Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.

Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Abstract: An optical test strip (118) for measuring an analyte concentration in a sample of bodily fluid is disclosed.

Abstract: Methods are provided for correcting an analyte concentration measurement that may be influenced by hematocrit (HCT), especially a glucose concentration measurement. The methods include determining by means of a reference instrument a HCT reference value of a reference blood sample taken from a specific user, applying a fresh blood sample of the user on a disposable analytical test element, measuring the glucose value of the fresh blood sample by single use of the test element in a glucose meter, determining a HCT correction value using at least the HCT reference value, and adjusting the measured glucose value using the HCT correction value to receive an adjusted glucose value. Also provided are devices and system incorporating or for performing the methods.

Abstract: A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt).

Abstract: A sensor assembly (256) for detecting at least one analyte in a body fluid and a method of assembly a sensor assembly (256) for detecting at least one analyte in a body fluid are disclosed. The sensor assembly (256) comprises: at least one body mount (212) configured for attachment to a body of a user; at least one electronics unit (186) attachable to the body mount (212), having at least one electronics component (208) for one or more of controlling the detection of the analyte or transmitting measurement data to another component; wherein the body mount (212) includes a locking mechanism (216) having at least one lever (218) pivotably mounted to the body mount (212), the lever (218) being configured to lock the electronics unit (186) to the body mount (212).

Abstract: The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.

Abstract: Disclosed is septum arrangement having a pierceable septum. The pierceable septum has first and second surfaces positioned opposite to one another and a peripheral surface. A compression element has at least two compression members that partially or fully surround the peripheral surface and has at least two gripping members. Each compression member is connected to at least one gripping member, and the gripping members extend from the compression members towards a common axis (A) which intersects the first surface. A resilient element exerts a biasing force on the pierceable septum that is directed towards the common axis (A). The gripping members define an aperture between them such that introduction of a needle into the aperture exerts a force on the gripping members that counteracts the biasing force and moves the gripping members apart from each other.

Abstract: The invention relates to a drug delivery system for a patient comprising an insulin delivery device (100), a user interface (101), a controller (109) comprising instructions and a user definable threshold criterion (114; 116) of a residual availability of a drug provided in a reservoir (102) of the drug delivery system, wherein executing of the instructions by the controller (109) causes the controller (109) to control the drug delivery system to determine the amount of the drug that is currently available to the patient and compare the determined amount with the threshold criterion (114; 116), in response to the comparison, in case the determined amount is lower than or equal to the threshold criterion (114; 116), providing a signal to the patient via the user interface (101). The drug is insulin.

Abstract: A method for evaluating the suitability of a mobile device having a camera for performing an analytical measurement based on a color formation reaction. A mobile device is provided and is used to take an image of a reference color field of an object. A color coordinate of pixels of a region of interest within the image is determined and a histogram analysis is performed on a distribution of the color coordinates of the pixels. The width of a color peak within the distribution from the histogram analysis is ascertained and compared with a threshold value to thereby determine suitability of the mobile device for performing the analytical measurement based on the color formation reaction.

Abstract: A handheld display device for processing continuous sensor data has a communication interface, a graphical user interface having a gesture recognition component, a processor and a memory. The processor continuously receives time dependent sensor data, carbohydrate data, event data, and insulin data. The event data is indicative of a physical state of the subject. The processor determines a sensor data scaling factor, a carbohydrate data scaling factor and an insulin data scaling factor. The processor controls the graphical user interface to render a plot having single time, analyte concentration, carbohydrate amount, and insulin delivery amount axes. The analyte concentration axis is rendered on a first side of the plot and carbohydrate amount and insulin delivery amount axes are rendered on an opposite side of the plot, according to the scaling factors. The graphical user interface can be controlled with single and/or double finger gestures to magnify, shrink or shift axes.

Abstract: Embodiments of the present invention are directed to devices, systems and methods for delivering therapeutic fluid (e.g., insulin) into the body, including a skin adherable cradle, for retaining a therapeutic fluid dispenser for delivering a therapeutic fluid to a user.

Abstract: A lock mechanism for a compartment has been developed. The lock mechanism includes a deformable arm affixed to a housing of the compartment and positioned within the compartment. The deformable arm includes a first end configured to be biased into a first position to engage a latch of a door of the compartment to prevent the latch from opening, and a receiving surface configured to receive an external force to move the deformable arm to a second position that disengages the first end from the latch to enable opening of the latch while the external force is applied to the receiving surface.

Abstract: An alert is used to inform a user that their blood glucose level has dropped below a threshold (e.g., the user is hypoglycemic) or has increased above a threshold (e.g., the user is hyperglycemic). There is a hierarchy of alerts from lowest priority to highest priority. The alert is communicated by a user device (e.g., a mobile device), which is, for example, a smartphone, smart watch, home automation device, or the like. The alert is modified in order to increase the likelihood that the user receives or acknowledges the alert within a minimal amount of time. An intensity level (e.g., a volume) of an alert is modified based on, for example, whether the user has acknowledged a previous alert. A modality or a sensory channel of an alert is changed if an initial alert does fails to elicit a response from the user.

Abstract: The application concerns a stickpack-type packaging comprising an elongate foil tube (12) having two transverse sealing joints (16,18), such that a tightly closed fill space (20) is provided in the foil tube (12) for storing a product. It is proposed that a single disposable test strip (22) is arranged in the fill space (20), wherein the test strip (22) has a chemistry pad (26) for detecting an analyte in a sample, and the chemistry pad (26) is arranged at a distance at least from one of the transverse sealing joints (16,18).

Abstract: The invention relates to a device (100) for performing at least one medical action at a human or animal body; wherein the device (100) comprises an energy source (107) and a computer (103); wherein the computer (103) a) comprises a first erasable non-volatile memory (104), and b) is configured for performing at least one application, the application being configured i) to control the medical action, and ii) to prioritize the medical action over a memory cleaning called by a wear leveling. Furthermore, the invention relates to a process, comprising operating the device (100) in consecutive cycles or tasks; to a use of a wear leveling algorithm and a prioritizing algorithm; and to a use of the device (100) in a treatment of a diabetes mellitus.

Abstract: An optical test strip (110), a method and a kit (128) for measuring an analyte concentration in a sample (112) of bodily fluid are disclosed.

Abstract: Methods are provided for correcting an analyte concentration measurement that may be influenced by hematocrit (HCT), especially a glucose concentration measurement. The methods include determining by means of a reference instrument a HCT reference value of a reference blood sample taken from a specific user, applying a fresh blood sample of the user on a disposable analytical test element, measuring the glucose value of the fresh blood sample by single use of the test element in a glucose meter, determining a HCT correction value using at least the HCT reference value, and adjusting the measured glucose value using the HCT correction value to receive an adjusted glucose value. Also provided are devices and system incorporating or for performing the methods.

Abstract: A method is provided for verifying test element integrity includes providing a biosensor having an electrode-support substrate. A first electrode is provided on the substrate that includes a first body and a neck extending from the first body. A second electrode is provided on the substrate that includes a second body and an opposite pair of necks. Each of the necks extends from a respective end of the second body. A spacer is positioned on the substrate and has an edge defining a boundary of a capillary channel formed between a cover and the substrate. The method also includes applying a signal across the necks of the second electrode to verify continuity along the second electrode. The second body of the second electrode and the pair of connective necks surround the first electrode in the capillary channel forming a loop circuit around the first electrode.

Abstract: A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.