Patents Assigned to Regents of the University of Minnesota
  • Patent number: 10895843
    Abstract: Systems, devices, and methods are described herein for performing digital holography to analyze dynamics of fluid flow. According to some aspects of this disclosure, a Digital Fresnel Reflection Holography (DFRH) system, which is arranged to utilize light backscattered from particles in a fluid chamber to create a hologram that may be processed to analyze characteristics of fluid flow. The DFRH system may utilize light reflected from an imaging window disposed between a light source and a sampling volume, to be analyzed as a reference wave, to form an interference pattern and resultant hologram. According to some aspects of this disclosure, the DFRH techniques may provide simple, cost-effective mechanisms with improved performance over other techniques for analyzing fluid flow using holography.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: January 19, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jiarong Hong, Santosh Kumar Sankar
  • Patent number: 10894732
    Abstract: The present disclosure relates to wastewater treatment systems for attracting and retaining anaerobic ammonia oxidizing (anammox) bacteria, methods of treating wastewater using such wastewater treatment systems, and the like.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: January 19, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Paige Novak, Santiago Romero-Vargas Castrillon, Anndee Huff, Marc A. Hillmyer, Michael Tsapatsis
  • Patent number: 10893928
    Abstract: This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: January 19, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Robert Tranquillo, Zeeshan Syedain, Lee Meier
  • Patent number: 10888609
    Abstract: The present invention provides in certain embodiments compositions comprising at least one CD200 inhibitor, and methods of reversing or modulating immune suppression in a patient having a disease or disorder arising from abnormal cell growth, function or behavior, which method comprises administering to a patient in need thereof a CD200 inhibitor composition.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 12, 2021
    Assignee: Regents of the University of Minnesota
    Inventor: Michael Olin
  • Patent number: 10888875
    Abstract: Devices, systems, and methods for applying a dielectrophoretic force on a particle include: a cell defining at least one channel for confining the particle; and a first electrode and a second electrode electrically isolated from the first electrode, at least one of the first and second electrodes being formed from a two-dimensional (2D) material providing an atomically sharp edge. The first and second electrodes are arranged sufficiently close to one another and sufficiently close to the channel such that application of a sufficient voltage across the first and second electrodes generates an electric field in at least part of the channel, the electric field having an electric field gradient sufficient to apply the dielectrophoretic force on the particle in the channel.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: January 12, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Sang-Hyun Oh, Steven John Koester
  • Patent number: 10883069
    Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: January 5, 2021
    Assignees: Toyota Motor Corporation, Regents of the University of Minnesota
    Inventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
  • Patent number: 10886033
    Abstract: In some examples, the disclosure describes a film including a rare-earth element-doped metal stannate exhibiting an electrical conductivity of at least about 104 S/cm at room temperature, where the metal includes at least one of barium, strontium, calcium, or zinc.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: January 5, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Bharat Jalan, Abhinav Prakash, Tianqi Wang
  • Patent number: 10883992
    Abstract: The invention provides kinase substrates and methods comprising their use.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 5, 2021
    Assignees: Regents of the University of Minnesota, Yale University
    Inventors: Laurie L. Parker, Wei Cui, Benjamin Turk
  • Patent number: 10874092
    Abstract: Described herein is a method for producing a chimeric non-human animal expressing a human a MYF5, MYOD, MRF4 gene or a combination thereof gene comprising: a) generating an MYF5, MYOD, MRF4 or combination thereof null non-human animal cell, wherein both copies of the non-human MYF5, MYOD, MRF4 gene or combination thereof carry a mutation that prevents production of functional MYF5, MYOD, MRF4 protein or combination thereof in said non-human animal; b) creating a MYF5, MYOD, MRF4 or combination thereof null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said MYF5, MYOD, MRF4 or combination thereof null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an MYF5, MYOD, MRF4 or combination thereof null non-human blastocyst; c) introducing human stem cells into the MYF5, MYOD, MRF4 or combination null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudopregnant surrogate non-human
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: December 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Daniel J. Garry, Mary G. Garry, Naoko Koyano
  • Patent number: 10878985
    Abstract: A material may include at least one of BixSe(1-x), BixTe(1-x), or SbxTe(1-x), where x is greater than 0 and less than 1. In some examples, the material exhibits a Spin Hall Angle of greater than 3.5 at room temperature. The disclosure also describes examples of devices that include a spin-orbit torque generating layer, in which the spin-orbit torque generating layer includes at least one of BixSe(1-x), BixTe(1-x), or SbxTe(1-x), where x is greater than 0 and less than 1. In some examples, the spin-orbit torque generating layer exhibits a Spin Hall Angle of greater than 3.5 at room temperature.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: December 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Jian-Ping Wang, Mahendra DC, Mahdi Jamali, Andre Mkhoyan, Danielle Hickey
  • Patent number: 10874727
    Abstract: The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 29, 2020
    Assignees: The Trustees of the University of Pennsylvania, Regents of the University of Minnesota
    Inventors: James L. Riley, Carl H. June, Bruce R. Blazar, Keli Hippen
  • Patent number: 10869748
    Abstract: A vascular graft includes deformable sleeves that include an electrical component. The electrical component can be variable-resistance or piezoelectric, in embodiments, such that deformation of the sleeves due to pressure changes create or modify an electrical signal. A transponder can then transmit information relating to the pressure inside and outside of the vascular graft.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: December 22, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Michael Rosenberg, Sean Lester Moen, Jafar Golzarian
  • Patent number: 10872246
    Abstract: In one example, a computing system is configured to obtain orientation data describing an orientation of the camera and geolocation data describing a location of the camera. The computing system is further configured to select, from one or more candidate images from an image database and based at least on the orientation data and the geolocation data, a best-matched image for a current image captured by the camera. The computing system is also configured to determine a location of a vehicle lane in the current image based on at least one lane marker visible in the best-matched image and output at least one indication of the location of the vehicle lane.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: December 22, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Junaed Sattar, Jiawei Mo
  • Patent number: 10873257
    Abstract: A low-dropout (LDO) regulator. The LDO regulator includes a pass transistor, a charge pump connected to the pass transistor, and an error amplifier connected through the charge pump to the pass transistor, wherein the error amplifier receives a voltage VO from the pass transistor and generates a voltage VE based on the voltage VO, wherein the charge pump receives the voltage VE from the error amplifier, generates a voltage VE* that is lower than VE by an offset and supplies the voltage VE* as a gate voltage to the pass transistor.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: December 22, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Ramesh Harjani, Saurabh Chaubey
  • Patent number: 10869612
    Abstract: A transducer includes a planar coil coupled to a magnetic flux guide. The magnetic flux guide includes an array of nanowires. The transducer could include a plurality of magnetic flux guides and a plurality of planar coils stacked together. The flux guides and planar coils could alternative in the stacked configuration.
    Type: Grant
    Filed: January 1, 2017
    Date of Patent: December 22, 2020
    Assignees: Boston Scientific Scimed Inc., Regents of the University of Minnesota
    Inventors: Matthew Hein, Daniel J. Foster, David R. Wulfman, Bethanie J. H. Stadler
  • Patent number: 10866630
    Abstract: A method includes generating gate-level activity information of a processor design for all possible executions of a target application for any possible inputs to the target application. The method includes performing a constrained timing analysis on the processor design based on the gate-level activity information to determine a minimum operating voltage for executing the target application on the processor.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: December 15, 2020
    Assignees: Regents of the University of Minnesota, University of Illinois at Urbana-Champaign
    Inventors: Hari Cherupalli, Rakesh Kumar, John Sartori
  • Patent number: 10858627
    Abstract: Disclosed is a method to differentiate stern, progenitor or precursor cells comprising contacting said stem, progenitor or precursor cells with miR-130a, or an RNA having at least 95% identity thereto, so as to yield cells of endothelial lineage. Further disclosed are compositions comprising the endothelial lineage cells obtained and methods of using the compositions for treating diseases including cardiovascular diseases.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: December 8, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Daniel J. Garry, Naoko Koyano-Nakagawa, Mary G. Garry, Bhairab Singh
  • Publication number: 20200377474
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 3, 2020
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Joseph J. Topczewski, William C.K. Pomerantz, Angela S. Carlson, Huarui Cui, Anand Divakaran
  • Patent number: 10850588
    Abstract: APC systems and methods using vehicle mass to assess boardings and alightings of passengers on transit vehicles (e.g., buses). Vehicle mass is determined based on signaled information indicative of a pressure in one or more air bag circuits of an air ride suspension system of the vehicle. In some embodiments, pressure information from three air bag circuits of the vehicle are monitored and reviewed to determine vehicle mass. The passenger count can be estimated based on determined vehicle mass by an Additional Mass Method or an Event-Based Method for example.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: December 1, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: William Northrop, David Kittelson, Andrew Kotz
  • Patent number: 10854257
    Abstract: A magnetic device may include a layer stack. The layer stack may include a first ferromagnetic layer; a non-magnetic spacer layer on the first ferromagnetic layer, where the non-magnetic spacer layer comprises at least one of Ru, Ir, Ta, Cr, W, Mo, Re, Hf, Zr, or V; a second ferromagnetic layer on the non-magnetic spacer layer; and an oxide layer on the second ferromagnetic layer. The magnetic device also may include a voltage source configured to apply a bias voltage across the layer stack to cause switching of a magnetic orientation of the second ferromagnetic layer without application of an external magnetic field or a current. A thickness and composition of the non-magnetic spacer layer may be selected to enable a switching direction of the magnetic orientation of the second ferromagnetic layer to be controlled by a sign of the bias voltage.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: December 1, 2020
    Assignees: Regents of the University of Minnesota, Carnegie Mellon University
    Inventors: Jian-Ping Wang, Delin Zhang, Sara A. Majetich, Mukund Bapna