Patents Assigned to Regents of the University of Minnesota
  • Patent number: 10933042
    Abstract: An intravenous baclofen solution is disclosed, along with methods of dosing and treatment therewith.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: March 2, 2021
    Assignees: Allaysis, LLC, Regents of the University of Minnesota
    Inventors: James C. Cloyd, Adolfo L. Gomez, Linda Krach, Robert L. Kriel, John Schrogie, Stephen John Tucker, Rob Tuohy
  • Patent number: 10925851
    Abstract: The invention provides methods and compositions for producing analgesia in an animal.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: February 23, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Robert Vince, Rohit Singh, Swati Sudhakar More
  • Patent number: 10919030
    Abstract: Forming a diene includes contacting a reactant including at least one of a cyclic ether and a diol with a heterogeneous acid catalyst to yield a reaction mixture including a diene. The heterogeneous acid catalyst includes at least one of a Lewis acid catalyst, a supported Lewis-acid catalyst, a Brnsted acid catalyst, a solid acid catalyst, a supported phosphoric acid catalyst, and a sulfonated catalyst. The dehydration of cyclic ethers and diols with high selectivity to yield dienes completes pathways for the production of dienes, such as isoprene and butadiene, from biomass in high yields, thereby promoting economical production of dienes from renewable resources.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 16, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Omar A. Abdelrahman, Charles S. Spanjers, Dae Sung Park, Michael Tsapatsis, Limin Ren, Paul J. Dauenhauer
  • Patent number: 10918099
    Abstract: The present disclosure provides for a composition and method for attracting bed bugs to a trap or to a location where an insecticide or pesticide is present, or to a trap or a location where a bed bug infestation can be detected. The present disclosure provides for a composition for attracting bed bugs that includes one or more of methyl diethanolamine (MDEA), monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), and dimethyl trisulfide (DMTS); a carrier; and optionally one or more amides selected from oleamide, octanamide, nonanamide, and laurylamide; urea, biuret, or triuret; and one or more aliphatic fatty acids. The present disclosure further provides for a method for treating an article by applying the composition to the article, where the article comprises a device for trapping or detecting bed bugs or a device for treating a bed bug infestation.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: February 16, 2021
    Assignees: Ecolab USA Inc., Regents of the University of Minnesota
    Inventors: Joelle F. Olson, Stephen A. Kells, Leonard M. Ver Vers, Roger D. Moon, Yvonne M. Killeen
  • Publication number: 20210040148
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Application
    Filed: October 22, 2020
    Publication date: February 11, 2021
    Applicants: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Publication number: 20210041938
    Abstract: A method includes generating gate-level activity information of a processor design for all possible executions of a target application for any possible inputs to the target application. The method includes performing a constrained timing analysis on the processor design based on the gate-level activity information to determine a minimum operating voltage for executing the target application on the processor.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Applicants: Regents of the University of Minnesota, University of Illinois at Urbana-Champaign
    Inventors: Hari Cherupalli, Rakesh Kumar, John Sartori
  • Patent number: 10914566
    Abstract: A position sensing system for measuring a position of a moving object includes an electromagnet configured to generate an alternating magnetic field, and a magnetic sensor configured to measure an intensity of a first magnetic field that is based on the alternating magnetic field. A controller is configured to estimate a position of the moving object based on the measured intensity of the first magnetic field.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: February 9, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Ryan Madson, Rajesh Rajamani
  • Patent number: 10912797
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 9, 2021
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Patent number: 10912941
    Abstract: Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: February 9, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Shalom Michaeli, John T. Vaughan, Silvia Mangia, Lauri Lehto, Matthew Johnson, Julia Slopsema, Olli Gröhn, Gregory F. Molnar
  • Publication number: 20210031143
    Abstract: A fluid power circuit with a switch-mode power transformer used to transfer power while keeping the pressure of power source and reverse osmosis processes relatively decoupled. The switch-mode power transformer uses the inertia of a hydraulic motor driven electric generator and switching of a hydraulic motor inlet between high and low-pressure ends to decrease the pressure at which power is being transmitted to a reverse osmosis process.
    Type: Application
    Filed: June 30, 2020
    Publication date: February 4, 2021
    Applicant: Regents of the University of Minnesota
    Inventors: Jeremy W. Simmons, II, James D. Van de Ven
  • Patent number: 10905113
    Abstract: This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 ?m to 500 ?m.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: February 2, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Alptekin Aksan, Morwena Jane V. Solivio, Marcus Kramer, Rebekah Less
  • Patent number: 10907212
    Abstract: Nectin-4 and Nectin-1 in cancer progression/development and as a therapeutic target for cancer.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: February 2, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Amy P. Skubitz, Kristin L. M. Boylan, Petra Buchanan, Rory Manion
  • Patent number: 10907181
    Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: February 2, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Kechun Zhang, Mingyong Xiong
  • Patent number: 10907971
    Abstract: A vision-aided inertial navigation system comprises an image source to produce image data for poses of reference frames along a trajectory, a motion sensor configured to provide motion data of the reference frames, and a hardware-based processor configured to compute estimates for a position and orientation of the reference frames for the poses. The processor executes a square-root inverse Schmidt-Kalman Filter (SR-ISF)-based estimator to compute, for features observed from poses along the trajectory, constraints that geometrically relate the poses from which the respective feature was observed. The estimator determines, in accordance with the motion data and the computed constraints, state estimates for position and orientation of reference frames for poses along the trajectory and computes positions of the features that were each observed within the environment.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: February 2, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Stergios I. Roumeliotis, Kejian J. Wu, Tong Ke
  • Patent number: 10898912
    Abstract: A nozzle assembly including an inner tube and an outer housing. The inner tube terminates at an outlet end and defines a first flow passage. The first flow passage directs first fluid flow to the outlet end in a primary flow direction. The outer housing includes a tubular side wall and an end wall. The tubular side wall defines a central axis. The end wall defines an exit orifice and an interior guide structure. The outlet end is axially aligned with the exit orifice. A second flow passage is established between the inner tube and the outer housing. The interior guide structure is configured and arranged relative to the outlet end to direct at least a portion of a second fluid flow from the second flow passage toward the outlet end in a direction initially opposite the primary flow direction for generating mixed fluid flow.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 26, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Alison Hoxie, Paul John Strykowski, Vinod Srinivasan
  • Patent number: 10904676
    Abstract: A hearing system to activate an auditory system using cerebrospinal fluids includes at least one processor configured to receive an audio signal captured using a sound sensor (e.g., a microphone), extract temporal and spectral features from the audio signal, and create modulated ultrasound signals in a range of 20 Hz to 20 kHz with ultrasound carrier frequencies in the range of 50 kHz to 4 MHz, which are ultrasound frequencies that are well-suited to reach the cerebrospinal fluids (e.g., can pass across the skull/bones to reach the cerebrospinal fluids). The system further includes at least one ultrasonic transducer which receives the modulated signal and delivers the modulated signal to the body and activates the auditory system via vibration of cerebrospinal fluids that vibrate cochlear fluids, bypassing the normal conductive pathway that uses middle ear bones and minimizing bone conduction and distortion through the skull.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: January 26, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Hubert H. Lim, Mark Hamilton, Hongsun Guo, Cory Gloeckner
  • Patent number: 10899793
    Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(?O)—W—X—Y—Z—N(R2)2??(I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: January 26, 2021
    Assignees: Regents of the University of Minnesota, Torrey Pines Institute for Molecular Studies
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Jon R. Appel, Marc A. Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh G. Santos
  • Patent number: 10901053
    Abstract: Systems and method for measuring and mitigating radio frequency (“RF”) induced currents on electrical leads, electrodes, and other electrically conductive objects present in the bore of a magnetic resonance imaging (“MRI”) scanner when the MRI scanner is operated to image an object or subject are described. The methods described in the present disclosure can be implemented as a pre-scan procedure to obtain images from which the current induced on the electrical lead can be estimated. This information can then be used to adjust the RF excitation used in a subsequent pulse sequence to mitigate induced currents and reduce heating in the lead. As such, the methods described in the present disclosure provide for improved patient safety.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: January 26, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Yigitcan Eryaman, Gregor Adriany, Noam Harel, Gregory F. Molnar
  • Patent number: 10897880
    Abstract: Described herein is a method for producing a chimeric non-human animal expressing a human NKX2-5, HANDII, TBX5 gene or a combination thereof gene comprising: a) generating a NKX2-5, HANDII, TBX5 or combination thereof null non-human animal cell, wherein both copies of the non-human NKX2-5, HANDII, TBX5 gene or combination thereof carry a mutation that prevents production of functional NKX2-5, HANDII, TBX5 protein or combination thereof in said non-human animal; b) creating a NKX2-5, HANDII, TBX5 or combination thereof null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said NKX2-5, HANDII, TBX5 or combination thereof null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an NKX2-5, HANDII, TBX5 or combination thereof null non-human blastocyst; c) introducing human stem cells into the NKX2-5, HANDII, TBX5 or combination null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudo
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 26, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Daniel J. Garry, Mary G. Garry, Naoko Koyano
  • Patent number: 10894061
    Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 19, 2021
    Assignees: Regents of the University of Minnesota, The University of North Carolina at Chapel Hill, St. Jude Children's Research Hospital, Inc.
    Inventors: Bruce R. Blazar, Brent Koehn, Peter J. Murray, Jenny P. Y. Ting, Robert Zeiser, Jeff S. Miller