Abstract: An integrated speed prediction framework based on historical traffic data mining and real-time V2I communications for CAVs. The present framework provides multi-horizon speed predictions with different fidelity over short and long horizons. The present multi-horizon speed prediction is integrated with an economic model predictive control (MPC) strategy for the battery thermal management (BTM) of connected and automated electric vehicles (EVs) as a case study. The simulation results over real-world urban driving cycles confirm the enhanced prediction performance of the present data mining strategy over long prediction horizons. Despite the uncertainty in long-range CAV speed predictions, the vehicle level simulation results show that 14% and 19% energy savings can be accumulated sequentially through eco-driving and BTM optimization (eco-cooling), respectively, when compared with normal-driving and conventional BTM strategy.

Abstract: Methods of treating or preventing microbial infection in a subject in need of treatment by administering a therapeutically effective amount of ergothioneine, or functional analog, or prodrug, or salt thereof. Ergothioneine may be advantageously administered in conjunction with lactoferrin.

Abstract: A method includes receiving patient health data; determining a score using a trained machine learning model; determining a threshold value using an adaptive threshold tuning learning model; comparing the score to the threshold value; and generating an alarm. A computing system includes a processor; and a memory having stored thereon instructions that, when executed by the processor, cause the computing system to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause a computer to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared with the otherwise identical fucosylated antibodies. The invention includes uses, and associated methods of using the antibodies.

Abstract: In certain examples, methods and semiconductor structures are directed to an integrated circuit (IC) having a diamond layer section and a GaN-based substrate being monolithically integrated or bonded as part of the same IC. In a specific example, the GaN-based substrate includes GaN, AlxGayN (0<x<1; x+y=1) and a dielectric layer, and a diamond layer section which may include polycrystalline diamond. The IC includes: a GaN-based field effect transistor (FET) integrated with a portion of the GaN-based substrate, and a diamond-based FET integrated with a portion of the diamond layer section, the diamond FET being electrically coupled to the GaN-based FET and situated over or against a surface region of the GaN-based substrate.

Abstract: Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

Abstract: Due to geometric discontinuities introduced by welding and joining processes, stresses or strain cannot be calculated reliably calculated using modern analytical and computer methods as result of stress or strain singularity at joint locations, which leads to severe mesh sensitivity. Design and fatigue evaluation of these structures remain empirical. This disclosure addresses mesh insensitivity of stress/strain calculations for welded structures through a cut-plane traction stress method through a novel post processing of conventional finite element computation results, as well as provides a unified fatigue evaluation procedure for fatigue design and structural life evaluation for both low-cycle and high cycle fatigue regime subjected to either proportional or non-proportional multiaxial fatigue loading, as well as a simple and reliable method for treating spot welds.

Abstract: Provided are methods of treating various forms of hearing loss caused by aberrant calcium fluxes in auditory cells. The methods encompass the administration of agents which prevent abnormal calcium fluxes, stabilize SERCA2b activity, or prevent ER UPR apoptotic responses. The methods include therapeutic treatments of subjects suffering from hearing loss as well as preventative treatments which protect auditory cells from cell death, for example as caused by exposure to loud noise.

Abstract: Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function.

Abstract: Disclosed herein are electrolytes and electrochemical devices. The electrochemical devices comprise cathodes that include nickel-rich layered lithium transition metal oxides, lithium-rich layered transition-metal oxides, lithium manganese-based spinel oxides, lithium polyanion-based compounds, and combinations thereof. The electrolytes include a lithium imide salt, an aprotic acyclic carbonate solvent, and an additive, wherein the additive comprises a metal salt, an aprotic solvent, or a combination thereof. The electrolyte can be stable at a voltage of 4.3 V or above vs. Li/Li+.

Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.

Abstract: Described herein are devices and methods utilizing cascade photocatalysis to drive multiple chemical reactions via a series of photoelectrochemical catalysts driven by the conversion of light into current by one or more photovoltaic devices. The described devices and methods are tunable and may be used in conjunction with different reactants and products, including the conversion of carbon dioxide into valuable hydrocarbon products.

Abstract: System and device configurations, and processes are provided for determining position based on low Earth orbit (LEO) satellite signals. Frameworks described herein can include performing Doppler frequency measurement for received quadrature phase shift keying (QPSK) signals. The framework may include channel tracking operations to determine Doppler shift measurements, a navigation filter operation to determine clock drift based on each Doppler shift measurement from each channel tracking loop, and determining position of a device based on LEO satellite signal sources. Frameworks described herein are also provided for carrier phase differential (CD)—low Earth orbit (LEO) (CD-LEO) measurements that may utilize a base and a rover without requiring prior knowledge of rover position. Embodiments can also cancel effects of ionospheric and tropospheric delays on the carrier phase and CD-LEO measurements.

Abstract: According to some aspects of the present disclosure, an atomic clock and methods of forming and/or using an atomic clock are disclosed. In one embodiment, an atomic clock includes: a light source configured to illuminate a resonance vapor cell; a narrowband optical filter disposed between the light source and the resonance vapor cell and arranged such that light emitted from the light source passes through the narrowband optical filter and illuminates the resonance vapor cell. The resonance vapor cell is configured to emit a signal corresponding to a hyperfine transition frequency in response to illumination from the light source, and a filter cell is disposed between the light source and the resonance vapor cell and configured to generate optical pumping. An optical detector is configured to detect the emitted signal corresponding to the hyperfine transition frequency.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.

Abstract: Provided herein are devices comprising one or more cells, and methods for fabrication thereof. The devices may be electrochemical devices. The devices may include three-dimensional supercapacitors. The devices may be microdevices such as, for example, microsupercapacitors. In some embodiments, the devices are three-dimensional hybrid microsupercapacitors. The devices may be configured for high voltage applications. In some embodiments, the devices are high voltage microsupercapacitors. In certain embodiments, the devices are high voltage asymmetric microsupercapacitors. In some embodiments, the devices are integrated microsupercapacitors for high voltage applications.

Abstract: A computer implemented method or system for creating a route for navigating a transit hub or plaza using an application executing on a user's mobile device. The application accesses a tessellated map comprising first tiles each including a different area of interest on the map; and second tiles including a walkable area connecting the different areas of interest. The application highlights one of the first tiles including one of the different areas of interest selected using input from the user; highlights one of the second tiles including a location of the mobile device on the map; and highlights a series of the second tiles linking the location to the one of the areas of interest. A method of creating the tessellated map is also disclosed.

Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.