Patents Assigned to SHANGHAI JUNSHI BIOSCIENCES INC.
  • Patent number: 11267890
    Abstract: An antibody or a functional fragment thereof that specifically bind to PD-L1 with high affinity, a nucleic acid molecule that encodes said antibody or the functional fragment thereof, an expression vector and a host cell for use in expressing said antibody or the functional fragment thereof, and a method for producing said antibody or the functional fragment thereof. An immunoconjugate and a pharmaceutical composition containing said antibody or the functional fragment thereof, and a method for using said antibody or the functional fragment thereof to enhance the function of a T cell so as to up-regulate a cell-mediated immune response, for use in treating diseases caused by T cell dysfunction.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: March 8, 2022
    Assignees: SHANGHAI JUNSHI BIOSCIENCES INC., SUZHOU JUNMENG BIOSCIENCES CO., LTD.
    Inventors: Hai Wu, Sheng Yao, Yuehua Zhou, Jian Yao, Dan Meng, Hui Feng
  • Patent number: 10066013
    Abstract: This invention provides antibodies or functional fragments thereof that bind to PD-1 with high affinity. The invention provides nucleic acid molecules encoding the antibodies or the fragments thereof according to the present invention, expression vectors and host cells for expressing the antibodies or the functional fragments thereof according to the present invention, as well as methods for producing the antibodies or the functional fragments thereof according to the present invention. The present invention also provides immunoconjugates and pharmaceutical compositions comprising the antibodies or the functional fragments thereof according to the present invention. The present invention additionally provides methods for treating a plurality of diseases (comprising cancers, infectious diseases and inflammatory diseases) by using the antibodies or the functional fragments thereof disclosed herein.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: September 4, 2018
    Assignees: SHANGHAI JUNSHI BIOSCIENCES INC., JUNMENG BIOSCIENCES CO., LTD.
    Inventors: Bo Chen, Hai Wu, Hui Feng