Patents Assigned to Roussel-UCLAF
  • Patent number: 5811444
    Abstract: The invention relates to the new use and the new products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all the isomer forms and the salts, as medicaments.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 22, 1998
    Assignee: Roussel Uclaf
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5807878
    Abstract: A compound of the formula ##STR1## wherein the substituents are defined in the specification useful for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: September 15, 1998
    Assignee: Roussel Uclaf
    Inventors: Alain Corbier, Pierre Deprez, Michel Fortin, Jacques Guillaume, Bertrand Heckmann
  • Patent number: 5798231
    Abstract: The present invention relates to new nucleotide sequences coding for variable regions of the .alpha. chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: August 25, 1998
    Assignee: Roussel Uclaf
    Inventors: Thierry Hercend, Frederic Triebel, Sergio Roman-Roman, Laurent Ferradini
  • Patent number: 5795982
    Abstract: A compound having a formula selected from ##STR1## wherein A and B are selected from the group consisting of ##STR2## K and K' are selected from the group consisting of ##STR3## n is 2 or 3 and R.sub.1 is an ether or ester residue.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: August 18, 1998
    Assignee: Roussel Uclaf
    Inventors: Catherine Geurts, Michel Vivat
  • Patent number: 5792859
    Abstract: Novel intermediate compounds of formula IV, V, VI, VII and VIII which are useful for the preparation of steroids of the formula ##STR1## wherein the substituents are defined in the specification.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: August 11, 1998
    Assignee: Roussel Uclaf
    Inventors: Robert Lett, Oleg Melnyk
  • Patent number: 5788980
    Abstract: An intravaginal drug delivery device for prolonged release of an active ingredient comprising a biocompatible polymer matrix containing an active ingredient to be released and an effective amount of at least one fatty acid ester and a method of inducing contraception in female warm-blooded animals, including humans.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: August 4, 1998
    Assignee: Roussel Uclaf
    Inventor: Shohre Nabahi
  • Patent number: 5786339
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R and R.sub.1 are --OH or --O-acyl of an organic carboxylic acid of 2 to 20 carbon atoms, R.sub.2 is hydrogen or methyl, R.sub.3 is --(CH.sub.2).sub.m --R.sub.4 or ##STR2## or --N--(CH.sub.2).sub.q --R.sub.4, m is an integer from 1 to 6, n, p and q are individually an integer from 0 to 6, A and B are individually selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms with the geometry of the double bond being E or Z or a mixture of E and Z or A and B form a triple bond, R.sub.4 is an optionally substituted mono- or polycyclic heterocycle and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.
    Type: Grant
    Filed: November 30, 1995
    Date of Patent: July 28, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Jean-Fran.cedilla.ois Chantot
  • Patent number: 5770579
    Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', b is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: June 23, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
  • Patent number: 5770748
    Abstract: A novel process for the preparation of oxoetiocholenic acid of the formula ##STR1## and intermediates therefore.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: June 23, 1998
    Assignee: Roussel Uclaf
    Inventors: Patrick Roussel, Michel Vivat
  • Patent number: 5770192
    Abstract: A recombinant baculovirus which, in insect cells infected therewith, expresses a foreign protein comprising an insecticidal toxin, or a functional derivative thereof, provided with a signal peptide such that the toxin or derivative thereof is secreted from the insect cells. This recombinant baculovirus can be used in insect control.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: June 23, 1998
    Assignees: Roussel-Uclaf, Natural Environment Research Council
    Inventors: Patricia Jane Cayley, Lorna Mary Dyet Stewart, Robert David Possee, Miguel Lopez Ferber
  • Patent number: 5763617
    Abstract: A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an integral salt or their salts with organic or mineral acids wherein the substituents are as defined in the application and having antibacterial properties.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: June 9, 1998
    Assignee: Roussel Uclaf
    Inventors: Jozsef Aszodi, Jean-Francois Chantot, Patrick Fauveau, Solange Gouin D'Ambrieres, Daniel Humbert, Christophe Dini
  • Patent number: 5759801
    Abstract: A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of transformed yeasts and uses thereof.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: June 2, 1998
    Assignee: Roussel Uclaf
    Inventors: Xavier Chenivesse, Catherine Duport, Eric Lecain, Denis Pompon
  • Patent number: 5760233
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: June 2, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5760256
    Abstract: A process for the production of a compound of the formula ##STR1## wherein R.sub.1 is acyl of 1 to 8 carbon atoms,. The compound is formed by the reduction of an intermediary to form an alcohol, epoxidation and hydrolyzation of the alcohol to form a compound of formula ##STR2## followed by the acylation of the hydroxy functions and the elimination of the 17.alpha.-substituent.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: June 2, 1998
    Assignee: Roussel Uclaf
    Inventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
  • Patent number: 5756722
    Abstract: The novel intermediates of the formula ##STR1## wherein L, K and M are as defined in the specification which are useful intermediates for the preparation of .DELTA..sup.4,9(11),16 -pregnatriene-3-ones.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: May 26, 1998
    Assignee: Roussel Uclaf
    Inventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
  • Patent number: 5750553
    Abstract: A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula ##STR1## wherein Y is --O--, Z.sub.2 is --CF.sub.3, Z.sub.1 is --CN or --NO.sub.2, X is --O-- or --S--, R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or --CN and R.sub.4 and R.sub.5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, --OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or --OH, and wherein at least one of R.sub.4 and R.sub.5 is substituted having antiandrogenic activity.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: May 12, 1998
    Assignee: Roussel Uclaf
    Inventors: Andre Claussner, Francois Goubet, Jean Teutsch
  • Patent number: 5747467
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein X is selected from the group consisting of --(NH).sub.a --, --CH.sub.2 --, --SO.sub.2 -- and --O--, a is 0 or 1, Y is --(CH.sub.2).sub.m - (CH.dbd.CH).sub.n --(CH.sub.2).sub.o -, m+n+o.ltoreq.8, n=o or 1, Ar is aryl optionally substituted with at least one member of the group consisting of --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, -N-alkyl, -N-alkenyl and N-alkynyl of up to 12 carbon atoms, R.sub.a and R.sub.b individually are hydrogen or alkyl of up to 12 carbon atoms, R.sub.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: May 5, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Fran.cedilla.ois Bretin, Jean-Fran.cedilla.ois Chantot
  • Patent number: 5744635
    Abstract: A method for prerparing compounds of formula (I), wherein R is an optionally substituted alkenyl or alkynyl radical having up to 8 carbon atoms, or an optionally substituted mono- or polycyclic aryl or heteroaryl radical, and R.sub.1 and R.sub.2 are an alkyl radical having up to 4 carbon atoms. According to the method, a compound of the formula (II), wherein X is a halogen atom, is exposed to an organometallic compound of the formula (III): RZ, wherein R has the same meaning as before and Z is a metal or metal derivative. Alternatively, a compound of formula (II'), wherein Z' is a metal or metal derivative, is exposed to a compound of the formula (III'): RX', wherein X' is a nucleophilic reaction leaving group.
    Type: Grant
    Filed: October 3, 1995
    Date of Patent: April 28, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean-Louis Brayer, David Michael Hodgson, Ian Christopher Richards, Jason Witherington
  • Patent number: 5739124
    Abstract: A method of controlling male fertility in warm-blooded animals comprising vaginally administering to female warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of alkyl of 1 to 8 carbon atoms and benzyl or taken together with the nitrogen form a saturated 5 to 6 ring heterocycle optionally containing a second nitrogen or oxygen in the ring, R.sub.3 is .alpha.- or .beta.-methyl, n is an integer from 2 to 10; R.sub.4 and R.sub.5 together are =0 or R.sub.4 is selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms and R.sub.5 is selected from hydrogen, --OH, acyloxy of an organic acid of up to 12 carbon atoms and alkyl, alkenyl and, alkynyl of up to 8 carbon atoms, R.sub.6 and R.sub.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: April 14, 1998
    Assignee: Roussel Uclaf
    Inventors: Armelle Bonfils, Daniel Philibert
  • Patent number: 5731447
    Abstract: A process for the preparation of a compound of the formula ##STR1##
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: March 24, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean Buendia, Patrick Roussel, Michel Vivat