Patents by Assignee Ramot at Tel-Aviv University, Ltd.
  • Patent number: 9757448
    Abstract: Methods for treating and reducing risk of cerebral amyloid angiopathy (CAA) using nasal vaccination with a proteosome adjuvant.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: September 12, 2017
    Assignees: The Brigham and Women's Hospital, Inc., Ramot At Tel Aviv University Ltd.
    Inventors: Howard Weiner, Dan Frenkel, Veronica Lifshitz
  • Patent number: 9750817
    Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: September 5, 2017
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Itai Benhar, Nir Osherov, Vladimir Dergachev, Alex Martin Szpilman
  • Patent number: 9730998
    Abstract: The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection by (TiLV). The invention also relates to methods for using the vaccines to protect tilapines from TiLV-induced disease.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: August 15, 2017
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Kimron Veterinary Institute, Ramot at Tel-Aviv University Ltd.
    Inventors: Eran Bacharach, Avi Eldar
  • Patent number: 9734638
    Abstract: A method of obtaining a three-dimensional digital model of an artificial object, made up of a plurality of geometric primitives, the artificial object being in a single two-dimensional photograph, the method comprising: using edge detection to define a two-dimensional outline of the artificial object within the photograph; interactively allowing a user to define two-dimensional profiles of successive ones of the geometric primitives; interactively allowing a user to sweep respective profiles over an extent of a corresponding one of the geometric primitives within the image; generating successive three-dimensional model parts from existing detected edges of the corresponding geometric primitives and the sweeping of the respective profile; and aligning the plurality of three-dimensional model parts to form the three-dimensional model.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: August 15, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Daniel Cohen-Or, Ariel Shamir, Tao Chen
  • Patent number: 9717761
    Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: August 1, 2017
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Sandu Pitaru, Javier Ganz, Daniel Offen, Eldad Melamed
  • Patent number: 9717772
    Abstract: Methods for the prevention and treatment of ocular disorders, in particular glaucoma, through blocking the toxic effects of ?-amyloid (A?) derivatives, pharmaceutical compositions for effecting such prevention and interval treatment thereof.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: August 1, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Hermann Russ, Wojciech Danysz, Christopher Graham Raphael Parsons
  • Patent number: 9718859
    Abstract: Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are converted to inhibitors of GSK-3 upon interacting with the enzyme's catalytic site and hence act as disease-selective inhibitors for treating conditions associated with increased activity and/or expression of GSK-3. Each of the disclosed peptides is independently of no more than 15 amino acid residues, and has an amino acid sequence which comprises a ZX1X2X3Z(p) recognition motif of GSK-3, wherein Z(p) is a phosphorylated serine or threonine residue; Z is a phosphorylatable serine or threonine residue, and each of X1, X2 and X3 is independently any amino acid, as defined in the specification. Further disclosed are methods of identifying a putative substrate-competitive peptide inhibitor of GSK-3 which are effected by computational modeling and screening.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: August 1, 2017
    Assignees: Ramot at Tel-Aviv University Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Hagit Eldar-Finkelman, Miriam Eisenstein, Avital Licht-Murava
  • Patent number: 9718538
    Abstract: A fluidic system is disclosed. The system comprises a plurality of fluidic oscillatory actuators, and at least one synchronization conduit connecting two or more of the actuators such as to effect synchronization between oscillations in the two or more connected actuators.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: August 1, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Avraham Seifert, Isaac Dayan, Tom Shtendel
  • Publication number: 20170209845
    Abstract: A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud GAZIT, Meital RECHES
  • Publication number: 20170198021
    Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.
    Type: Application
    Filed: March 16, 2017
    Publication date: July 13, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yaron BRAM, Ehud GAZIT
  • Publication number: 20170182176
    Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
    Type: Application
    Filed: March 2, 2017
    Publication date: June 29, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit SATCHI-FAINARO, Ela MARKOVSKY, Hemda BAABUR-COHEN
  • Patent number: 9687562
    Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: June 27, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit Satchi-Fainaro, Ela Markovsky, Hemda Baabur-Cohen
  • Patent number: 9688719
    Abstract: Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive inhibitors and have an amino acid sequence designed so as to bind to a defined binding site subunit in GSK-3.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 27, 2017
    Assignees: Ramot at Tel-Aviv University Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Hagit Eldar-Finkelman, Miriam Eisenstein
  • Publication number: 20170174791
    Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain. Methods of generating same and uses thereof are also provided.
    Type: Application
    Filed: March 2, 2017
    Publication date: June 22, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Itai BENHAR, Lilach VAKS
  • Patent number: 9682098
    Abstract: The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: June 20, 2017
    Assignees: Ramot at Tel-Aviv University Ltd., Freie Universitaet Berlin
    Inventors: Rainer Haag, Wiebke Fischer, Abdul Mohiuddin Quadir, Ronit Satchi-Fainaro, Paula Ofek
  • Patent number: 9675567
    Abstract: Compounds of formula (I): and pharmacologically acceptable salts and pro-drugs thereof, wherein the variables are as defined in the specification, are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 13, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Simon Edwards, Ruth Meriel Kimberley, Richard Edward Armer, Mohammed Nawaz Khan
  • Publication number: 20170146706
    Abstract: An optical element is disclosed. The optical element comprises: a first phase shift mask formed on a first optical material and constituted to generate a positive phase shift, and a second phase shift mask formed on a second optical material and constituted to generate a negative phase shift, wherein the phase shift masks are arranged serially on an optical axis, and wherein a refractive index of at least one of the first and second optical materials varies with the temperature at a rate of at least 50×10?6 per degree Kelvin.
    Type: Application
    Filed: February 8, 2017
    Publication date: May 25, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Shay ELMALEM, Emanuel MAROM, Harel HAIM, Naim KONFORTI
  • Publication number: 20170146452
    Abstract: Apparatus and method for efficiently assessing the results of reflectance spectroscopy on a soil sample to determine the presence of contaminants in the soil, by constructing a model based on analysis of known samples. The model may be constructed using an all possibilities approach and data mining techniques, on a range of samples, for example of different kinds of soil without pollutants and with different levels of pollutants. The Disclosure relates both to the construction of the model and to its use in the field in analyzing soil contaminants.
    Type: Application
    Filed: February 5, 2017
    Publication date: May 25, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Eyal BEN-DOR, Gil ESHEL, Guy SCHWARTZ
  • Patent number: 9655933
    Abstract: The invention relates to a filamentous bacteriophage, carrying bacterial Lipopolysaccharide (LPS) endotoxin on its surface, for use in treating cancer and in inhibiting angiogenesis, and in a different context, for use in promoting angiogenesis in diseases or conditions in which there is insufficient angiogenesis.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 23, 2017
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Beka Solomon, Eyal Dor-On
  • Publication number: 20170138952
    Abstract: A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation.
    Type: Application
    Filed: January 31, 2017
    Publication date: May 18, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ady ARIE, Amos DANIELLI