Patents Assigned to Rensselaer Polytechnic Institute
  • Patent number: 10529440
    Abstract: Method, system and computer program product are provided for estimating a circadian phase of a subject by: obtaining a sensed biological signal for the subject; and using, by one or more processors, adaptive frequency tracking to adaptively estimate the circadian phase of the subject from the sensed biological signal. Circadian phase estimation may be accelerated by providing a feedback loop for the adaptive frequency tracking, which utilizes, in part, a circadian phase model in automatically ascertaining a phase correction for the adaptive frequency tracking. The circadian phase estimation may be used in automatically constructing a light-based circadian rhythm model for the subject using a linear parameter-varying (LPV) formulation, and once constructed, the circadian rhythm model for the subject may be used to provide light-based circadian rhythm regulation.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: January 7, 2020
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Jiaxiang Zhang, John T. Wen, Agung Julius
  • Patent number: 10527258
    Abstract: A light fixture includes a light source, a wavelength-conversion material, and a reflector. The light source is configured to emit a first radiation, and has a front surface and a back surface. The wavelength-conversion material is arranged under the front surface and configured to convert the first radiation to a second radiation which has a first portion not able to reach the reflector and a second portion able to reach the reflector. The reflector is arranged over the back surface and configured to reflect the second portion away from the light source without passing through the wavelength-conversion material. The reflector has an end distant from the light source and is arranged in an elevation different from that of the wavelength-conversion material.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 7, 2020
    Assignee: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Nadarajah Narendran, Yimin Gu, Jean Paul Freyssinier, Yiting Zhu
  • Publication number: 20190383835
    Abstract: Methods and systems directed to monitoring for the presence or progression of amyloid diseases via detection of amyloid fibrils in a sample from an individual are disclosed. An individual, or sample from an individual, is treated with a reagent including a fluorescent protein. The fluorescent protein in the reagent binds to amyloid fibrils present in the sample. Detecting a signal from fluorescent protein bound to the treated sample indicates the presence of amyloid fibrils in the sample and possible diagnosis of an amyloid disease. The presence and progression of an amyloid disease is monitored by quantifying signal intensity from samples taken over time. Treatment with a reagent including a fluorescent protein inhibits amyloid fibril formation by providing the reagent to an environment including amyloid monomers. The fluorescent protein binds to amyloid oligomers during the lag phase and/or elongation phase of amyloid fibril formation, preventing formation of mature amyloid fibrils.
    Type: Application
    Filed: January 23, 2018
    Publication date: December 19, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: George I. MAKHATADZE, Changmingzi XU-FUERY, Josephine Grace LoRICCO, Nathan JAMES, Anthony Charles BISHOP
  • Patent number: 10502246
    Abstract: Methods and systems for controlling a fluid flow field near a surface are disclosed. In some embodiments, the system includes an array of oscillating bodies disposed on the surface to provide physical modification to the flow field. Fluid jets are also emitted from an outlet in the oscillating body to provide virtual modification of the flow field through momentum addition. Fluid jet sources, including synthetic jet generators such as piezoelectric drivers and sources of compressed fluids such as air or water, are positioned to be in fluid communication with the outlet at intervals during the oscillation of the oscillating body. Controlling the oscillation amplitude and frequency of the body, as well as the location of oscillating body outlets and frequency of fluid jet emission, have advantageous effects for the surface such as improved heat transfer properties and reduction in structural vibration and noise.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: December 10, 2019
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Michael Amitay, Samantha Gildersleeve
  • Patent number: 10489942
    Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 26, 2019
    Assignees: RENSSELAER POLYTECHNIC INSTITUTE, SHANDONG UNIVERSITY, SHANDONG PROVINCIAL CHEST HOSPITAL, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Wenxiang Cong, Ye Yangbo, Ge Wang, Shuwei Mao, Yingmei Wang
  • Patent number: 10492334
    Abstract: Methods, systems, and assemblies for cooling an electronic component are disclosed. A heat sink assembly includes first and second substrates. The first substrate is in thermal contact with the electronic component. A primary channel is formed in the second surface of the first substrate. The primary channel is configured to direct cooling fluid for cooling the electronic component. An array of primary cooling fluid fins is positioned within the primary channel. The array of primary cooling fluid fins includes upstream solid fins and downstream open fins each having an upstream opening and downstream sidewalls. The secondary channel is formed within the second surface of the second substrate and is configured to direct partially heated cooling fluid away from the electronic component. An array of secondary cooling fluid fins is positioned within the secondary channel downstream. An enclosing layer seals the secondary channel.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 26, 2019
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Corey Christopher Woodcock, Joel L. Plawsky, Yoav Peles, Xiangfei Yu
  • Publication number: 20190345302
    Abstract: A method for modifying a polymeric surface is disclosed. The polymeric surface is activated utilizing atmospheric pressure plasma. An atom transfer radical polymerization initiator is then coupled to the activated surface. A monomer is then polymerized on the activated surface utilizing an activators regenerated by electron transfer (ARGET) atom transfer radical polymerization (ATRP) process. The method enables brush-modification of the polymeric surface, even if the polymeric surface is substantially chemically inert. By way of example, the method enables a chemically inert, substantially hydrophobic polymer surface to be functionalized with substantially hydrophilic polymer brushes. The methods of the present disclosure have general applicability to a myriad of implementations where tunable surface chemistry is advantageous, such as filtration membranes, marine surfaces, and medical devices seeking a biocompatible coating.
    Type: Application
    Filed: September 8, 2017
    Publication date: November 14, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: John Joseph KEATING, Georges BELFORT, Istvan Zsolt KOCSIS, Mirco SORCI, Alexander Kenneth LEE
  • Publication number: 20190337984
    Abstract: Disclosed herein are novel anti-microbial peptides with inhibitory activity against M. tuberculosis and streptococcus bacteria. Additionally, a method for designing novel anti-microbial peptides is disclosed.
    Type: Application
    Filed: May 14, 2019
    Publication date: November 7, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Georges BELFORT, C. Seth PEARSON, Brian MURRAY, Pankaj Sakharam KARANDE, Jun Ha KWAK, Kathleen A. MCDONOUGH, Zachary Andrew KLOOS
  • Publication number: 20190332928
    Abstract: A second order neuron for machine learning is described. The second order neuron includes a first dot product circuitry and a second dot product circuitry. The first dot product circuitry is configured to determine a first dot product of an intermediate vector and an input vector. The intermediate vector corresponds to a product of the input vector and a first weight vector or the input vector and a weight matrix. The second dot product circuitry is configured to determine a second dot product of the input vector and a second weight vector. The input vector, the intermediate vector, the first weight vector and the second weight vector each contain a number, n, elements.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 31, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Ge Wang, Wenxiang Cong, Fenglei Fan
  • Publication number: 20190327813
    Abstract: Light-emitting diode (LED) driver systems that are scalable and can be used for N-color LED systems are provided. An LED system having N LED strings of different color can be efficiently driven with independently controllable constant current sources for each string from a single power source. The driver system can include a power converter having an inductor.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Kumar Modepalli, Leila Parsa
  • Publication number: 20190325621
    Abstract: Tomographic/tomosynthetic image reconstruction systems and methods in the framework of machine learning, such as deep learning, are provided. A machine learning algorithm can be used to obtain an improved tomographic image from raw data, processed data, or a preliminarily reconstructed intermediate image for biomedical imaging or any other imaging purpose. In certain cases, a single, conventional, non-deep-learning algorithm can be used on raw imaging data to obtain an initial image, and then a deep learning algorithm can be used on the initial image to obtain a final reconstructed image. All machine learning methods and systems for tomographic image reconstruction are covered, except for use of a single shallow network (three layers or less) for image reconstruction.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 24, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Ge WANG, Wenxiang CONG, Qingson YANG
  • Publication number: 20190308185
    Abstract: Embodiments of the invention relate generally to anion exchange membranes and, more particularly, to anion exchange membranes comprising a styrene block copolymer and methods for their manufacture. In one embodiment, the invention provides a polymer according to formula IV, wherein x and y are mol %, QA is or each of R1 and R2 is, independently, a linear alkyl chain or a cyclic alkyl chain, and Z is selected from a group consisting of: a linear alkyl chain, a cyclic alkyl chain, and an alkylene ether chain.
    Type: Application
    Filed: March 13, 2019
    Publication date: October 10, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Chulsung Bae, Angela Dee Mohanty
  • Patent number: 10435504
    Abstract: Embodiments of the invention relate to a novel class of polymers with superior mechanical properties and chemical stability, as compared to known polymers. These polymers are particularly well suited for use in anion exchange membranes (AEMs), including those employed in fuel cells. Novel methods for the manufacture of these polymers are also described.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 8, 2019
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Chulsung Bae, Woo-hyung Lee
  • Patent number: 10413391
    Abstract: One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: September 17, 2019
    Assignees: Rensselaer Polytechnic Institute, The Johns Hopkins University
    Inventors: Andres Hurtado, Ryan J. Gilbert, Han B. Wang, Jared M. Cregg, Michael E. Mullins, Martin Oudega
  • Publication number: 20190277134
    Abstract: Systems and methods for transmitting power and information using acoustic energy produced by transducers are provided. The systems have particular application for powering and communication with electronics through drilling and pipe systems. Pairs of acoustic wedges holding transducers are provided for sending energy and information through a substrate which may be a steel pipe. Each wedge has an angled transducer which can be used to produce shear waves. The waves propagate through the substrate and are received by a second acoustic wedge. The shear waves, on reaching the second acoustic wedge, are converted back into electrical signals by a second transducer. Tangential shear waves, high, shallow wave transmission angles, and direct steel-steel bonding between wedges and substrates may be used.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 12, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Henry A. SCARTON, Gary J. SAULNIER, Kyle R. WILT, R. Benjamin LITMAN
  • Publication number: 20190280771
    Abstract: Methods and devices including a light display transceiver device are disclosed. Disclosed methods and devices include a light source array including at least one pixel unit, the at least one pixel unit including one of a single pixel, a plurality of groups of cooperating single pixels, a combination of singles pixels and groups of cooperating single pixels, and a single group of cooperating single pixels. Control wires are joined with each of the at least one pixel units. A controller is joined with the control wires for controlling each of the at least one pixel unit. The light source array is configured to operate in at least one of three modes, a full-space-division-duplex (FSDD) mode, a half-space-division-duplex (HSDD) mode, and a time-division-duplex (TDD) mode. The controller causes the light source array to operate in one of the three modes.
    Type: Application
    Filed: December 5, 2017
    Publication date: September 12, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Robert F. Karlicek, Bassem Fahs
  • Publication number: 20190269375
    Abstract: Systems and method for performing X-ray computed tomography (CT) that can improve spectral separation and decrease motion artifacts without increasing radiation dose are provided. The systems and method can be used with either a kVp-switching source or a single-kVp source. When used with a kVp-switching source, an absorption grating and a filter grating can be disposed between the X-ray source and the sample to be imaged. Relative motion of the filter and absorption gratings can by synchronized to the kVp switching frequency of the X-ray source. When used with a single-kVp source, a combination of absorption and filter gratings can be used and can be driven in an oscillation movement that is optimized for a single-kVp X-ray source. With a single-kVp source, the absorption grating can also be omitted and the filter grating can remain stationary.
    Type: Application
    Filed: March 6, 2019
    Publication date: September 5, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Daniel David Harrison, Ge Wang
  • Publication number: 20190267856
    Abstract: Advantageous machines, such as flux-switching machines (FSMs) are provided. An FSM can be yokeless and can have two rotors, which can be displaced from one another (e.g., by half a pole pitch). An FSM can be a flux-switching permanent magnet machine (FSPMM), and all magnets can be magnetized in the same circumferential direction. FSMs of the subject invention are cost-effective, have high torque density, and can operate well even under fault conditions.
    Type: Application
    Filed: May 14, 2019
    Publication date: August 29, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Arun GANDHI, Leila PARSA
  • Publication number: 20190261930
    Abstract: Methods and systems for stationary computed tomography are disclosed. The methods and systems include a gantry having alternating x-ray sources and x-ray detectors that are stationary during operation of the system. The gantry and pairs of x-ray sources and detectors substantially surrounds an object positioned inside the gantry during operation of the system. Dynamically adjustable collimators are positioned between the x-ray sources and the object. Each of the x-ray sources projects an x-ray beam through the collimators and through the object and the x-ray detectors receive the x-ray beam. The x-ray detectors include means for converting the x-ray beam to raw image data. One or more microprocessors control the x-ray sources and the process raw image data. A data storage device stores instructions, which upon execution by the microprocessor, control the x-ray sources and process the raw image data by converting the raw image data to a digital image.
    Type: Application
    Filed: November 7, 2017
    Publication date: August 29, 2019
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Ge Wang, Qingsong Yang, Wenxiang Cong
  • Publication number: 20190262295
    Abstract: Resolution of a pathological condition is promoted via the application, e.g., via injection, of a potassium osmolyte such as hyperosmolar potassium gluconate, potassium aspartate, another potassium-based salt, or combinations thereof to the condition site. The application of the potassium osmolyte increases the extracellular concentration of potassium ions, reducing the membrane potential of the cells at the condition site and including immune cell quiescence. As a result, the inflammatory response in the patient to the pathological condition is reduced or eliminated. Reducing the inflammatory response is useful in treatment of myriad conditions including arthritis, auto-immune conditions, inflammatory disorders, neurodegenerative disorders, neurodevelopmental disorders, tissue breakdown, etc.
    Type: Application
    Filed: February 26, 2019
    Publication date: August 29, 2019
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Joshua Erndt-Marino, Mariah Hahn