Patents Assigned to Rhode Island Hospital
  • Patent number: 10960065
    Abstract: The invention provides compositions and methods for preventing or reducing the severity of malaria.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: March 30, 2021
    Assignees: Rhode Island Hospital, Seattle Children's Hospital
    Inventors: Jonathan Kurtis, Christian Parcher Nixon, Dipak Kumar Raj, Jennifer Frances Friedman, Michal Fried, Patrick Emmet Duffy
  • Patent number: 10941447
    Abstract: This invention relates to a diagnostic test measuring circulating SCN5A proteins or gene transcripts in a test sample as a biomarker for pulmonary hypertension.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 9, 2021
    Assignee: Rhode Island Hospital
    Inventors: Samuel C. Dudley, Jr., Corey E. Ventetuolo
  • Patent number: 10835170
    Abstract: Disclosed are methods for detecting neuronal oscillation in the spinal cord of a subject. The methods can be utilized to determine that the subject has a disease or disorder of the spinal cord. The methods are useful for treating or reducing the likelihood of pain in a subject by detecting neuronal oscillation in the spinal cord and, e.g., administering a therapeutic agent to the subject. The electrode (LFP) methods disclosed herein may also be utilized to screen for a therapeutic agent that decreases neuronal oscillation in the spinal cord using a non-human animal subject.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: November 17, 2020
    Assignee: Rhode Island Hospital
    Inventor: Carl Saab
  • Patent number: 10813984
    Abstract: The present invention provides a peptide-based immunotherapy for ASPH-expressing tumors.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: October 27, 2020
    Assignee: Rhode Island Hospital
    Inventor: Jack R. Wands
  • Patent number: 10710995
    Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 14, 2020
    Assignees: Rhode Island Hospital, Midwestern University
    Inventors: Jack R. Wands, Suzanne De La Monte, Arihiro Aihara, Mark Jon Olsen, John-Michael Thomas
  • Patent number: 10677799
    Abstract: Ctsk is used as a marker to identify, track, and manipulate Ctsk positive cartilaginous stem cells for cartilage repair and regeneration in vitro and in vivo.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 9, 2020
    Assignee: Rhode Island Hospital
    Inventors: Wentian Yang, Nikhil Thakur
  • Patent number: 10555948
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 11, 2020
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
  • Patent number: 10442868
    Abstract: The specification provides compositions and methods of reducing a risk of a HBV infection in a subject and of treating a subject infected with HBV.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 15, 2019
    Assignee: Rhode Island Hospital, A Lifespan-Partner
    Inventors: Jack R. Wands, Jisu Li, Shuping Tong
  • Patent number: 10364440
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: July 30, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Thomas J. Webster, Qian Chen, Yupeng Chen, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10352933
    Abstract: Detection and quantification of microbial colonization and biofilm formation on orthopedic explants would be important for deciding treatment interventions at the time of surgery. Methods and Systems for such treatments are shown that utilize various steps and kits to quickly generate confocal laser-scanning microscopy (CLSM) images to allow for the detection and quantification. The explants are prepared by applying antibodies of both gram-positive and grain-negative for at least one period of time.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: July 16, 2019
    Assignee: Rhode Island Hospital
    Inventors: Dioscaris Garcia, Christopher T. Born, John Jarrell
  • Patent number: 10344300
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: July 9, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Yunpeng Chen, Qian Chen, Thomas J. Webster, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10286041
    Abstract: Provided herein are methods for prophylactic treatment of renal disorders comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual suspected of having, predisposed to, or at risk of developing a renal disorder.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: May 14, 2019
    Assignees: Mallinckrodt ARD IP Limited, Rhode Island Hospital
    Inventors: Steve Cartt, Rujun Gong
  • Publication number: 20190134269
    Abstract: Methods and devices for the repair of a torn or injured ligament or tendon are provided. The methods include the use of multiple scaffolds, e.g., beads. The multiple scaffolds may be positioned along a suture or other device such that they are moveable with respect to one another or the injured tissue.
    Type: Application
    Filed: July 6, 2017
    Publication date: May 9, 2019
    Applicants: Children's Medical Center Corporation, Rhode Island Hospital
    Inventors: Martha M. Murray, Braden C. Fleming
  • Patent number: 10272145
    Abstract: The invention provides compositions and methods for preventing or reducing the severity of malaria.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: April 30, 2019
    Assignees: Rhode Island Hospital, Seattle Biomedical Research Institute
    Inventors: Jonathan Kurtis, Christian Parcher Nixon, Dipak Kumar Raj, Jennifer Frances Friedman, Michal Fried, Patrick Emmet Duffy
  • Patent number: 10213502
    Abstract: The invention provides compositions and methods for preventing or reducing the severity of malaria.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 26, 2019
    Assignees: Rhode Island Hospital, Seattle Biomedical Research Institute
    Inventors: Jonathan Kurtis, Christian Parcher Nixon, Dipak Kumar Raj, Jennifer Frances Friedman, Michal Fried, Patrick Emmet Duffy
  • Publication number: 20190054048
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as Sa bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Application
    Filed: September 23, 2016
    Publication date: February 21, 2019
    Applicants: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn FUCHS, Eleftherios MYLONAKIS, Frederick M. AUSUBEL, Raj Mohan Raja MUTHIAH, Wooseong KIM
  • Patent number: 10130687
    Abstract: Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 20, 2018
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Chathuraka T. Jayasuriya
  • Patent number: 9921230
    Abstract: This invention relates to compositions and methods for diagnosing and treating concussion/mTBI.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: March 20, 2018
    Assignee: Rhode Island Hospital
    Inventors: Adam Chodobski, Joanna Szmydynger-Chodobska
  • Publication number: 20180015141
    Abstract: Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-?B translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
    Type: Application
    Filed: January 26, 2016
    Publication date: January 18, 2018
    Applicant: Rhode Island Hospital, A Lifespan Partner
    Inventors: Gregory D. Jay, Benjamin D. Sullivan, Tannin Avery Schmidt, Khaled Elsaid, Edward R. Truitt, Roman Krawetz, Joanna Szmydynger-Chodobska, Adam Chodobska, Jawed Fareed
  • Patent number: 9833446
    Abstract: A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog pathway inhibitor such as a Smoothened inhibitor.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 5, 2017
    Assignees: Rhode Island Hospital, University Health Network
    Inventors: Wentian Yang, Benjamin G. Neel