measurements on biological, physiological and chemical samples, however, are especially applicable for optical measurements on whole blood.Type: GrantFiled: July 18, 2002Date of Patent: September 13, 2005Assignee: Radiometer Medical A/SInventor: Henrik Fodgaard
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Patent number: 6880384Abstract: A blood analyzer has a control system controlling the operation of the analyzer, a sensor measuring a parameter of a blood sample, exposure means exposing the sensor to the blood sample, reporting means reporting the parameter of the blood sample, and a sample handler. The sample handler comprises a sampler bed receiving a blood sampler which contains the blood sample and a stirring element. The sample handler further comprises moving means moving the stirring element in the blood sampler when the sampler is arranged in the sampler bed. The blood analyzer is capable of handling and analyzing blood samples. A blood sample handler is provided as well, as are methods for handling and analyzing of a blood sample. The moving means moving the stirring element is preferably a magnet and the stirring element is magnetic.Type: GrantFiled: December 23, 2002Date of Patent: April 19, 2005Assignee: Radiometer Medical A/SInventors: Kristian Jacob Hvidtfeldt, Flemming Aas, Caspar Buchholtz Frederiksen, Erik Kjølbye Hansen
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Patent number: 6805781Abstract: The invention concerns an electrode device comprising an ion selective material, a solid state, inner reference system of sodium vanadium bronze and a contact material, where sodium may be reversibly intercalated, in the bronze. Such an electrode device may for instance be sensitive to ions, such as H+, Na+, K+and Ca2+. It may also include a reactive material in which a particular analyte is reacted to form an ion product, to which the ion selective material is sensitive, such as in electrode devices of the Severinghaus-type or in biosensors. The electrode device according to the invention can be prepared by thick film printing.Type: GrantFiled: August 29, 2002Date of Patent: October 19, 2004Assignee: Radiometer Medical A/SInventors: Poul Ravn Sørensen, Birgit Zachau-Christiansen
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Patent number: 6723216Abstract: A method for detection of a bubble in a liquid which is placed in a measuring chamber and is in contact with a sensor for measuring the partial pressure of a particular gas in a liquid is provided. The method includes performing a first measurement of the partial pressure of the particular gas in the liquid at a first pressure in the measuring chamber. Next, the pressure in the measuring chamber is changed to a second pressure. A second measurement of the partial pressure of the gas in the liquid at the second pressure in the measuring chamber is performed. An expected result of the second measurement based on the first measurement and assuming that no bubbles are present in the measuring chamber during any of the measurements is provided. The actual result of the second measurement is compared with the expected result and a conclusion is drawn on the presence of a gas bubble in the liquid based on the comparison. An apparatus for measuring the content of a particular gas in a liquid is also provided.Type: GrantFiled: April 29, 2002Date of Patent: April 20, 2004Assignee: Radiometer Medical A/SInventors: Michael Taagaard, Allan Larsen
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Patent number: 6689318Abstract: The apparatus for analysis of physiological fluids of the invention contains equipment for automatic introduction of reference fluids to a sample aggregate inlet of the apparatus. The apparatus also contains equipment for analyzing the samples.Type: GrantFiled: February 24, 1997Date of Patent: February 10, 2004Assignee: Radiometer Medical A/SInventors: Allan Spork, Bent Pedersen, Niels Fremming, Kristian Jacob Hvidtfeldt
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Publication number: 20030236497Abstract: A sampler cap includes a sampler connector, an analyzer connector and a liquid impermeable closure member, which may be a membrane or a filter. The sampler cap may be used to transfer a test sample to an analyzer without removing the sampler cap from the sampler.Type: ApplicationFiled: June 20, 2003Publication date: December 25, 2003Applicant: Radiometer Medical A/SInventors: Niels Fremming, Jorgen Andersen
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Patent number: 6605471Abstract: The present invention relates to a method for determining at least one parameter of samples of physiological liquids, to test devices which may be used in the method, to a holder comprising a plurality of such test devices, and to a measuring apparatus adapted to accommodate the holder and to be used in the method and to a system comprising the apparatus and the holder.Type: GrantFiled: April 21, 1999Date of Patent: August 12, 2003Assignee: Radiometer Medical A/SInventors: Finn C. Lundsgaard, Henrik Kagenow, Willy Andersen, Peter Aage Frischauf
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Patent number: 6551480Abstract: The reference electrode comprises an electrode plug and a chamber (16) closed at the rear containing an electrolyte. The chamber (16) has an aperture (23) covered by a membrane (26) of a material permitting diffusion of ions therethrough, but whose surface is closed for proteins and similar macromolecular substances. A diffusion tight diaphragm element (27) having a through-going orifice (30) located radially within the aperture is situated on the outer side of the ion diffusion membrane (26) relative to the chamber, and the orifice (30) is smaller than the aperture (23).Type: GrantFiled: February 8, 2001Date of Patent: April 22, 2003Assignee: Radiometer Medical A/SInventors: Michael Taagaard, Flemming Aas
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Patent number: 6183445Abstract: The present invention is directed to a syringe with a retractable needle guard. The syringe has two coaxial tubular bodies, an inner and an outer body, which are adapted to telescope in relationship to each other. The outer tubular body is adapted to at least partially receive the body of the container from which fluid is to be drawn and the inner tubular body is adapted to be displaced from a retracted position to an advanced position. In the retracted position the needle is exposed, while in the advanced position the needle is surrounded by the inner tubular body. The syringe with a retractable needle guard may also be adapted to connect the outer tubular body with the needle without connecting it to the container from which fluid is to be drawn.Type: GrantFiled: September 17, 1997Date of Patent: February 6, 2001Assignee: Radiometer Medical A/SInventors: Per William Lund, Knud Robert Petersen
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Patent number: 6099804Abstract: In a sensor for measuring an analyte in a biological sample whose measuring surface is covered by or comprises a membrane, the membrane has free groups on the surface facing the sample. The surface is modified such that a hydrophilic component is immobilized on the surface in such a manner that chains of the hydrophilic component are chemically bonded to free groups on the surface. Thus, the surface is provided with a more hydrophilic character relative to its unmodified state.Type: GrantFiled: October 6, 1997Date of Patent: August 8, 2000Assignee: Radiometer Medical A/SInventors: Lydia Dahl Clausen, Allan Milton Byrnard, Jesper Svenning Kristensen
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Patent number: 6051389Abstract: The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte in a test fluid. The sensor has at least one enzyme layer comprising an immobilized enzyme for which the analyte is a substrate. The immobilized enzyme is obtained by formation of one or more covalent link(s), optionally by using a cross-linking agent, between the enzyme and at least one type of macromolecule in the presence of a competitive inhibitor for said enzyme. The present invention also relates to a membrane for an enzyme sensor. Furthermore, the invention relates to a method for stabilizing the enzymatic activity of an enzyme sensor.Type: GrantFiled: August 12, 1999Date of Patent: April 18, 2000Assignee: Radiometer Medical A/SInventors: Thomas Ahl, Allan Milton Byrnard
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Patent number: 5883235Abstract: Calix?4!arene compounds are disclosed that can be used as active components in a calcium sensitive sensor. The compounds exhibit strong calcium ion binding selectivity over sodium and potassium ions and they are stable during sterilization.Type: GrantFiled: October 14, 1997Date of Patent: March 16, 1999Assignee: Radiometer Medical A/SInventors: Allan Milton Byrnard, Rocco Ungaro, Andrea Pochini
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Patent number: 5705620Abstract: A calix?4!arene compound, application of the compound as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The sensor is not very sensitive to sodium and potassium ions.Type: GrantFiled: April 8, 1996Date of Patent: January 6, 1998Assignee: Radiometer Medical A/SInventors: Allan Milton Byrnard, Rocco Ungaro, Andrea Pochini
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Patent number: 5525518Abstract: A method of photometric in vitro determination of at least one blood gas parameter in a sample of whole blood. The whole blood sample is obtained by connecting an at least partially transparent sample container to an in vivo locality and transferring whole blood into the sample container, then breaking the connection. The sample container is arranged in an optical system which has a radiation source and a means for detecting radiation to locate the sample container between the radiation source and the radiation detection means. Radiation is transmitted to the sample from the radiation source and radiation emitted from the sample is transmitted to the radiation detection means. The detected radiation is used to determine the blood gas parameter of the sample. A system for use in this method has a radiation source, a radiation detection means, an at least partially transparent sample container, and a sample container station.Type: GrantFiled: June 21, 1991Date of Patent: June 11, 1996Assignee: Radiometer Medical A/SInventors: Finn C. Lundsgaard, Niels-Henrik Jensen, Willy Andersen