Patents Assigned to Research Foundation of The City University of New York
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Patent number: 11378066Abstract: A robot for cleaning and inspecting wind turbine blades. The robot has a module that adheres to the blade using a vacuum force. The robot also has a cleaning compartment is divided into two sections that are connected by a flexible section. The cleaning compartment is flexible such that it adapts to convex and concave curvatures on the blade.Type: GrantFiled: February 28, 2020Date of Patent: July 5, 2022Assignees: InnovBot, LLC, Research Foundation of the City University of New YorkInventors: Jizhong Xiao, Guoyong Yang, Yifeng Song
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Patent number: 11345725Abstract: This disclosure describes three novel bisthioether stapled peptides as allosteric inhibitors of Polycomb Repressive Complex 2 (PRC2) catalytic function with demonstrated cell permeability, potent activity in physiological conditions, and strong antiproliferative effects on cancer cells. These inhibitors target, for the first time, two protein interfaces in PRC2 that are crucial for its proper assembling and thus for its histone methyltransferase activity.Type: GrantFiled: September 16, 2020Date of Patent: May 31, 2022Assignee: Research Foundation of the City University of New YorkInventors: Guillermo Gerona-Navarro, Gan Zhang, Flavia Barragan
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Publication number: 20220162209Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts or tautomers thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., Mycobacterium infection (e.g., tuberculosis)).Type: ApplicationFiled: December 20, 2019Publication date: May 26, 2022Applicants: Memorial Sloan-Kettering Cancer Center, Research Foundation of the City University of New York, The Johns Hopkins UniversityInventors: Derek Shieh Tan, Lisa Charlotte Standke, Luis Edmundo Nereo Quadri, Glennon Valere Bythrow, William Ramses Bishai, Shichun Lun
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Patent number: 11342548Abstract: A zinc electrode comprises an anode material, the anode material comprising: an electroactive material comprising at least one of zinc or a compound comprising zinc, a stabilizer additive comprising at least one of: bismuth, copper, indium, a compound comprising bismuth, a compound comprising copper, a compound comprising indium, or any combination thereof, a conductive additive, and a binder.Type: GrantFiled: November 22, 2019Date of Patent: May 24, 2022Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Gautam G. Yadav, Jungsang Cho, Xia Wei, Michael Nyce, Sanjoy Banerjee
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Patent number: 11325112Abstract: Nanocages are formed by etching nanocubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e.g. a hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell).Type: GrantFiled: May 18, 2020Date of Patent: May 10, 2022Assignee: Research Foundation of the City University of New YorkInventors: Hiroshi Matsui, Zengyan Wei, Justin Fang
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Patent number: 11297500Abstract: A digital media authentication system comprises a media processing application executed by a mobile electronic device that computes a robust image hash for media data acquired by the mobile electronic device; a location attestation system that validates a location context of the media data, the location context determined in response to an object scene in a field of view of the mobile electronic device captured for conversion to the media data; and a blockchain network that maintains a ledger entry that includes the robust image hash, an immutable timestamp, and a location certificate validating the location context of the media data.Type: GrantFiled: April 15, 2020Date of Patent: April 5, 2022Assignee: Research Foundation of the City University of New YorkInventor: Shweta Jain
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Patent number: 11276877Abstract: A battery comprises a housing, an electrolyte disposed in the housing, an anode disposed in the housing, a stabilized cathode disposed in the housing and comprising a cathode material. The cathode material comprises a composition selected from birnessite or layered-polymorph of manganese dioxide (?-MnO2), the composition being stabilized by bismuth and copper ions, a conductive carbon, and a binder. The anode can be at least 50% (m/m) lithium, magnesium, aluminum, or zinc.Type: GrantFiled: May 4, 2018Date of Patent: March 15, 2022Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Gautam G. Yadav, Michael Nyce, Jinchao Huang, Alexander Couzis, Sanjoy Banerjee
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Patent number: 11255830Abstract: A biosensor for detecting trinitrotoluene (TNT) is disclosed. The biosensor has cells, such as olfactory sensory neurons (or cilia derived therefrom), that preferentially express a TNT-responsive odorant receptor protein.Type: GrantFiled: January 2, 2018Date of Patent: February 22, 2022Assignee: Research Foundation of the City University of New YorkInventors: Paul Feinstein, Charlotte D'Hulst
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Patent number: 11225666Abstract: A method for cloning an exon into a plasmid vector. Exons related to prostate cancer (PVT1 exon 9, PVT1 exon 4A or PVT1 exon 4B) and miRNAs (miR-1205 or miR-1207-3p) are transformed into the plasmid vector. The cloned exons or miRNAs are linearized and their concentrations quantified. Serial dilutions in conjunction with spectroscopy permit the construction of a standard curve that permits absolute quantification of the exons or miRNAs in a biological sample from a patient.Type: GrantFiled: March 18, 2019Date of Patent: January 18, 2022Assignee: Research Foundation of the City University of New YorkInventors: Olorunseun O. Ogunwobi, Gargi Pal
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Publication number: 20210393548Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.Type: ApplicationFiled: May 12, 2021Publication date: December 23, 2021Applicants: Saint Louis University, Research Foundation of The City University of New York, National and Kapodistrian University of AthensInventors: John Edwin TAVIS, Grigoris ZOIDIS, Amelia PINTO, James BRIEN, Ryan MURELLI
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Patent number: 11141490Abstract: Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.Type: GrantFiled: July 5, 2019Date of Patent: October 12, 2021Assignees: Research Foundation of the City University of New York, Memorial Sloan Kettering Cancer CenterInventors: Maria Contel, Natalia Curado, Jason Lewis, Sophie Poty
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Patent number: 11118150Abstract: A layered, microfluidic array is disclosed. The array has a first layer with a culture channels extending in a first longitudinal direction. Each culture channel includes multiple traps that entrap cell or tissue samples. The array also has a second layer with microfluidic channels extending in a second longitudinal direction that is orthogonal the first longitudinal direction. A third layer, disposed between the first layer and the second layer, has pores arranged within the third layer such that each nest is vertically stacked above, and fluidly connected with, a corresponding culture chamber in the first layer. Each nest is fluidly isolated from adjacent nests by a fluid impermeable region of the third layer such that horizontal diffusion of water within the third layer is prevented.Type: GrantFiled: January 10, 2019Date of Patent: September 14, 2021Assignees: Research Foundation of the City University of New York, Memorial Sloan Kettering Cancer CenterInventors: Sihong Wang, A. H. Rezwanuddin Ahmed, Xuejun Jiang, Chun-wei Chi, Chenghai Li
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Patent number: 11119064Abstract: An impedance spectroscopy biosensor is provided that is fabricated on a stretchable substrate. The stretchable substrate is integrated with an impedance biosensor that undergoes cyclic strain without cracking. The biosensor is formed by curing an elastomer precursor while on a pre-tensioned membrane that includes a conductive electrode. The resulting elastomeric material is released from the support after curing which releases the pre-tensioned state to produce the biosensor.Type: GrantFiled: July 22, 2019Date of Patent: September 14, 2021Assignee: Research Foundation of the City University of New YorkInventors: Ioana Voiculescu, Xudong Zhang
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Patent number: 11091468Abstract: Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against the Zika (ZIKV) virus. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.Type: GrantFiled: July 23, 2019Date of Patent: August 17, 2021Assignees: Research Foundation of the City University of New York, Texas Tech University SystemInventors: Adam B. Braunschweig, Kalanidhi Palanichamy, M. Fernando Bravo, Milan A. Shlain, Himanshu Garg, Anjali Joshi
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Patent number: 11034946Abstract: A engineered alpha-galactosidase A polypeptide comprising SEQ ID NO: 1 having at least one non-glycosylation mutation; and at least one glycosylation compensatory mutation is claimed.Type: GrantFiled: October 5, 2018Date of Patent: June 15, 2021Assignee: Research Foundation of The City University of New YorkInventors: David H. Calhoun, Erin S. Stokes, M. Lane Gilchrist
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Patent number: 11029692Abstract: A robotic device for providing vertical mobility has a payload disposed inside a central compartment and can move up and down through spring load to keep intimate contact with the surface and cross over bumps. The apparatus uses a flexible seal to create a reliable vacuum chamber. The flexible seal comprises a foam ring inside fabric pocket. A plurality of rod and spring strips are configured to apply a downward force to the flexible seal to conform with surface curvatures. The fabric pocket fills in the gaps or seams to maintain a vacuum. The air flows inside a manifold and passes through a filter to avoid debris from damaging the vacuum motor assembly.Type: GrantFiled: January 13, 2020Date of Patent: June 8, 2021Assignees: InnovBot, LLC, Research Foundation of the City University of New YorkInventors: Jizhong Xiao, Kenshin Ushiroda, SaiadiVishnu Sanigepalli, Guoyong Yang, Yifeng Song
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Patent number: 11021516Abstract: A self-assembling peptide is provided that is enzymatically oxidized to form a polymeric pigment. The monomeric peptide has three amino acids (tyrosine (Y), one phenylalanine (F), and one aspartic acid (D) or one lysine (K)) and, following self-assembly and treatment with a tyrosinase enzyme oxidizes and polymerizes into a material with predetermined properties.Type: GrantFiled: September 11, 2017Date of Patent: June 1, 2021Assignees: Research Foundation of the City University of New York, University of Strathclyde, Carnegie Mellon UniversityInventors: Rein V. Ulijn, Ayala Lampel, Tell Tuttle, Gary Scott, Scott McPhee, Christopher Bettinger
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Patent number: 11000604Abstract: A label for an antibody or protein is described that is both site-selective and unusually stable in vivo. The label has a general formula given by Formula (I) wherein R1 is a metal chelator, a fluorophore or a click-chemistry synthon.Type: GrantFiled: May 17, 2018Date of Patent: May 11, 2021Assignee: Research Foundation of the City University of New YorkInventors: Brian Zeglis, Pierre Adumeau, Maria Davydova
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Patent number: 10980754Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.Type: GrantFiled: April 19, 2017Date of Patent: April 20, 2021Assignees: SAINT LOUIS UNIVERSITY, RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Maureen J. Donlin, John Edwin Tavis, Ryan Murelli, Marvin J. Meyers
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Patent number: 10980460Abstract: The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.Type: GrantFiled: February 15, 2017Date of Patent: April 20, 2021Assignees: Research Foundation of The City University of New York, New York University School of MedicineInventors: Patricia A. Broderick, Steven V. Pacia