Abstract: A system for and a method of analyzing a corneal lesion using an anterior segment image according to the present invention. The system includes: an image acquisition unit configured to acquire an anterior segment image from the eyeball of a subject, a feature extractor configured to extract feature information on a position and a cause of a lesion in the cornea from the anterior segment image by applying a convolution layer to the anterior segment image through machine learning on the basis of a database in which clinical information pre-acquired by analyzing positions and causes of lesions in the corneas of subjects is stored; and a result determination unit configured to identify a position of the cornea from the anterior segment image using the feature information and to analyze and determine the position and the cause of the lesion in the cornea from the position of the cornea.

Abstract: The present invention relates to an apparatus for predicting a region-specific cerebral cortical contraction rate on the basis of a CT image.

Abstract: The present disclosure relates to an exercise apparatus which may be easily manipulated by a physically disabled patient on a bed. An exercise apparatus according to an embodiment of the present disclosure includes an elastic band and a pair of balls connected to both ends of the elastic band, wherein the elastic band includes a hanging portion forming a closed-loop in each of both sides of the elastic band, and the pair of balls each comprise a penetration portion into which the hanging portion is inserted and fixed.

Abstract: According to an embodiment of the present disclosure, there is provided a method of predicting a brain tissue lesion distribution, the method including: a model learning operation of learning a prediction model for predicting a brain tissue lesion distribution of a subject by using brain image data of a plurality of previous patients; an input obtaining operation of obtaining input data from brain image data of the subject; and an output operation of generating output image data including information on the lesion distribution after recanalization treatment for the subject, by using the prediction model. The prediction model includes a success prediction model that is learned by using data of patients in which recanalization treatment is successful among the plurality of previous patients, and a failure prediction model that is learned by using data of patients in which recanalization treatment fails among the plurality of previous patients.

Abstract: The lead implanted in a body to apply electrical stimulation to body organs may include: an electrode wire having one end provided as an insertion portion to be inserted into a body and the other end provided as an interface portion for connection with an external device to transmit a stimulation signal: a plurality of first electrodes in the insertion portion; a plurality of second electrodes on the interface portion; and a plurality of signal lines interconnecting the first electrodes and the second electrodes, wherein the insertion portion of the electrode wire includes a plurality of support portions on which the first electrodes are respectively disposed and a plurality of stretchable portions between the support portions and expandable and contractible, and further includes an operation unit for pushing or pulling each support portion in a longitudinal direction of the electrode wire to adjust a position of the support portion.

Abstract: The present disclosure relates to a pharmaceutical composition comprising an exosome derived from a thrombin-treated stem cell as an effective ingredient for preventing or treating a skin wound, a pharmaceutical formulation containing the same, and a production method thereof. Being a cell-free agent, an exosome-based therapeutic agent of the present disclosure has a low risk of carcinogenesis and no problems of graft rejection as well as being little liable to occur microvascular obstruction. The agent, which is not a cell, but a material isolated from a cell, can be subjected to medication development into an off-the-shelf product which allows for the reduction of production cost. The agent has the advantage of exhibiting outstanding angiogenesis and skin wound treatment effects even at a low concentration of exosomes thanks to the thrombin treatment effect.

Abstract: An implantable lead having adjustable electrode locations and a system for controlling the same. The implantable lead may include a plurality of first electrodes exposed and formed at an upper part of a main body at given intervals, a plurality of second electrodes coupled to a stepped lower part of the main body and configured to deliver a stimulus signal to a core area into which the lead is inserted, and a plurality of signal lines embedded in the main body and configured to connect the first electrodes and the second electrodes in a one-to-one manner. In this case, a slot for coupling and up and down movement of the second electrodes may be formed in the lower part. As the second electrodes are individually moved along the slot by an external force acting on the signal lines, locations of the second electrodes in the lower part may be adjusted.

Abstract: Provided are a method and a device for encapsulating a cell in droplet for single-cell analysis, or a method and a device for forming droplet for single-cell analysis. According to the method and the device of one aspect, by using the effects of inertial ordering, not only a ratio at which one cell is encapsulated in one droplet is increased, but also a yield of generating droplet is improved.

Abstract: A method for collateral circulation assessment, using dynamic MRI images, includes the steps of: receiving dynamic perfusion MRI images of a subject by an analysis device; extracting arterial phase images, capillary phase images, and venous phase images from the dynamic perfusion MRI images by the analysis device; inputting the arterial phase images, capillary phase images, and venous phase images into pre-trained, deep learning models, respectively, to calculate a plurality of collateral circulation prediction probability values by the analysis device; and conducting a final collateral circulation assessment for the subject, using the plurality of collateral circulation prediction probability values by the analysis device.

Abstract: The present disclosure relates to a medium composition for enhancing proliferation of stem cells, comprising ethionamide, and a use thereof. It is possible, according to the present disclosure, to mass-produce highly-efficient next-generation stem cells through a simple and safe method of controlling a culturing environment, without using genetic modification or viral vectors, etc.

Abstract: The present invention relates to a guider for separating a tube, and more particularly, to a guider for easily separating a tube and a catheter which are coupled to each other. The guider for separating a tube according to an exemplary embodiment of the present invention may include: a cylindrical body portion which includes a through space which is opened at both ends thereof and formed to enable a tube to penetrate therethrough; and a wing portion which is connected to an outer surface of the body portion and transmits rotational force to the body portion.

Abstract: An upper limb stabilizing apparatus includes: an arm resting portion where an arm is rested; an arm fixing portion where the rested arm is fixed; a hand resting portion connected to the arm resting portion and where a hand is rested; a hand fixing portion where the rested hand is fixed; and a Velcro portion arranged at the arm fixing portion and the hand fixing portion to attach or detach the arm fixing portion and the arm resting portion, and the hand fixing portion and the hand resting portion, respectively, to or from each other.

Abstract: The present invention relates to a conversion device for converting a treatment beam for treating a lesion of a subject, comprising: a collimator unit to which the treatment beam is incident and which has a plurality of slits; and a scattering unit that scatters the treatment beam that has passed through the collimator unit.

Abstract: Disclosed is a fine dust collecting device using a human body based electrostatic energy harvesting element. The fine dust collecting filter device includes an electrostatic energy harvesting element for collecting and generating current; a charging filter connected to the electrostatic energy harvesting element such that the charging filter is electrically charged to have a first polarity and thus electrically charges fine dust particles; a collecting filter connected to the electrostatic energy harvesting element such that the collecting filter is electrically charged to have a second polarity opposite to the first polarity; and a rectifier disposed between and connected to the electrostatic energy harvesting element, and the charging filter and the collecting filter.

Abstract: A deep learning model-based tumor-stroma ratio prediction method comprises the steps in which an analysis device: receives an input of a first staining image of target tissue; generates a second staining image by inputting the first staining image into a trained deep learning model; generates a first binary image of the first staining image; generates a second binary image of the second staining image; and calculates the tumor-stroma ratio of the target tissue on the basis of the first binary image and the second binary image.

Abstract: The present invention is directed to a method of measuring cell migration by measuring the invasion ratio of cells incubated on a pillar array inserted into a well structure, the method including steps of: preparing a pillar array having a plurality of micropillars and a well structure having a plurality of microwells into which the plurality of micropillars is insertable, respectively; forming cell spheroids by incubating cells in an extracellular matrix attached to the end contact surfaces of the micropillars; allowing the cells contained in the cell spheroids to invade the end contact surfaces; staining and scanning the cell spheroids, the cells contained in the cell spheroids, and the cells that invaded the end contact surfaces; and calculating the invasion ratio of cells by the following equation through a fluorescence image of the scanned cells: Invasion ? Ratio = Invasion ? cell ? area Total ? cell ? area = A Total - A spheroid A Total [ Equation ] wherei

Abstract: Provided is a dielectrophoresis-based dynamic Surface-Enhanced Raman Spectroscopy (SERS) nanoelement for the classification and analysis of metabolites. A method for analyzing metabolites using a dielectrophoresis-based dynamic SERS nanoelement according to an embodiment of the present invention may comprise the steps of: preparing a dynamic SERS nanoelement in which a surface region is formed as an array; applying voltage to the dynamic SERS nanoelement; and classifying the metabolites of an analysis subject according to region by controlling the polarity of the dynamic SERS nanoelement according to the voltage applied.

Abstract: The present invention relates to a screening method for a therapeutic agent for pulmonary damage induced by the administration of high-concentration oxygen, and more specifically, to a screening method for a candidate material for a therapeutic agent for bronchopulmonary dysplasia (BPD) induced by the administration of high-concentration oxygen. The present inventors have discovered that FPR1 is over-expressed in lung tissues exposed to high-concentration oxygen, and as a result of focusing on the correlation between the expression of FPR1 and the development of BPD, have confirmed that BPD can be suppressed by inhibiting the expression or activity of FPR1. In view of this fact, a prophylactic or therapeutic material for BPD may be discovered in a rapid and accurate manner by checking whether the expression or activity level of FPR1 is inhibited, and thus, the screening method of the present invention may be beneficially used to effectively select and develop therapeutic agents for BPD.

Abstract: Disclosed herein a method of constructing a blood vessel map, the method including: receiving, by a blood vessel map construction apparatus, a TOF image of the object; extracting, by the blood vessel map construction apparatus, a blood vessel stem, a center line of a blood vessel, and features of the center line included in the TOF image, and detecting branch points of the blood vessel based on the extracted blood vessel stem, center line of the blood vessel, and features of the center line; searching, by the blood vessel map construction apparatus, a reference blood vessel image corresponding to the TOF image in consideration of location information or curvature information of the branch points; calculating a similarity between the TOF image and the reference blood vessel image; and registering the TOF image in the blood vessel map based on the similarity.

Abstract: The present disclosure relates to a method of selecting stem cells having the ability to produce extracellular vesicles with high efficiency, the method including the step of measuring the activity of protease-activated receptor (PAR)-mediated signaling pathways, stem cells selected by the method, and a method of screening an inducer for the production of extracellular vesicles. According to the present disclosure, upon treatment of stem cells with thrombin, the production of extracellular vesicles in the stem cells and the levels of proteins in the extracellular vesicles are significantly increased via PAR-mediated signaling pathways, and thus stem cells having the ability to produce extracellular vesicles with high efficiency can be efficiently selected by treating stem cells with thrombin and measuring an activation level of a PAR-mediated signaling pathway, and stem cells selected by this method can be effectively used in related research and clinical fields.