Abstract: The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.
August 23, 2011
Date of Patent:
December 9, 2014
Ramamohan Rao Davuluri
Ramamohan Rao Davuluri, Ravi Ponnaiah, Guruswamy Batthni, Chandra Murthy V. R. Medida, Santhosh Dummu