Patents Assigned to Rhone-Poulenc Rorer S.A.
  • Patent number: 6013662
    Abstract: Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or elsea ##STR2## radical, R.sub.1 and R.sub.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: January 11, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commer.cedilla.on, Norbert Dereu, Patrick Mailliet, Fabienne Sounigo-Thompson, Jean-Paul Martin, Marc Capet, Michel Cheve
  • Patent number: 6008385
    Abstract: A method for purifying taxoids (Taxotere, 10-deacetylbaccatin III) by centrifugal partition chromatography.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: December 28, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Andre Durand, Alain Gerbaud, Rodolphe Margraff
  • Patent number: 6001631
    Abstract: A novel topoisomerase IV, nucleotide sequences coding for said enzyme, corresponding vectors, and the use of said enzyme for screening biologically active materials.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: December 14, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Alain Famechon, Lucia Ferrero
  • Patent number: 6002022
    Abstract: A process for the preparation of 4,10-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.-dihydroxy-9- oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate by crystallization from a water/alcohol solution.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: December 14, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Rene Authelin, Eric Didier, Franck Leveiller, Isabelle Taillepied
  • Patent number: 5994299
    Abstract: Cyclosporin compounds of formula (I): ##STR1## wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are useful in the treatment and/or prophylaxis of retrovirus infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: November 30, 1999
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Jean-Claude Barriere, Georges Bashiardes, Jean-Christophe Carry, Michel Evers, Bruno Filoche, Serge Mignani
  • Patent number: 5994338
    Abstract: A stabilized pharmaceutical composition having a combined quinupristine/dalfopristine base and containing an at least stoichiometric amount of methanesulphonic acid or hydrochloric acid and being characterized in that its pH ranges from about 3.5 to about 5. Methods of making and using the stabilized composition are also disclosed.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: November 30, 1999
    Assignee: Rhone Poulenc Rorer S.A.
    Inventors: Jean-Paul Bounine, Guillaume Conrath
  • Patent number: 5990108
    Abstract: Compounds of formula (I), wherein R is a hydrogen atom or a --COOH, -alk-COOH, --PO.sub.3 H.sub.2, --CH.sub.2 --PO.sub.3 H.sub.2, or --CH.dbd.CH--COOH radical, or a phenyl radical substituted by a carboxy radical, R.sub.1 is an alk-CN, -alk-COOH, -alk-Het, alk-PO.sub.3 H.sub.2 or -alk-CO--NH--SO.sub.2 R.sub.2 radical, R.sub.2 is an alkyl or phenyl radical, alk is an alkyl radical, Het is a saturated or unsaturated mono- or polycyclic heterocyclic ring containing 1-9 carbon atoms and one or more heteroatoms selected from O, S and N, said heterocyclic ring optionally being substituted by one or more alkyl, phenyl or phenylalkyl radicals, with the proviso that when R is a hydrogen atom or a --COOH or --PO.sub.3 H.sub.2 radical, R.sub.1 cannot be -alk-COOH, isomers, racemic mixtures, enantiomers and diastereoisomers thereof, salts thereof, the preparation thereof, intermediates thereof and drugs containing said compounds, are disclosed.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: November 23, 1999
    Assignee: Rhone Poulenc Rorer S.A.
    Inventors: Jean-Claude Aloup, Jean Bouquerel, Dominique Damour, Jean-Claude Hardy, Patrick Jimonet, Franco Manfre, Serge Mignani, Patrick Nemecek
  • Patent number: 5977375
    Abstract: A compound of the formula I: ##STR1## wherein Ar represents an aryl radical;R.sub.1 represents a hydrogen atom, an aroyl radical, or a radical of the formula R.sub.4 --O--CO;R.sub.2 and R.sub.3 together form a 5- or 6-membered saturated heterocycle;G.sub.1 represents an acetyl radical or a protecting group of the hydroxyl functional group; andG.sub.2 represents a protecting group of the hydroxyl functional group.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: November 2, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Noel Denis, Andrew-Elliot Greene, Jean-Manuel Mas
  • Patent number: 5977067
    Abstract: Cyclosporin derivatives of formula (I) in which R is H or a radical (Ia) or (Ib) as defined herein; R' is a radical (Ic) or (Id) as defined herein; and R"represents H or OH, with the proviso that R and R" are not simultaneously H, and pharmaceutically acceptable salts thereof, when they exist, are disclosed as useful for the treatment and/or prophylaxis of retrovirus infections.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Michel Evers, Serge Mignani, Jean-Christophe Carry, Bruno Filoche, Georges Bashiardes, Claude Bensoussan, Jean-Christophe Gueguen, Jean-Claude Barriere
  • Patent number: 5972342
    Abstract: The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: October 26, 1999
    Assignees: Rhone-Poulenc Rorer S.A., Institute Malgache De Recherches Appliquees
    Inventors: Albert Rakoto Ratsimamanga, Suzanne Rakoto Ratsimamanga, Philippe Rasoanaivo, Jean Leboul, Jean Provost, Daniel Reisdorf
  • Patent number: 5969179
    Abstract: A process for preparing an enantiomeric form of 2-amino-3-(4-alkylaminophenyl)-propanoic acid of formula (I) or a salt thereof: ##STR1## in which Alk represents an alkyl radical containing 1 to 2 carbon atoms, from (L)-phenylalanine to obtain the (S)-enantiomer of 2-amino-3-(4-alkylaminophenyl)-propanoic acid, or from (D)-phenylalanine to obtain the (R)-enantiomer of 2-amino-3-(4-alkylaminophenyl)propanoic acid.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: October 19, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Robert Stammler
  • Patent number: 5968931
    Abstract: Novel taxoids of general formula (I), the preparation thereof, and pharmaceutical compositions containing the novel taxoids: ##STR1## wherein Z represents a hydrogen atom or a radical of general formula (II): ##STR2##
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: October 19, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Bouchard, Alain Commer.cedilla.on
  • Patent number: 5965527
    Abstract: A cyclosporin compound of the formula (I): ##STR1## wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are is useful in the treatment and/or prophylaxis of retrovirus infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: October 12, 1999
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Jean-Claude Barriere, Georges Bashiardes, Jean-Christophe Carry, Michel Evers, Bruno Filoche, Jean-Pierre Leconte, Serge Mignani
  • Patent number: 5962705
    Abstract: The present invention relates to a novel process for preparing dialkoxy derivatives of the taxoid family by direct alkylation of the two positions 7 and 10 of deacetylbaccatin or derivatives thereof which are esterified in position 13.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: October 5, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Eric Didier, Gilles Oddon, Denis Pauze, Patrick Leon, Didier Riguet
  • Patent number: 5959125
    Abstract: Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or an alkenyl, alkynyl, cycloalkyl, optionally substituted cycloalkenyl or phenyl radical, or an aromatic 5- or 6-membered heterocyclic radical; and Z is a hydrogen atom or a radical of general formula (II), wherein R.sub.1 is an optionally substituted benzoyl, thenoyl or furoyl radical or a radical R.sub.2 --O--CO, where R.sub.2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl, or heterocycl radical, and R.sub.3 is an aromatic heterocyclic, alkyl, alkenyl, alkynyl cycloalkyl, phenyl or naphthyl radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral activity.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: September 28, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Herve Bouchard, Jean-Dominique Bourzat, Alain Commer.cedilla.on
  • Patent number: 5948755
    Abstract: The cyclosporin compound of formula (I) is particularly useful in the treatment and/or prophylaxis of retrovirus infections.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: September 7, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Claude Barriere, Georges Bashiardes, Jean-Christophe Carry, Michel Evers, Bruno Filoche, Serge Mignani
  • Patent number: 5935980
    Abstract: The use of pyrrolidine derivatives of general formula (I) for treating chronic alcoholism or conditions caused by alcohol abuse is described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: August 10, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventor: Assunta Imperato
  • Patent number: 5936097
    Abstract: Novel products of formula (I): ##STR1## preparation thereof and pharmaceutical compositions containing said products are disclosed. In formula (I), R is a group of formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z, where X.sub.1 is a simple bond or O or S, n is 0 or 1 and n is 0, 1 or 2, the CH.sub.2 groups being optionally substituted by carboxy, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, amino, alkylamino or dialkylamino, and Z is carboxy, COOR.sub.4, where R.sub.4 is alkyl, or CON(R.sub.5)(R.sub.6), where R.sub.5 hydrogen or alkyl and R.sub.6 is hydrogen or optionally substituted alkyl, or else R.sub.5 is hydrogen or alkyl and R.sub.6 is hydroxy, optionally substituted alkoxy or amino, or PO(OR.sub.7).sub.2, where R.sub.7 is hydrogen or alkyl; or a group --NH--CO--T where T is hydrogen or optionally substituted alkyl; or else a group (a); R.sub.1 and R.sub.2 are hydrogen or halogen or optionally substituted alkyloxy or alkyl, or else R.sub.1 and R.sub.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: August 10, 1999
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Alain Commer.cedilla.on, Alain Le Brun, Patrick Mailliet, Jean-Fran.cedilla.ois Peyronel, Fabienne Sounigo-Thompson, Alain Truchon, Martine Zucco
  • Patent number: 5922716
    Abstract: Compounds of formula (I): ##STR1## wherein R represents a CR.sub.4 R.sub.5, CHR.sub.6, or C.dbd.R.sub.7 radical and R.sub.3 represents an oxygen atom, salts thereof, the preparation thereof and drugs containing same. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-osoxaziepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: July 13, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Claude Aloup, Fran.cedilla.ois Audiau, Michel Barreau, Dominique Damour, Arielle Genevois-Borella, Patrick Jimonet, Serge Mignani, Yves Ribeill
  • Patent number: 5908835
    Abstract: Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than the expected additive effect of its individual components.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: June 1, 1999
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventor: Marie-Christine Bissery