Patents Assigned to SERVICIO ANDALUZ DE SALUD
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Patent number: 11565019Abstract: The present invention provides for nanostructured fibrin and agarose hydrogels, preferably type VII agarose hydrogels, (NFAH) or non-nanostructured or pre-nanostructured fibrin and agarose hydrogels, preferably type VII agarose hydrogels, (FAH), as hemostatic agents designed for use as an adjunct or primary treatment in moderate intraoperative hemorrhage and in trauma. These hydrogels can be applied topically to the wound either on the skin in a laparotomy or as non-invasive manner in surgical procedures. Its nanostructure technology generates an adhesive stable fibrin clot required for hemostasis. The attachment properties of the hydrogel, as well as the rapid formation of a fibrin clot, ensures that a strong stable fibrin clot is formed shortly after application.Type: GrantFiled: April 8, 2019Date of Patent: January 31, 2023Assignees: FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD, SERVICIO ANDALUZ DE SALUDInventors: Rafael Campos Cuerva, Beatriz Fernandez Muñoz, Miguel Angel Gómez Bravo, Carmen Cepeda Franco, Jordi Muntane Relat
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Patent number: 11344531Abstract: The invention relates to an aqueous melatonin composition exhibiting surprising long-term stability and allowing high concentrations of said water-insoluble active ingredient. The properties of said composition render it useful as an injectable, for example, for the intravenous administration thereof.Type: GrantFiled: March 27, 2015Date of Patent: May 31, 2022Assignees: Servicio Andaluz de Salud, Universidad de GranadaInventors: Darío Acuña Castroviejo, Germaine Escames Rosa, Pablo Bueno Laraño, Alfonso Mansilla Roselló, José Antonio Ferrón Orihuela, José Jorge Hernández Magdalena, Miguel Ángel Calleja Hernández, Desirée González Callejas, Ana Comino Pardo, Carmen Olmedo Martín, Carmen Venegas Maldonado
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Patent number: 11344260Abstract: The invention describes a method for predicting or prognosticating the risk of death or vasospasm in a patient with a subarachnoid hemorrhage, which comprises the following steps: performing a clinical assessment of the patient according to the Hunt and Hess scale and the World Federation of Neurosurgeons (WFNS) scale; obtaining a computerised axial tomography image of the patient's skull; normalising the image obtained according to a standard skull template; obtaining a region corresponding to intracranial blood by segmenting the normalised image; calculating at least the following parameters of the region of cranial blood obtained: total volume, fractal dimension and surface-volume ratio; and determining the probability of death or vasospasm in the patient according to at least the parameters calculated.Type: GrantFiled: July 30, 2018Date of Patent: May 31, 2022Assignees: SERVICIO ANDALUZ DE SALUD, UNIVERSIDAD DE SEVILLAInventors: Juan José Egea Guerrero, Marcin Wojciech Balcerzyk
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VACCINE AGAINST ACINETOBACTER BAUMANNII BASED ON CELLULAR COMPONENTS DEFICIENT IN LIPOPOLYSACCHARIDE
Publication number: 20220152184Abstract: The invention refers to a composition comprising inactivated cells deficient in LPS from the genus Acinetobacter and/or outer membrane vesicles form the same and their use for the manufacture of a medicament, preferably a vaccine, for the prevention of diseases produced by organisms of the genus Acinetobacter.Type: ApplicationFiled: September 29, 2021Publication date: May 19, 2022Applicants: VAXDYN S.L., FUNDACIÓN PÚBLICA ANDALUZA PARA LA GESTIÓN DE LA INVESTIGACIÓN EN SALUD DE SEVILLA, SERVICIO ANDALUZ DE SALUDInventors: Michael James McConnell, Meritxell García Quintanilla, Marina Pulido Toledano, María Pilar Pérez Romero, Jerónimo Pachón Díaz, Juan José Infante Viñolo -
Publication number: 20220050098Abstract: The present invention provides a method for identifying epithelial cells circulating in peripheral blood, which allows individuals who suffer from a disease that presents with epithelial cell destruction to be discriminated from those who do not. The invention also relates to a kit or device for carrying out the methods of the invention.Type: ApplicationFiled: October 28, 2021Publication date: February 17, 2022Applicants: UNIVERSIDAD DE GRANADA, SERVICIO ANDALUZ DE SALUDInventors: Pedro José ROMERO PALACIOS, Juan José DÍAZ MOCHÓN, José Antonio LORENTE ACOSTA, Diego DE MIGUEL PÉREZ, María José SERRANO FERNÁNDEZ, Bernardino ALCÁZAR NAVARRETE
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Patent number: 11161149Abstract: The invention relates to a wave-emitting device comprising an electromechanical actuator stimulated by a signal generator that allows it to generate torsional waves with a higher amplitude, and to an ultrasonic transducer comprising said device. The use of said devices allows the reconstruction of the structural characteristics of the materials subject to the waves generated by the emitter device.Type: GrantFiled: July 18, 2016Date of Patent: November 2, 2021Assignees: Universidad De Grenada, Servicio Andaluz De SaludInventors: Guillermo Rus Calborg, Alicia Valera Martínez, Elena Sánchez Muñoz, Francisca Molina García
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Patent number: 11160856Abstract: The invention refers to a composition comprising inactivated cells deficient in LPS from the genus Acinetobacter and/or outer membrane vesicles form the same and their use for the manufacture of a medicament, preferably a vaccine, for the prevention of diseases produced by organisms of the genus Acinetobacter.Type: GrantFiled: January 24, 2018Date of Patent: November 2, 2021Assignees: Vaxdyn S.L., Fundación Pública Andaluza para la Gestión de la Investigación en Salud De Sevilla, Servicio Andaluz de SaludInventors: Michael James McConnell, Meritxell García Quintanilla, Marina Pulido Toledano, María Pilar Pérez Romero, Jerónimo Pachón Díaz, Juan José Infante Viñolo
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Patent number: 11034031Abstract: A tool coupling includes a first tool part and a second tool part, the second tool part being movable in relation to the first tool part. The tool coupling further includes a first base part for detachably retaining the first tool part and a second base part movable in relation to the first base part for detachably retaining the second tool part. The first base part has a pusher movable in relation to the first base part for detaching the first tool part and the second base part has a cap movable in relation to the second base part for detaching the second tool part.Type: GrantFiled: June 23, 2017Date of Patent: June 15, 2021Assignees: FUNDACIÓN TECNALIA RESEARCH & INNOVATION, UNIVERISAD DE CÓRDOBA, SERVICIO ANDALUZ DE SALUD, UNIVERISAD DE MÁLAGAInventors: Julius Klein Hubert, Asier Fernández Iribar, Rafael Medina Carnicer, Rafael Muñoz Salinas, Enrique Bauzano Núñez, Mᵃ Carmen López Casado, Víctor Fernando Muñoz Martínez, María José Requena Tapia, José Eduardo Arjona Berral, Rosa María Paredes Esteban, Ángel Salvatierra Velázquez, Ignacio Muñoz Carvajal, Javier Briceño Delgado
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Patent number: 10960011Abstract: The invention relates to compositions used to relieve, improve, prevent and/or treat stretch marks and/or skin ulcers preferably of ischemic origin. The invention also relates to the composition, dosage form and uses thereof.Type: GrantFiled: June 23, 2017Date of Patent: March 30, 2021Assignee: SERVICIO ANDALUZ DE SALUDInventors: José Bernabeu Wittel, Raquel Cabrera Fuentes
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Patent number: 10869886Abstract: The present invention refers to a cell suspension of autologous or allogeneic, preferably autologous, adult bone marrow-derived white blood cells, preferably derived from the crest of the ilium (or iliac crest), enriched for mononuclear cells, meaning more than 25% of the white blood cells (WBCs) present in the cell suspension are mononuclear cells, and comprising: A. Mononuclear cells (MNC) selected from the list comprising or consisting of: i. A population of Lymphocytes; ii. A population of Monocytes; and iii. A population of Hematopoietic stem cells expressing CD34; and wherein the cell suspension further comprises: B. Granulocytes; for use in the treatment or amelioration of lower extremity peripheral artery disease.Type: GrantFiled: August 28, 2017Date of Patent: December 22, 2020Assignees: REXGENERO BIOSCIENCES S.L., SERVICIO ANDALUZ DE SALUD, FUNDACIÜBLICA ANDALUZA PROGRESO Y SALUDInventors: Jonathan Robert Barclay Dupere, Liesbeth de Jong, Edwin J. Wagena, Inmaculada Concepción Herrera Arroyo
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Patent number: 10799114Abstract: The invention relates to a novel open retinoscope comprising: a body (3) comprising a light source (31) oriented in the longitudinal direction and a first coupling means (32) for coupling to a Volk lens (51) holder in a longitudinally sliding manner; a Volk lens (51) holder (5), coupled in a longitudinally sliding manner to the body (3), where the holder (5) comprises a second longitudinal sliding coupling means (52) which is complementary to the first longitudinal sliding coupling means (32) of the body (3); and a smartphone adaptor (2) which can be connected to the body (3) in a transversely sliding manner.Type: GrantFiled: December 29, 2015Date of Patent: October 13, 2020Assignees: SERVICIO ANDALUZ DE SALUD [ES/ES], Hospital San Juan de Dios del Aljarafe [ES/ES]Inventors: Florencio González Márquez, Francisco Javier Henández Martinez, Luis Gabriel Luque Romero, Luis Castillón Torres, Jose Luis García Garmendia, Gorka Gómez Ciriza, Cristina Suárez Mejías, Tomás Gómez Cía
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Patent number: 10702218Abstract: The invention relates to a method for obtaining useful data about the angiogenesis in a patient's lower limbs, and particularly in the lower limbs of patients with diabetes subjected to treatment.Type: GrantFiled: December 14, 2015Date of Patent: July 7, 2020Assignees: Servicio Andaluz de Salud, Universidad de CórdobaInventors: José García-revillo García, Miguel Canis López, Noelia Romero Mata
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Patent number: 10463670Abstract: Use of the non-peptide NK1 receptor antagonist, preferably Aprepitant, for the treatment of cancer in predetermined doses. The present invention also describes pharmaceutical compositions comprising said agents, alone or in combination with at least one other active principle, for the treatment of cancer.Type: GrantFiled: June 27, 2017Date of Patent: November 5, 2019Assignee: SERVICIO ANDALUZ DE SALUDInventor: Manuel Vicente Salinas Martín
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Publication number: 20190307694Abstract: The present invention relates to a composition comprising a neurokinin-1 receptor antagonist and at least one excipient selected from an oil, a fatty acid or a polyol, as well as to an administration form for administering a formulation, wherein said administration form is selected from: inhalant, nebulization, vapor, smoke or aerosol and comprises said composition. In addition, the invention relates to said composition for use as medicament, said administration form for use as medicament, preferably said composition for use as medicament in the treatment of at least one disease of the respiratory tract, or said administration form for use as medicament in the treatment of at least one disease of the respiratory tract. Moreover, the invention also provides methods for producing said composition and said administration form, as well as a kit of parts comprising said composition and an administration device.Type: ApplicationFiled: April 19, 2019Publication date: October 10, 2019Applicants: PLUS VITECH, S.L., SERVICIO ANDALUZ DE SALUDInventors: Antonio Lara Ruiz, Manuel Vicente Salinas Martin
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Publication number: 20190217483Abstract: A tool coupling includes a first tool part and a second tool part, the second tool part being movable in relation to the first tool part. The tool coupling further includes a first base part for detachably retaining the first tool part and a second base part movable in relation to the first base part for detachably retaining the second tool part. The first base part has a pusher movable in relation to the first base part for detaching the first tool part and the second base part has a cap movable in relation to the second base part for detaching the second tool part.Type: ApplicationFiled: June 23, 2017Publication date: July 18, 2019Applicants: Fundación Tecnalia Research & Innovation, Universsidad de Córdoba, Servicio Andaluz de Salud, Universidad de MálagaInventors: Julius KLEIN HUBERT, Asier FERNÁNDEZ IRIBAR, Rafael MEDINA CARNICER, Rafael MUÑOZ SALINAS, Enrique BAUZANO NÚÑEZ, Mª Carmen LÓPEZ CASADO, Víctor Fernando MUÑOZ MARTÍNEZ, María José REQUENA TAPIA, José Eduardo ARJONA BERRAL, Rosa María PAREDES ESTEBAN, Ángel SALVATIERRA VELÁZQUEZ, Ignacio MUÑOZ CARVAJAL, Javier BRICEÑO DELGADO
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Publication number: 20190194749Abstract: The invention relates to a method for the diagnosis of liver fibrosis, comprising detecting the level of expression of the gene GATA-4, or the quantity of the protein GATA-4, in the isolated biological sample of liver tissue. The invention also relates to a diagnosis kit.Type: ApplicationFiled: April 30, 2014Publication date: June 27, 2019Applicants: UNIVERSIDAD PABLO DE OLAVIDE, UNIVERSIDAD DE SEVILLA, SERVICIO ANDALUZ DE SALUD, FUNDACIÓN PÚBLICA ANDALUZA PARA LA GESTIÓN DE LA INVESTIGACIÓN EN SALUD DE SEVILLAInventors: Ana Isabel Rojas Gonzalez, David Cano Gonzalez, Irene Delgado Sainz, Bernat Soria Escoms, Francisco Martin Bermudez, Manuel Romero Gomez
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VACCINE AGAINST ACINETOBACTER BAUMANNII BASED ON CELLULAR COMPONENTS DEFICIENT IN LIPOPOLYSACCHARIDE
Publication number: 20180256700Abstract: The invention refers to a composition comprising inactivated cells deficient in LPS from the genus Acinetobacter and/or outer membrane vesicles form the same and their use for the manufacture of a medicament, preferably a vaccine, for the prevention of diseases produced by organisms of the genus Acinetobacter.Type: ApplicationFiled: January 24, 2018Publication date: September 13, 2018Applicants: VAXDYN S.L, FUNDACIÓN PÚBLICA ANDALUZA PARA LA GESTIÓN DE LA INVESTIGACIÓN EN SALUD DE SEVILLA, SERVICIO ANDALUZ DE SALUDInventors: Michael James McConnell, Meritxell García Quintanilla, Marina Pulido Toledano, María Pilar Pérez Romero, Jerónimo Pachón Díaz, Juan José Infante Viñolo -
Patent number: 10059998Abstract: The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of particular miRNAs. Specifically, the invention relates to a method for determining the risk of recurrence of breast cancer which comprises measuring the expression levels of at least one miRNA selected from the group consisting of miR-149-5p (SEQ ID NO: 1), miR-10a-5p, (SEQ ID NO: 2), miR-20b-5p, (SEQ ID NO: 3), miR-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumor, wherein a change in the expression level of at least one miRNA in the tumor with respect to the expression level in a control sample is indicative of a high risk of recurrence of the tumor. The invention also relates to tools and kits for carrying out the method of the invention.Type: GrantFiled: March 13, 2015Date of Patent: August 28, 2018Assignees: Servicio Andaluz de Salud, Fundacion Publica Andaluza para la Investigacion de Malaga en Biomedicina y Salud (FIMABIS), Universidad de MalagaInventors: José Lozano Castro, Emilio Alba Conejo, Luis Gustavo Pérez Rivas, José Jerez Aragonés, Nuria Ribelles Entrena
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Patent number: 10045994Abstract: The present invention relates to the use of compounds of a cannabinoid nature for inhibiting viability with increasing doses of myeloma cell lines. Furthermore, said compounds have been shown not to affect CD34+ cells (normal hematopoietic progenitors) in terms of viability and proliferation. For this reason, the invention paves the way for the use of compounds of a cannabinoid nature as a promising therapy against multiple myeloma and related diseases.Type: GrantFiled: June 13, 2014Date of Patent: August 14, 2018Assignee: SERVICIO ANDALUZ DE SALUDInventors: José Antonio Pérez Simón, María Victoria Barbado González
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Publication number: 20180049637Abstract: The invention relates to a novel open retinoscope comprising: a body (3) comprising a light source (31) oriented in the longitudinal direction and a first coupling means (32) for coupling to a Volk lens (51) holder in a longitudinally sliding manner; a Volk lens (51) holder (5), coupled in a longitudinally sliding manner to the body (3), where the holder (5) comprises a second longitudinal sliding coupling means (52) which is complementary to the first longitudinal sliding coupling means (32) of the body (3); and a smartphone adaptor (2) which can be connected to the body (3) in a transversely sliding manner.Type: ApplicationFiled: December 29, 2015Publication date: February 22, 2018Applicants: SERVICIO ANDALUZ DE SALUD, Hospital San Juan de Dios del AljarafeInventors: Florencio González Márquez, Francisco Javier Henández Martínez, Luis Gabriel Luque Romero, Luis Castillón Torres, Jose Luís García Garmendia, Gorka Gómez Ciriza, Cristina Suárez Mejías, Tomás Gómez Cía