Patents Assigned to Research Foundation of The City University of New York
  • Patent number: 9698286
    Abstract: A quantum well infrared photodetector (QWIP) and method of making is disclosed. The QWIP includes a plurality of epi-layers formed into multiple periods of quantum wells, each of the quantum wells being separated by a barrier, the quantum wells and barriers being formed of II-VI semiconductor materials. A multiple wavelength QWIP is also disclosed and includes a plurality of QWIPs stacked onto a single epitaxial structure, in which the different QWIPs are designed to respond at different wavelengths. A dual wavelength QWIP is also disclosed and includes two QWIPs stacked onto a single epitaxial structure, in which one QWIP is designed to respond at 10 ?m and the other at 3-5 ?m wavelengths.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 4, 2017
    Assignees: THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Arvind Ravikumar, Claire Gmachl, Aidong Shen, Maria Tamargo
  • Patent number: 9688607
    Abstract: This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: June 27, 2017
    Assignee: Research Foundation of The City University of New York
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Patent number: 9688326
    Abstract: A drive unit for driving a robot along an inclined surface is disclosed. An endless tread engages a pair of wheels to define a planar bottom surface of the endless tread. A vacuum motor pulls air through holes in the endless tread when the holes are aligned with a vacuum opening.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 27, 2017
    Assignees: Research Foundation of The City University of New York, InnovBot, LLC
    Inventors: Jizhong Xiao, Kenshin Ushiroda
  • Patent number: 9677056
    Abstract: Methods are provided for modifying and screening for carotenoid biosynthesis in a plant. The methods are useful for enhancing plant adaptation to climate change and food security, providing increased carotenoid content to a plant, improving stress resistance to climate changes in a plant, and for selecting plants having improved stress resistance to climate changes.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: June 13, 2017
    Assignee: Research Foundation of The City University of New York
    Inventors: Eleanore T. Wurtzel, Maria Shumskaya
  • Patent number: 9650404
    Abstract: The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: May 16, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Krishnaswami Raja, Alejandra Alonso, Probal Banerjee, Sukanta Dolai, Christopher Corbo, Saadyah Averick, Amit Mogha, Shawon Debnath
  • Patent number: 9648876
    Abstract: Xanthochymol and garcinol, isoprenylated benzophenones purified from Garcinia xanthochymus fruits, showed multiple activities against fungal biofilms. Both compounds effectively prevented emergence of fungal germ tubes and were also cytostatic, with MICs of 1 to 3 ?M. The compounds therefore inhibited development of hyphae and subsequent biofilm maturation. Xanthochymol treatment of developing and mature biofilms induced cell death. In early biofilm development, killing had the characteristics of apoptosis. These activities resulted in failure of biofilm maturation and hyphal death in mature biofilms. In mature biofilms, xanthochymol and garcinol caused the death of biofilm hyphae, with 50% effective concentrations (EC50s) of 30 to 50 ?M. Additionally, xanthochymol-mediated killing was complementary with fluconazole against mature biofilms, reducing the fluconazole EC50 from greater than 1,024 ?g per ml to 13 ?g per ml.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: May 16, 2017
    Assignee: Research Foundation of City University of New York
    Inventors: Desmond N. Jackson, Edward N. Kennelly, Peter Lipke
  • Patent number: 9643995
    Abstract: In the present invention, different strategies are used to improve the bioavailability of triterpene glycosides and triterpenes including, for example, (a) a covalent approach involving modification with polyethylene glycol and (b) a formulation approach involving non-covalent encapsulation in antibody targeted pol(DL-lactic acid) nanoparticles.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 9, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Linda Saxe Einbond, Krishnaswami Raja
  • Publication number: 20170112897
    Abstract: The invention provides methods for treating brain insulin resistance and/or diseases associated therewith in a subject in need thereof. The methods include providing a composition comprising a dual GLP-1 receptor/GIP receptor (GLP-1R/GIPR) agonist and administering an effective amount of the composition to the subject to treat brain insulin resistance and diseases associated therewith.
    Type: Application
    Filed: October 24, 2016
    Publication date: April 27, 2017
    Applicants: Cedars-Sinai Medical Center, Research Foundation of The City University of New York
    Inventors: Konrad Talbot, Hoau-Yan Wang, Keith L. Black
  • Patent number: 9610319
    Abstract: A method of treating liver cancer using a peptide based on venom from a terebrid snail, terebrid variegata, is described. The venom has a general formula of TRX3CCGCYWNGSKDVCSQSCC (SEQ ID NO: 1) and variants thereof are described.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 4, 2017
    Assignees: Research Foundation of the City University of New York, The Rockefeller University
    Inventors: Mande Holford, Prachi Anand, Beatrix Ueberheide, Brian Chait
  • Patent number: 9561244
    Abstract: A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating Na+K+ATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: February 7, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventor: Linda Saxe Einbond
  • Patent number: 9555049
    Abstract: A method for providing a therapeutic benefit for a subject having a cancer is provided. A compound with an arene ruthenium (II) compound with an iminophosphorane ligand is administered to the subject.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 31, 2017
    Assignee: Research Foundation of the City University of New York
    Inventors: Maria Contel, Isabel Marzo, Malgorzata Frik, Benelita T. Elie
  • Patent number: 9556554
    Abstract: The disclosure relates to a superhydrophobic surface. Methods of fabrication are disclosed including laminating an optically transparent polymer sheet with hydrophobic nanoparticles such that the nanoparticles are partially embedded and partially exposed. The resulting assembly remains optically transparent. Additional methods include the lamination of nanoparticles to flexible fabrics and the production of molded articles using nanoparticle-treated molds.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: January 31, 2017
    Assignee: Research Foundation of the City University of New York
    Inventors: Alan Michael Lyons, QianFeng Xu
  • Patent number: 9539215
    Abstract: A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: January 10, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: George John, Praveen Vemula
  • Patent number: 9540957
    Abstract: Thermal storage systems that preferably do not create substantially any additional back pressure or create minimal additional back pressure and their applications in combined cycle power plants are disclosed. In one embodiment of the method for efficient response to load variations in a combined cycle power plant, the method includes providing, through a thermal storage tank, a flow path for fluid exiting a gas turbine, placing in the flow path a storage medium comprising high thermal conductivity heat resistance media, preferably particles, the particles being in contact with each other and defining voids between the particles in order to facilitate flow of the fluid in a predetermined direction constituting a longitudinal direction, arrangement of the particles constituting a packed bed, dimensions of the particles and of the packed bed being selected such that a resultant back pressure to the gas turbine is at most a predetermined back pressure.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: January 10, 2017
    Assignee: The Research Foundation of the City University of New York
    Inventors: Reuel Shinnar, Hitesh Bindra, Shlomo Shinnar, Meir Shinnar
  • Publication number: 20170000748
    Abstract: A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.
    Type: Application
    Filed: September 15, 2016
    Publication date: January 5, 2017
    Applicants: Research Foundation of the City University of New York, The Curators of the University of Missouri, University of North Texas
    Inventors: George John, Subbiah Nagarajan, Kent Chapman, Lionel Faure, Peter Koulen
  • Patent number: 9512559
    Abstract: In one embodiment, the invention relates to a method for rendering a non-metallic substrate stably antimicrobial. The method comprises: (a) contacting the substrate with an antimicrobial surfactant; (b) contacting the substrate with a polymeric binder; and (c) subjecting the substrate, surfactant, and binder to conditions at which the substrate becomes stably antimicrobial. In another embodiment, the invention relates to a substrate into which an antimicrobial surfactant and a binder have penetrated.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: December 6, 2016
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Robert Engel, Gary Innocenti, Karin Melkonian
  • Patent number: 9494552
    Abstract: Disclosed in this specification is a high capacity compact gel documentation system for documenting different types of electrophoresis gels or other translucent objects using ultraviolet light. The system includes a base with a scanning surface having a transparent bottom surface. A light source is connected to a conveying mechanism, disposed below the transparent bottom surface, to move the light source over the length of the transparent bottom surface. An image capture device receives a reflected image and provides it to a microprocessor. Moreover, separate interchangeable filters allow for documentation of UV and white light gel captures, alleviating the need for separate transilluminators and hoods with filters and cameras.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: November 15, 2016
    Assignee: Research Foundation of The City University of New York
    Inventors: Farshad Tamari, Farnaz Tamari
  • Patent number: 9486525
    Abstract: The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: November 8, 2016
    Assignee: The Research Foundation of the City University of New York
    Inventors: Linda Saxe Einbond, I. Bernard Weinstein
  • Patent number: 9485480
    Abstract: A laser projection system including one or more pluralities of laser sources, each plurality of laser sources emitting light having substantially a different predetermined wavelength in the visible range, a fiber optic laser beam combiner combining outputs of at least one of the pluralities of laser sources into one optical fiber, a fiber-optic delivery component coupled to the one optical fiber and one or more spatial light modulators, and one or more homogenizing optical elements, and one or more optical lens system for projecting the associated images on a screen.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: November 1, 2016
    Assignee: The Research Foundation of the City University of New York
    Inventors: Nicholas Madamopoulos, Fotini Papageorgiou
  • Patent number: 9481876
    Abstract: Human cathepsin L inhibitors and probes containing a vinyl sulfonate ester moiety are described. The inhibitors are highly potent (low nM affinity), selective, and cell permeable, and can inhibit ultra-low concentration of active cathepsin L. The developed probes are highly sensitive and can detect an ultra-low amount of probe-labeled active cathespin L.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: November 1, 2016
    Assignee: Research Foundation of the City University of New York
    Inventors: Sanjai Kumar, Dibyendu Dana