Abstract: Disubstituted azabicycloalkanes of the formula ##SPC1##Wherein:n is 0, 1 or 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
Type:
Grant
Filed:
November 20, 1974
Date of Patent:
August 3, 1976
Assignee:
Science Union et Cie
Inventors:
Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
Abstract: Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.
Type:
Grant
Filed:
September 22, 1975
Date of Patent:
July 20, 1976
Assignee:
Science Union et Cie, Societe Francaise de Recherche Medical
Inventors:
Gilbert Regnier, Roger Canevari, Xavier Pascaud
Abstract: Heterocyclic amides of the formula: ##SPC1##Wherein:X is N or CH;n is O or 1 andR is ##EQU1## or ##SPC2##Wherein:R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.
Type:
Grant
Filed:
May 1, 1974
Date of Patent:
July 20, 1976
Assignee:
Science Union et Cie, Societe Francaise de Racherche Medical
Inventors:
Gilbert Regnier, Roger Canevari, Xavier Pascaud
Abstract: Pharmaceutical compositions containing tetrahydroalstonine or a therapeutically acceptable salt thereof are disclosed. These compositions are useful for treating circulation disorders and more particularly brain circulation disorders.
Type:
Grant
Filed:
October 17, 1974
Date of Patent:
July 13, 1976
Assignee:
Science Union et Cie, Societe Francaise de Recherche Medical
Abstract: (3-amino-2-hydroxy propyloxy) thiochromans of the formula ##SPC1##Wherein A is hydrogen or halogen, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 is lower alkyl or cyclo lower alkyl.These compounds possess cardiovascular properties and may be used as blockers of cardiac .beta. adrenergic receptors.
Abstract: N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl.These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.
Type:
Grant
Filed:
August 5, 1974
Date of Patent:
May 11, 1976
Assignee:
Science Union et Cie, Societe Francaise de Recherche Medical
Inventors:
Laszlo Beregi, Charles Malen, Pierre Hugon, Jacques Duhault
Abstract: Piperazine derivatives of the formula: ##SPC1##Wherein n is 0 or 1, X is oxygen or sulfur, R and R', which are the same or different, are hydrogen or lower alkyl and: ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicine especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and pain.
Type:
Grant
Filed:
October 7, 1974
Date of Patent:
May 4, 1976
Assignee:
Science-Union et Cie
Inventors:
Gilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignant
Abstract: Disubstituted piperazines of the formula: ##SPC1##Wherein:n is 1 or 2;X is oxygen or sulfur;R is hydrogen or lower alkyl;Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.
Type:
Grant
Filed:
March 25, 1974
Date of Patent:
March 16, 1976
Assignee:
Science-Union et Cie
Inventors:
Gilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignantw