Patents Assigned to Salk Institute for Biological Studies
  • HIGH-EFFICIENCY RECONSTITUTION OF RNA MOLECULES
    Publication number: 20220145347
    Abstract: Provided herein are synthetic RNA molecules for reconstitution of RNA molecules, including compositions and methods of using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a therapeutic protein, for example to treat a genetic disease or cancer.
    Type: Application
    Filed: September 27, 2021
    Publication date: May 12, 2022
    Applicant: Salk Institute for Biological Studies
    Inventors: Lukas Christoph Bachmann, Samuel Lawrence Pfaff
  • RNA targeting methods and compositions
    Patent number: 11316812
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 26, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA targeting methods and compositions
    Patent number: 11310179
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 19, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA targeting methods and compositions
    Patent number: 11310180
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 19, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA targeting methods and compositions
    Patent number: 11303594
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 12, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA targeting methods and compositions
    Patent number: 11303592
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 12, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA targeting methods and compositions
    Patent number: 11303593
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: April 12, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • ONCOLYTIC ADENOVIRUS COMPOSITIONS
    Publication number: 20220096577
    Abstract: An adenovirus comprising an E1A polypeptide comprising one or more modifications and comprising an E4orf6/7 polypeptide comprising one or more modifications is described. Compositions and kits comprising the modified adenoviruses are also described. Further described is a method of treating a proliferative disorder in a subject comprising administering to the subject an adenovirus comprising the E1A polypeptide comprising one or more modifications and comprising the E4orf6/7 polypeptide comprising one or more modifications.
    Type: Application
    Filed: July 9, 2021
    Publication date: March 31, 2022
    Applicant: Salk Institute for Biological Studies
    Inventors: Clodagh O'Shea, Shigeki Miyake-Stoner
  • HIGH THROUGHPUT ASSAY FOR MEASURING ADENOVIRUS REPLICATION KINETICS
    Publication number: 20220090123
    Abstract: Recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in high-throughput assays to measure virus replication kinetics. Methods for measuring replication kinetics of a recombinant adenovirus are also described.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 24, 2022
    Applicant: Salk Institute for Biological Studies
    Inventors: Clodagh O'Shea, William Partlo, Colin Powers
  • RNA targeting methods and compositions
    Patent number: 11228547
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: January 18, 2022
    Assignee: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • CELLS, ISLETS, AND ORGANOIDS THAT EVADE IMMUNE DETECTION AND AUTOIMMUNITY, METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20210363490
    Abstract: The invention features cells, islet-like cells, pancreatic islets and organoids (e.g., human islet-like organoids or HILOs), as well as cell cultures and methods that are useful for the rapid and reliable generation of cells and organoids, such as pancreatic islets and organoids, that are sustainable in vivo and that evade immune detection, rejection and autoimmunity. The invention also features methods of treating pancreatic diseases, such as type 2 diabetes, and pancreatic cancer, using the cells, islet-like cells, pancreatic islets and organoids (e.g., HILOs) that are designed to modulate the activity of immune cells that would otherwise react against them.
    Type: Application
    Filed: October 11, 2019
    Publication date: November 25, 2021
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Eiji YOSHIHARA, Ruth YU, Michael DOWNES, Ronald EVANS, Annette ATKINS
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344626
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344629
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344631
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344627
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344628
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • RNA TARGETING METHODS AND COMPOSITIONS
    Publication number: 20210344630
    Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 4, 2021
    Applicant: Salk Institute for Biological Studies
    Inventors: Patrick D. Hsu, Silvana Konermann
  • PPAR agonists and methods of use thereof
    Patent number: 11130779
    Abstract: Provided herein are deuterated compounds and compositions useful in increasing PPAR? activity. The compounds have a formula where L5 comprises at least one deuterium. Exemplary species include The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: September 28, 2021
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael Downes
  • High throughput assay for measuring adenovirus replication kinetics
    Patent number: 11130968
    Abstract: Recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in high-throughput assays to measure virus replication kinetics. Methods for measuring replication kinetics of a recombinant adenovirus are also described.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 28, 2021
    Assignee: Salk Institute for Biological Studies
    Inventors: Clodagh O'Shea, William Partlo, Colin Powers
  • COMPOSITIONS AND METHODS FOR TREATING TYPE 1 AND TYPE 2 DIABETES AND RELATED DISORDERS
    Publication number: 20210283187
    Abstract: The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or a related disorder.
    Type: Application
    Filed: January 5, 2021
    Publication date: September 16, 2021
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: RONALD M. EVANS, EIJI YOSHIHARA, MICHAEL R. DOWNES, RUTH T. YU, ANNETTE R. ATKINS