Patents Assigned to Roche Molecular System, Inc.
  • Patent number: 11181449
    Abstract: The subject disclosure presents systems and methods for improved meso-dissection of biological specimens and tissue slides including importing one or more reference slides with annotations, using inter-marker registration algorithms to automatically map the annotations to an image of a milling slide, and dissecting the annotated tissue from the selected regions in the milling slide for analysis, while concurrently tracking the data and analysis using unique identifiers such as bar codes.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: November 23, 2021
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Barnes, Christophe Chefd'hotel, Srinivas Chukka, Mohammad Qadri
  • Patent number: 11156508
    Abstract: The present invention provides improved methods that allow accurate monitoring and/or control of temperature changes in a microfluidic environment. An advantage of the present invention is that the temperature can be monitored and/or controlled at any location within a microfluidic device, especially where a preparation step, an amplification step and/or a detection step is performed. The invention further provides improved microfluidic devices for practicing the methods disclosed and claimed herein.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hamed Shadpour, Sean Ford, Jorge Alberto Garces, Darren S. Gray
  • Patent number: 11156605
    Abstract: The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical detection schemes.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Michael Leonard Wood, Aviva Ruth Jacobs
  • Patent number: 11155886
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus and kits are provided that are designed for the detection of Zika virus.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Slav Dugenny, Ellen H Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun
  • Patent number: 11155852
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Patent number: 11149319
    Abstract: Accurate measurements of the presence or absence of a target cell in a sample are provided. For example, the sample can be mixed with a plurality of transduction particles capable of binding to the target cells, the transduction particles being engineered to include a nucleic acid molecule formulated to cause the target cells to produce a plurality of detectable reporter molecules once the particles bind to and deliver the nucleic acid molecules into the one or more target cells. A set of signal data points are received that are associated with a quantity of reporter molecules and the signal data points are analyzed to accurately detect target cells in the sample. Systems and methods are disclosed.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: October 19, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Corey Hoeppner, Ronald T Kurnik, Xianxian Liu, Soni Shukla
  • Patent number: 11124840
    Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 21, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Rajiv Dua, Marcel Fontecha, Yan Li, Wei-min Liu, Christopher Santini, Lori Steiner, Yu Chuan Tai
  • Patent number: 11125660
    Abstract: The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case, and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 21, 2021
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Barnes, Srinivas Chukka, Mohammad Qadri
  • Patent number: 11078534
    Abstract: The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside triphosphates. The present invention also provides for methods for using the modified nucleoside triphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: August 3, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alexander Nierth, Hannes Kuchelmeister, Concordio Anacleto, Amar Gupta, Dieter Heindl, Igor Kozlov, Christian Wellner, Stephen Gordon Will
  • Patent number: 11077444
    Abstract: Package assemblies for storing diagnostic cartridges or storing wet/dry reagents are described herein. In some embodiments, an apparatus includes a tray member defining a first volume and a second volume, and a cover member coupled to the tray member covering the first volume and the second volume. The tray member includes a central portion that separates the first volume from the second volume. The first volume is configured to receive a desiccant package and a sample container containing a first reagent. The first reagent has a solid form. The second volume is configured to receive a reagent module containing a second reagent. The second reagent has a liquid form. The cover member and the central portion of the tray member are configured to isolate the first volume from the second volume.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: August 3, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Doran Donnelly, Travis Wong
  • Patent number: 11067565
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: July 20, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Patent number: 11052484
    Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 6, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
  • Publication number: 20210178398
    Abstract: The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 17, 2021
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Lawrence Chiu, Ion Iordanoaia, Reiner Hitt, Vijay Namasivayam, Eduard Nawrocki, Michael Neugebauer, Tim Moulton, Sam Palmer, Gerd Schmieta
  • Publication number: 20210181218
    Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 17, 2021
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Andreas Gisler, Mike Mohns, Vijay Namasivayam, Maren Christin Wolff, Devorah Klein, Tim Moulton, Sam Palmer, Eric Saperstein
  • Publication number: 20210181074
    Abstract: Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
    Type: Application
    Filed: November 12, 2020
    Publication date: June 17, 2021
    Applicant: Roche Molecular Systems, Inc
    Inventors: Nils B. Adey, Katherine B. Geiersbach, Mark Herrmann, Robert J. Parry
  • Patent number: 11034997
    Abstract: The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 15, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Igor Kozlov, Amar Gupta, Randall Saiki, Alison Tsan
  • Patent number: 11028433
    Abstract: The present invention describes methods for performing higher multiplexed PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 8, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Igor Kozlov, Amar Gupta, Randall Saiki, Alison Tsan
  • Patent number: 11031099
    Abstract: Systems, methods, and apparatuses are provided for detecting nucleic acid sequence variants. Other embodiments are directed to systems and computer readable media associated with methods described herein.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: June 8, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Christina Bormann Chung
  • Patent number: D930022
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: September 7, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Qianwei Xie, Marc Mailman, Vishakha Sharma, Veronica Nemmer, Elizabeth Little, Wojciech Kaczmarek, Maciej Chmielarski, Tomasz Sciurka, Szymon Dolata, Maciej Laskowski
  • Patent number: D931314
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: September 21, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Qianwei Xie, Marc Mailman, Vishakha Sharma, Veronica Nemmer, Elizabeth Little, Wojciech Kaczmarek, Maciej Chmielarski, Tomasz Sciurka, Szymon Dolata, Maciej Laskowski