Patents Assigned to Rhode Island Hospital, A Lifespan Partner
  • Publication number: 20190054048
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as Sa bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Application
    Filed: September 23, 2016
    Publication date: February 21, 2019
    Applicants: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn FUCHS, Eleftherios MYLONAKIS, Frederick M. AUSUBEL, Raj Mohan Raja MUTHIAH, Wooseong KIM
  • Publication number: 20180015141
    Abstract: Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-?B translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
    Type: Application
    Filed: January 26, 2016
    Publication date: January 18, 2018
    Applicant: Rhode Island Hospital, A Lifespan Partner
    Inventors: Gregory D. Jay, Benjamin D. Sullivan, Tannin Avery Schmidt, Khaled Elsaid, Edward R. Truitt, Roman Krawetz, Joanna Szmydynger-Chodobska, Adam Chodobska, Jawed Fareed
  • Patent number: 9784743
    Abstract: The specification provides methods of determining whether a subject suffering from ER+/HER2+ breast cancer is likely to respond to adjuvant and neoadjuvant chemotherapy and methods of treating a subject suffering from ER+/HER2+ breast cancer.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: October 10, 2017
    Assignee: Rhode Island Hospital, A Lifespan-Partner
    Inventors: Alexander S. Brodsky, Yihong Wang, Murray Resnick
  • Patent number: 9522943
    Abstract: Methods and compositions for determining a prognosis for a subject infected with HIV, reducing a risk of an HIV infection, and treating or reducing a risk of developing AIDS are described.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: December 20, 2016
    Assignee: Rhode Island Hospital, A Lifespan-Partner
    Inventors: Michelle Lally, Bharat Ramratnam, Ming Li
  • Publication number: 20130116186
    Abstract: Disclosed are novel methods of maintaining articular cartilage health in an atraumatic, non-diseased joint of a mammal, either human or non-human. The methods involve injecting into the joint capsule of the mammal an amount of a lubricin polypeptide to prevent shear-induced chondrocyte apoptosis and to maintain a lubricin-expressing phenotype of chondrocytes.
    Type: Application
    Filed: October 4, 2012
    Publication date: May 9, 2013
    Applicant: Rhode Island Hospital, A Lifespan Partner
    Inventor: Rhode Island Hospital, A Lifespan Partner
  • Patent number: 7935528
    Abstract: The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 3, 2011
    Assignee: Rhode Island Hospital, a Lifespan Partner
    Inventor: Ronald A. Faris
  • Patent number: 7867705
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: January 11, 2011
    Assignee: Rhode Island Hospital, a Lifespan-Partner
    Inventors: Jack R. Wands, Philippe Merle, Suzanne M. De La Monte
  • Publication number: 20100203054
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins and genes, and Wnt- and FZD-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Application
    Filed: February 5, 2010
    Publication date: August 12, 2010
    Applicant: RHODE ISLAND HOSPITAL, A LIFESPAN-PARTNER
    Inventors: Jack R. Wands, Miran Kim
  • Patent number: 7415381
    Abstract: A system for determining an indication of animal joint mobility includes a mounting apparatus configured to hold a first condyle of the joint stationary in a position such that a second condyle of the joint can pivot about the joint, a pendulum configured to be coupled to the second condyle and configured such that a portion of a weight of the pendulum is disposed below a pivot axis of the joint such that the pendulum and second condyle can oscillate about the pivot axis, an angular displacement indicator associated with the pendulum, an angular displacement recorder configured to store indicia of the angular displacement, as indicated by the angular displacement indicator; of the pendulum over time, and a processor coupled to the angular displacement recorder and configured to use the angular displacement indicia to determine a first value associated with momentum decay of oscillations of the pendulum and to use the at least one value to determine a second value associated with a coefficient of friction of t
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: August 19, 2008
    Assignee: Rhode Island Hospital, A LifeSpan Partner
    Inventor: Gregory D. Jay
  • Patent number: 6960562
    Abstract: The invention features a lubricating polyeptide and methods of lubricating joints or other tissues by administering the polypeptide systemically or directly to tissues.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: November 1, 2005
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventor: Gregory D. Jay
  • Patent number: 6521616
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: February 18, 2003
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Patent number: 6489128
    Abstract: A method for diagnosing a tumor in the central nervous system of a mammal is carried out by contacting a bodily fluid from the mammal with a ligand which binds to inter-alpha trypsin inhibitor.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: December 3, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Yow-Pin Lim, Douglas C. Hixson
  • Patent number: 6429224
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: August 6, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Patent number: 6129911
    Abstract: The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: October 10, 2000
    Assignee: Rhode Island Hospital, A LifeSpan Partner
    Inventor: Ronald A. Faris