Patents Assigned to Regents of the University of Minnesota, a Minnesota corporation
  • Publication number: 20040170609
    Abstract: The present invention provides a novel isolated and purified fungus Hirsutella minnesotensis. The present invention also provides a pesticidal composition of an effective amount of an isolated and purified fungal strain of Hirsutella rhossiliensis or Hirsutella minnesotensis that is capable of controlling nematode infestation and a carrier. Further, the present invention provides methods of controlling nematode infestation.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 2, 2004
    Applicant: Regents of the University of Minnesota, a Minnesota corporation
    Inventor: Senyu Chen
  • Publication number: 20030229907
    Abstract: Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage. In mice, an age-related CNS disorder characterized by agitation, neophobia, seizures, inactivity, diminished cerebral glucose utilization, cortico-limbic gliosis, and death, develops. An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins (APP) produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression. In transgenic mice the disorder develops in direct relationship to brain levels of transgenic APP, but mutant APP confers the phenotype at lower levels of expression than wild-type APP. The disorder occurs in the absence of extracellular amyloid deposition, indicating that some pathogenic activities of APP are dissociated from amyloid formation.
    Type: Application
    Filed: October 15, 2002
    Publication date: December 11, 2003
    Applicants: John Hopkins University, a Maryland corporation, Regents of the University of Minnesota, a Minnesota corporation
    Inventors: Karen Hsiao, David R. Borchelt, Sangram S. Sisodia
  • Publication number: 20030045610
    Abstract: Biopolymers and biopolymer blends, including block copolymers, prepared via enzyme-mediated catalysis preferably in a microorganism host in which the reaction conditions are selected to produce biopolymers and biopolymer blends having particular chemical compositions and microstructures.
    Type: Application
    Filed: August 12, 2002
    Publication date: March 6, 2003
    Applicant: Regents of the University of Minnesota, a Minnesota Corporation
    Inventors: Friedrich Srienc, Aaron S. Kelley, Nikolaos Mantzaris
  • Publication number: 20010018414
    Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: March 12, 2001
    Publication date: August 30, 2001
    Applicant: Regents of the University of Minnesota, a Minnesota corporation
    Inventor: Gary L. Nelsestuen