Patents Assigned to Regents of the University of Minnesota
  • Patent number: 11257214
    Abstract: Systems and methods are described for segmenting a medical image using a two-stage variational method in which fracture mechanics are used in the second stage to remove fine-scale contact bridges that connect object contours generated in the first stage. The image segmentation can be used to segment objects, such as bone objects, from surrounding tissues in a medical image, such as an image obtained with a computed tomography (“CT”) or other x-ray imaging system.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: February 22, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Dominik Schillinger, Tarun Gangwar, Takashi Takahashi, Jeff Calder
  • Patent number: 11258300
    Abstract: A management device includes at least one processor communicatively coupled to at least one energy resource controller controlling at least one energy resource and to at least one deferrable load controller controlling power to at least one deferrable load. The is configured to receive an indication, determined based on a frequency value of an electrical network and a nominal frequency value, that a frequency anomaly event has occurred. Responsive to receiving the indication that the frequency anomaly event has occurred, the processor is also configured to determine, for at least one of the energy resource and the deferrable load, based on the frequency value, the nominal frequency value, and a power value of the electrical network, a respective power command, and cause at least one of the at least one energy resource and the at least one deferrable load to modify operation based on the respective power command.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: February 22, 2022
    Assignees: Alliance for Sustainable Energy, LLC, Regents of the University of Minnesota
    Inventors: Blake Richard Lundstrom, Sourav Kumar Patel, Murti Salapaka
  • Patent number: 11254898
    Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
    Type: Grant
    Filed: January 26, 2019
    Date of Patent: February 22, 2022
    Assignees: Toyota Motor Corporation, Regents of the University of Minnesota
    Inventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
  • Patent number: 11241171
    Abstract: Embodiments relate to devices, systems and methods for monitoring neuromuscular blockage. In an embodiment, a neuromuscular blockage monitoring system comprises a patch device comprising a unitary patch body, at least two electrodes and at least one sensor, the at least one sensor arranged between the at least two electrodes on the unitary patch body; and a stimulator device operatively coupled to the patch device and configured to provide at least one electrical signal to the at least two electrodes to stimulate a muscle motor point and to receive a signal from the at least one sensor related to a result of the stimulation of the muscle motor point.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: February 8, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: William Keith Durfee, Paul Anthony Iaizzo, Jesus Arturo Cabrera, Jenna Christine Iaizzo, John Mehawej, Kevin Ruda, Jason Paul McConnell
  • Patent number: 11236360
    Abstract: Methods to prepare recombinant adeno-associated virus (AAV) capsids with altered tropism and compositions having AAVs with altered tropism are provided.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: February 1, 2022
    Assignee: Regents of the University of Minnesota
    Inventor: Daniel Schmidt
  • Patent number: 11236057
    Abstract: Disclosed are compounds of the Formula 1 wherein A is an aromatic moiety; H is a hydrophobic group comprising a main alkyl chain having from about 3 to about 26 carbon atoms and comprising a C2 or greater alkyl chain branched from the main alkyl chain; and K is a hydrophilic group.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: February 1, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Christoph Krumm, Kristeen Joseph, Dae Sung Park, Mahesh Mahanthappa, Paul J. Dauenhauer
  • Patent number: 11234418
    Abstract: Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: February 1, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bernhard J. Hering, Christopher Burlak
  • Publication number: 20220023267
    Abstract: The invention provides compositions and methods for treating conditions associated with decreased activity of hydrogen sulfide.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 27, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Robert Vince, Swati Sudhakar More
  • Publication number: 20220026356
    Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 27, 2022
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Robert Vince, Swati Sudhakar More
  • Patent number: 11231475
    Abstract: A fully sampled calibration data set, which may be Cartesian k-space data, is used to obtain targeted and optimal interpolation kernels for non-regularly sampled data. The calibration data are self-calibration data obtained from a time-averaged image, or re-sampled data. ACS data are resampled for calibration of region-specific kernels. Subsequently, an explicit noise-based regularized solution can be utilized to estimate region-specific kernels for reconstruction.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: January 25, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Steen Moeller, Mehmet Akcakaya, Seng-Wei Chieh
  • Patent number: 11231476
    Abstract: Accelerated data acquisition using two-dimensional (“2D”) radio frequency (“RF”) pulse segments as virtual receivers for a parallel image reconstruction technique, such as GRAPPA, is provided. Data acquisition is accelerated using segmented RF pulses for excitation, refocusing, or both, and undersampling k-space along a dimension of the RF pulse segments. In this way, parallel image reconstruction techniques, such as GRAPPA, can be adapted to work with a single RF receive coil. By undersampling the data acquisition and finding correlations between the data from different segments, unsampled data can be recovered. This shortens scan times, yielding the advantages of segmented pulses without the formerly required long scans.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: January 25, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Michael Garwood, Michael Mullen, Alexander Gutierrez, Jarvis Haupt
  • Patent number: 11224237
    Abstract: Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: January 18, 2022
    Assignees: Covercress Inc., Board of Trustees of Illinois State University, Regents of the University of Minnesota
    Inventors: Tim Ulmasov, Cristine Handel, Gary Hartnell, John C. Sedbrook, Michael David Marks, Ratan Chopra, Maliheh Esfahanian
  • Publication number: 20220008852
    Abstract: Aspects of the disclosure provide methods of making a coated filtration material. Various methods include providing a base filter material and applying a first coating to the base filter material, the first coating being in nanoparticle form. A second coating is applied on top of the first coating, the second coating being a nanoscale inorganic material. The method further includes removing the first coating in such a way that the second coating remains on the base filter material. Methods of the disclosure can be used to manufacture coated filtration materials having a coating with a porosity of 90% or greater and a pore size in the range of 0.1-0.5 ?m.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 13, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: David You-Hong Pui, Qisheng Ou
  • Patent number: 11221384
    Abstract: The present disclosure provides a method for producing a radio frequency (RF) pulse for use in magnetic resonance. The steps of the method include providing a computer system and a set of RF input parameters. The computer system then generates an optimal phase surface by iteratively updating an initial RF pulse profile based at least in part on the set of RF input parameters. The optimal phase surface contains a set of iteratively generated RF pulse profiles with various characteristics, such as bandwidths or selectivity. The steps of the method further include selecting an RF pulse profile with the computer system based on a search on the optimal phase surface, which can be implemented with the help of an index file. The search can be performed using an artificial intelligence algorithm, and can retrieve the shortest pulse profile that satisfies user input parameters or requirements.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 11, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Gianluigi Veglia, Manu Veliparambil Subrahmanian
  • Patent number: 11219751
    Abstract: Embodiments relate to a system for providing a first fluid and a second fluid. The system includes a catheter hub, a flexible cover, and a catheter. The flexible cover is configured to attach to the catheter hub and provide a seal therewith. The catheter is configured to be at least partially arranged within the catheter hub and the flexible cover and pass through the seal. The catheter includes a primary lumen and a secondary lumen, wherein the primary lumen is configured to provide the first fluid at a distal end of the catheter, and the secondary lumen is configured to provide the second fluid at each of a plurality of apertures arranged on an outer radial wall of the catheter.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: January 11, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bharathi Dasan Jagadeesan, Sean Lester Moen
  • Publication number: 20220001006
    Abstract: The present disclosure provides virus like nanoparticles (VLPs), which are capable of displaying multiple copies of a SARS-CoV-2 antigen, for eliciting protective immunity against a SARS-CoV-2 infection, as well as polypeptides, compositions and methods thereof.
    Type: Application
    Filed: June 29, 2021
    Publication date: January 6, 2022
    Applicants: Regents of the University of Minnesota, New York Blood Center, Inc.
    Inventors: Frank Jonathan Lee, Qibin Geng, Jian Shang, Marc Jenkins, Sung-Wook Hong, Lanying Du, Wanbo Tai, Yushun Wan
  • Publication number: 20220002238
    Abstract: The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 6, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Carolyn A. FAIRBANKS, Herbert T. NAGASAWA, George L. WILCOX, Cristina D. PETERSON, Kelley F. KITTO
  • Patent number: 11217370
    Abstract: A permanent magnet may include a Fe16N2 phase in a strained state. In some examples, strain may be preserved within the permanent magnet by a technique that includes etching an iron nitride-containing workpiece including Fe16N2 to introduce texture, straining the workpiece, and annealing the workpiece. In some examples, strain may be preserved within the permanent magnet by a technique that includes applying at a first temperature a layer of material to an iron nitride-containing workpiece including Fe16N2, and bringing the layer of material and the iron nitride-containing workpiece to a second temperature, where the material has a different coefficient of thermal expansion than the iron nitride-containing workpiece. A permanent magnet including an Fe16N2 phase with preserved strain also is disclosed.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: January 4, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jian-Ping Wang, YanFeng Jiang
  • Patent number: 11217371
    Abstract: A bulk permanent magnetic material may include between about 5 volume percent and about 40 volume percent Fe16N2 phase domains, a plurality of nonmagnetic atoms or molecules forming domain wall pinning sites, and a balance soft magnetic material, wherein at least some of the soft magnetic material is magnetically coupled to the Fe16N2 phase domains via exchange spring coupling. In some examples, a bulk permanent magnetic material may be formed by implanting N+ ions in an iron workpiece using ion implantation to form an iron nitride workpiece, pre-annealing the iron nitride workpiece to attach the iron nitride workpiece to a substrate, and post-annealing the iron nitride workpiece to form Fe16N2 phase domains within the iron nitride workpiece.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: January 4, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jian-Ping Wang, Yanfeng Jiang
  • Patent number: 11214862
    Abstract: The disclosure describes techniques for forming hard magnetic materials including ??-Fe16N2 using chemical vapor deposition or liquid phase epitaxy and hard materials formed according to these techniques. A method comprises heating an iron source to form a vapor comprising an iron-containing compound; depositing iron from the vapor comprising the iron-containing compound and nitrogen from a vapor comprising a nitrogen-containing compound on a substrate to form a layer comprising iron and nitrogen; and annealing the layer comprising iron and nitrogen to form at least some crystals comprising ??-Fe16N2.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: January 4, 2022
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jian-Ping Wang, YanFeng Jiang