Patents Assigned to Research Development
  • Image sensor with improved dynamic range
    Patent number: 9313427
    Abstract: An image sensor having improved dynamic range includes a signal that is read out for a selection of pixels which act as a calibration to govern the choice of exposure levels to be applied to the rest of the array. In this way, the sensor is operable to adapt to variations in scene intensity. The pixels in the array are vertically and horizontally addressed so as to enable accounted for small areas of intensity variation across an imaged scene.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: April 12, 2016
    Assignees: STMicroelectronics (Grenoble 2) SAS, STMicroelectronics (Research & Development) Limited
    Inventors: John Kevin Moore, Matthew Purcell, Graeme Storm, Tarek Lule
  • Field emission device and method of fabricating the same
    Patent number: 9306167
    Abstract: A field-emission device is disclosed. The device comprises a solid state structure formed of a crystalline material and an amorphous material, wherein an outer surface of the solid state structure is substantially devoid of the amorphous material, and wherein a p-type conductivity of the crystalline material is higher at or near the outer surface than far from the outer surface.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: April 5, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Rafael Kalish, Moshe Tordjman
  • Polymeric compositions and uses thereof
    Patent number: 9306168
    Abstract: Provided are thermo-sensitive and light-sensitive polymer compositions including poly(4-vinyl pyridine) and poly(4-vinyl pyridine-co-butyl methacrylate).
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: April 5, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Evgenia Vaganova, Shlomo Yitzchaik
  • Methods and systems for managing a multi participant event
    Patent number: 9305284
    Abstract: A method for managing communication among a plurality of social network members. The method comprises defining a multi participant task, setting at least one forward rule limiting the distribution an invitation message for participating in the multi participant task, forwarding the invitation message to at least one addressee from a plurality of social network members, allowing the at least one addressee to forward the invitation message to at least one additional addressee from the plurality of social network members under the at least one forward rule, monitoring a plurality of feedbacks to the invitation message to determine whether the multi participant task is achieved, and updating a status of the multi participant task according to the determination.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: April 5, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Oded Shmueli, Royi Ronen
  • MO-1 conditional knock-out non-human animal and uses thereof
    Patent number: 9295239
    Abstract: A conditional knock-out non-human animal is disclosed. Wherein some cells of the non-human animal but not all the cells comprise a disrupted MO-1 nucleic acid sequence, wherein the disruption results in an inability of the non-human animal to produce detectable levels of the MO-1 protein, as assayed by Southern blot analysis.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: March 29, 2016
    Assignee: Medical Research & Development Fund for Health Services Bnai Zion Medical Center, THE STATE OF ISRAEL
    Inventor: Zvi Borochowitz
  • Method for detecting non-transferrin bound iron
    Patent number: 9291619
    Abstract: A method of quantifying non-transferrin bound iron (NTBI) in a biological fluid is provided, the method comprising: (a) contacting a sample of the biological fluid with a reducing agent to obtain redox-active iron; (b) contacting the sample of the biological fluid with a nitrilotriacetate (NTA) at a concentration of 0.4-2 mM to mobilize non-transferrin bound iron including redox inactive and the redox active iron in the sample; (c) contacting the sample of the biological fluid of step (b) with an indicator including an iron binding moiety and fluorophore; and (d) detecting and quantifying a fluorescent signal of the fluorophore thereby quantifying the NTBI in the biological sample.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: March 22, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ioav Zvi Cabantchik, William Breuer
  • METHODS AND COMPOSITIONS RELATING TO IMPROVED LENTIVIRAL VECTORS AND THEIR APPLICATIONS
    Publication number: 20160068862
    Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.
    Type: Application
    Filed: April 22, 2015
    Publication date: March 10, 2016
    Applicant: Research Development Foundation
    Inventors: Didier TRONO, Patrick SALMON
  • Wideband light energy waveguide and detector
    Patent number: 9281424
    Abstract: An electromagnetic energy concentrator uses a prism and waveguide with a gap layer of uniform thickness disposed between the prism and a first surface of waveguide. Energy detectors, which may be photovoltaics or miniaturized antenna elements are disposed adjacent to and co-extensive with a second surface of the waveguide. The detectors operate in each of at least two bands; a distance between detectors operating in a given band depends on a wavelength in the given band.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: March 8, 2016
    Assignee: AMI Research & Development, LLC
    Inventors: Patricia Bodan, John T. Apostolos, Benjamin McMahon, William Mouyos
  • Stacked bow tie array with reflector
    Patent number: 9281566
    Abstract: A stacked bow tie antenna array structure is placed within, for example a rectangular reflector. Spaces between the bow tie elements and the reflector are filled with close spaced conductive plates.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: March 8, 2016
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Judy Feng, William Mouyos
  • pH gradients controlled by electrolysis, and their use in isoelectric focusing
    Patent number: 9274082
    Abstract: A specified proton concentration in a volume (80) is produced by passing a controlled electrophoresis current through an adjacent electrophoresis volume (28) between a working electrode (26) and a counter electrode (24). An array of such volumes with specified proton concentration is used to provide the pH gradient for isoelectric focusing.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: March 1, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Uri Sivan, Elad Brod
  • Compositions comprising fibrous polypeptides and polysaccharides
    Patent number: 9273152
    Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: March 1, 2016
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.
    Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel
  • Johnson ambient-heat engine
    Patent number: 9266085
    Abstract: An ambient-heat engine has a substantially thermally-conductive housing whose interior is divided into a high-pressure chamber and a low-pressure chamber by a substantially gas-impermeable barrier. An ionically-conductive, electrical-energy-generating mechanism forms at least a portion of the barrier. First hydrogen-storage medium is disposed within the high-pressure chamber and second hydrogen-storage medium is disposed within the low-pressure chamber. An electrical-energy storage device connected to the ionically-conductive, electrical-energy-generating mechanism is operable between a charge condition and a discharge condition. In a charge condition, hydrogen atoms within the high-pressure chamber are converted to hydrogen ions and conducted through the electrical-energy-generating mechanism to the low-pressure chamber causing electrical-energy to be generated to the electrical-energy storage device.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: February 23, 2016
    Assignee: Johnson Research & Development Co. Inc.
    Inventor: Lonnie G. Johnson
  • Human monoclonal antibodies to human nucleolin
    Patent number: 9260517
    Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: February 16, 2016
    Assignee: MUSC Foundation for Research Development
    Inventors: Natalie Sutkowski, Daniel Fernandes, Brian Hoel, Semyon Rubinchik
  • Methods and compositions relating to improved lentiviral vector production systems
    Patent number: 9260725
    Abstract: The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurine tract, a stuffer sequence, which may encode drug susceptibility genes, and a mutated hairpin in the 5? leader sequence that substantially abolishes replication. These elements are provided in conjunction with other features of lentiviral vectors, such as a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: February 16, 2016
    Assignee: Research Development Foundation
    Inventors: Didier Trono, Romain N. Zufferey
  • Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
    Patent number: 9255271
    Abstract: The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: February 9, 2016
    Assignee: Technion Research & Development Foundation Ltd
    Inventor: Gera Neufeld
  • Method and apparatus for enhancing a digital photographic image
    Patent number: 9256927
    Abstract: A method and apparatus for enhancing a digital photographic image uses a combination of global and content-specific operations. Image data is analyzed to detect one or more content items in the image to be separately enhanced. Then a content-specific enhancement operation is performed on data representing at least one detected content item, separately from the remainder of the image data. Several such content-specific operations may be performed for different types of content item. The content-specific enhancement operation comprises manipulating data, and the manipulation applies different adjustments to different pixels in the detected content item and the determination of the adjustments is based solely on analysis of the image data. Then a different enhancement operation is performed on at least the remaining image data excluding said one or more detected content items.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: February 9, 2016
    Assignee: Yissum Research Development Companyof The Hebrew University of Jerusalem Ltd.
    Inventors: Daniel Lischinski, Michael Werman, Liad Kaufman
  • Motor integrated to electronic device
    Patent number: 9257876
    Abstract: An electronic device includes a first structural part, a first electronic substrate correspondingly mounted on the first structural part, and a motor. The motor includes a second structural part and a second electronic substrate, a base directly formed on the second structural part, a rotor having at least one load, and a stator. The first and second structural parts are integrally made. The first and second structural parts are combined to a single electronic structural part. The stator has a plurality of winding coils and a driving circuit directly shaped on the second electronic substrate respectively for driving the rotor. The first and second electronic substrates are integrally made. The first and second electronic substrates are combined to a single electronic substrate. Alternatively, the driving circuit is directly shaped in the second electronic substrate.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: February 9, 2016
    Assignee: Metal Industries Research & Development Centre
    Inventors: Guang-Miao Huang, Guo-Jhih Yan, Hsin-Te Wang, Jing-Hui Wang
  • Methods of deriving mammalian pluripotent stem cell lines
    Patent number: 9255247
    Abstract: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: February 9, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • ENCAPSULATION OF BACTERIA AND VIRUSES IN ELECTROSPUN FIBERS
    Publication number: 20160032271
    Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 4, 2016
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Jonathan Charles KUHN, Eyal ZUSSMAN
  • PIXEL ARRAY AND METHOD FOR CONTROLLING A PIXEL ARRAY
    Publication number: 20160037105
    Abstract: A pixel array includes pixels arranged in columns. A pair of column lines is provided for each column of pixels. A current source circuit is coupled to each pair of column lines. The current source circuit provides current to the pair of column lines in a first mode of operation such that when one column line in a pair of column lines is being provided with a first current the other column line in the pair of column lines is being provided with a second current which is less than the first current.
    Type: Application
    Filed: June 5, 2015
    Publication date: February 4, 2016
    Applicants: STMicroelectronics (Research & Development) Limited, The University Court of the University of Edinburgh
    Inventors: Shatabda Saha, John Kevin Moore