Patents Assigned to Science-Union et Cie
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Patent number: 4086355Abstract: The invention relates to novel spirodecane derivatives and more specifically to novel azaspirodecane diones.The invention also provides process for producing said azaspirodecane diones which consists mainly in cyclizing a disubstituted glutaronitrile or a glutaric acid in the presence of an amino compound.The compounds of the present invention have interesting pharmacological properties and they find therapeutical uses.Type: GrantFiled: January 19, 1976Date of Patent: April 25, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Jean-Claude Poignant
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Patent number: 4080452Abstract: This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof.The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.Type: GrantFiled: February 9, 1976Date of Patent: March 21, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Xavier Pascaud
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Patent number: 4071629Abstract: This invention relates to pharmaceutical compositions having psychoanaleptic activity containing a thiamine disulphide derivative as active ingredient.The novel pharmaceutical composition has therapeutical utility, namely, in the treatment of psychic and/or behavioral disturbances due to psychasthenia.Type: GrantFiled: August 27, 1976Date of Patent: January 31, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Jacques Servier
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Patent number: 4070485Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.Type: GrantFiled: September 16, 1976Date of Patent: January 24, 1978Assignee: Science Union et CieInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
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Patent number: 4066662Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: December 30, 1976Date of Patent: January 3, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4064245Abstract: Phenoxy compounds of the formula: ##STR1## wherein R and R', which are the same or different, are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, lower alkoxy-carbonyl or dimethylsulfamoyl.These compounds are used as medicines especially in the treatment of glucid -- and lipid -- metabolism disorders.Type: GrantFiled: July 14, 1976Date of Patent: December 20, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4059621Abstract: This invention relates to propanol derivatives and to a process for their preparation.Type: GrantFiled: July 16, 1973Date of Patent: November 22, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4056623Abstract: Pharmaceutical compositions containing a compound selected from N-phenyl sulphonyl-N'-(3-azabicycloalkyl) ureas or physiologically acceptable salts thereof and an appropriate pharmaceutical carrier for reducing the risk of arteriosclerosis.Type: GrantFiled: June 3, 1976Date of Patent: November 1, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventor: Jacques Duhault
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Patent number: 4048321Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: September 13, 1977Assignee: Science Union et CieInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4048313Abstract: This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.Type: GrantFiled: January 9, 1975Date of Patent: September 13, 1977Assignee: Science Union et CieInventors: Michel Vincent, Georges Remond, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4042598Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: August 16, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4032648Abstract: (3-amino-2-hydroxy propyloxy) thiochromans of the formula ##STR1## wherein A is hydrogen or halogen, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 is lower alkyl or cyclo lower alkyl.These compounds possess cardiovascular properties and may be used as blockers of cardiac .beta. adrenergic receptors.Type: GrantFiled: April 22, 1976Date of Patent: June 28, 1977Assignee: Science Union et CieInventors: Charles Malen, Michel Laubie
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Patent number: 4032658Abstract: Alkanolamine derivatives and their optical isomers of the formula: ##STR1## wherein: N IS 2 OR 3, ANDR.sub.1 and R.sub.2 are lower alkyl or taken together with the nitrogen to which they are bonded, they form pyrrolidinyl, piperidino, dimethyl piperidino, morpholino, 1-thiomorpholino, azabicyclo [3, 3, 0] octyl or azabicyclo [3, 2, 2] nonyl.These compounds are used as medicines especially in the treatment of obesity, atheroma or metabolic diseases requiring weight reduction and regulation.Type: GrantFiled: April 23, 1975Date of Patent: June 28, 1977Assignee: Science-Union et CieInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4027028Abstract: This invention relates to amino piperidines bearing on the endocyclic nitrogen atom an aryloxy alkyl side chain and the acid addition salts thereof. This invention also relates to processes for making the same.The compounds of this invention have therapeutical utility namely in the cardiovascular field. They may be used in the form of pharmaceutical compositions.DESCRIPTION OF THE PRIOR ARTThe prior art may be illustrated with the following referencesFrench drug Patents Nos. 2429 M; 2430 M; 2431 M;Belgian Patent No. 615,350.SUMMARY OF THE INVENTIONThis invention relates to new 4-amino piperidines and more particularly to N-aralkoxy 4-phenylamino piperidines. The aryl and phenyl nuclei may be unsubstituted or substituted by one or several substituents.This invention also provides processes for producing such compounds. Namely they may be produced by condensing an aryloxy alkyl halide with a 4-phenylamino piperidine.Type: GrantFiled: November 10, 1975Date of Patent: May 31, 1977Assignee: Science Union et CieInventors: Michel Vincent, Georges Remond, Michel Laubie
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Patent number: 4010267Abstract: Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl,R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, orR.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- andHet is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl.These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.Type: GrantFiled: March 26, 1975Date of Patent: March 1, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicalInventors: Gilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignant
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Patent number: 4001420Abstract: m-(thiazol-4-yl) benzoic acids substituted in 2- and optionally 5-position of the thiazol ring by lower alkyl, phenylalkyl, phenyl, halo-phenyl, lower alkylphenyl or lower alkoxyphenyl, and on the phenyl ring of the benzoic acid moiety by halogen, hydroxyl, lower alkyl or lower alkoxy. These compounds possess fibrinolytic, platelet stickiness decreasing and antiulcer properties and have an impact on the immunological processes.Type: GrantFiled: April 25, 1974Date of Patent: January 4, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicalInventors: Charles Malen, Pierre Desnoyers
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Patent number: 3989834Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.Type: GrantFiled: March 13, 1975Date of Patent: November 2, 1976Assignee: Science Union et Cie, Societe Francaise de Recherche MedicalInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
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Patent number: 3988464Abstract: The present invention relates to cyclopropylmethyl amines substituted by a heterocyclic radical.More particularly the heterocyclic radical is a nitrogen containing ring with 5, 6 or 7 links interrupted by another hetero atom selected from the group consisting of oxygen, sulphur and imino--NH--The invention also relates to the acid addition salts thereof with physiologically compatible mineral or organic acids.The invention extends to the processes for making them and the intermediates produced hereto.The invention also includes the pharmaceutical compositions incorporating as active ingredient at least one compound of the invention with an inert carrier.The compounds have therapeutic utility namely on the cardio-vascular diseases and on the neuro-psychological disturbances.Type: GrantFiled: December 26, 1973Date of Patent: October 26, 1976Assignee: Science Union et Cie, Societe Francaise de Recherche MedicalInventors: Charles Malen, Monique Desnos, Michel Laubie, Jean-Claude Poignant
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Patent number: 3983249Abstract: This application is directed to certain novel sulfonyl urea compounds, to their use as antianginal agents, and to the use of certain prior art sulfonyl ureas as antianginal agents. The sulfonyl ureas are characterized in that they are N-arylsulfonyl-N'-methyl-N'(aza-3-bicycloalkyl) ureas and N-arylsulfonyl-N'-(aza-3-bicycloalkyl) ureas.Type: GrantFiled: December 26, 1974Date of Patent: September 28, 1976Assignee: Science Union et Cie Societe Francaise de Recherche MedicalInventors: Stewart J. Ehrreich, Lester Zitowitz
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Patent number: 3978044Abstract: This invention relates to indazole derivatives, to processes for their preparation and to pharmaceutical compositions containing them.More specifically this invention relates to 4, 5, 6, 7-tetrahydroindazoles bearing at the 3-position an amino substituent.This invention also relates to processes for producing the same which include the steps of condensing a substituted cyclohexanone with a secondary amine, reacting the thus formed enamine either with an isocyanate or thiocyanate or with phosgene imonium salt and cyclizing the intermediate compound with a hydrazino derivative.The compounds of the invention have therapeutic utility, namely as a means for controlling fertility in mammals.Type: GrantFiled: April 22, 1975Date of Patent: August 31, 1976Assignee: Science Union et CieInventors: Michel Vincent, Georges Remond