Patents Assigned to SHIBUYA CORPORATION
  • Patent number: 11008204
    Abstract: A filling valve for filling liquid into a bottle is provided that comprises a nozzle having an outlet on its bottom end and a seat on its interior surface, a stem arranged inside the nozzle and having a plug provided on its outer periphery, a helical vane provided on the outer periphery of the stem for inducing a spiral flow, and a bevel with expanding diameter in the downward direction is provided at the bottom end of the stem. The filling valve is closed when the stem descends and the plug makes contact with the seat. The filling valve is opened when the stem ascends and the plug separates from the seat. The bevel is extended below the outlet when the plug is opened. The liquid revolved via the helical vane and ejected from the outlet is spread by the bevel toward a bottle finish or neck.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: May 18, 2021
    Assignee: SHIBUYA CORPORATION
    Inventors: Yukinobu Nishino, Shinya Kamori, Shunya Ota, Yuichi Yonemura, Taro Kitayama, Katsunori Tanikawa
  • Patent number: 10980904
    Abstract: In an aeration method for an isolator system, an incubator is connected to an isolator through a chamber. After closing a door at each sidewall of the chamber, a decontaminating gas is supplied to the chamber through gas supply passages to decontaminate the inside thereof. Next, air is supplied into the chamber through the gas supply passages and an initial aeration is carried out by discharging the decontamination gas through a gas discharge passage. Then, after a door between the isolator and the chamber is opened, and blowers are stopped, gas at a positive pressure in the isolator is introduced into the chamber. The decontaminating gas in the chamber is rapidly discharged to an outside through the gas supply passages and the gas discharge passage, and aeration in the chamber is completed. The time required for aeration of the chamber can be drastically reduced as compared with conventional aeration processes.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: April 20, 2021
    Assignee: SHIBUYA CORPORATION
    Inventors: Soma Watanabe, Yusuke Hirosawa, Katsuki Hashimoto
  • Patent number: 10870506
    Abstract: A filling system includes a conveyance chamber that conveys vessels, a filling chamber provided with a filling head that fills content into the vessels, a pressure control means that controls the pressure conditions of each chamber, an intermediate chamber that is provided between the conveyance chamber and the filling chamber, and a shutter that can separate the conveyance chamber and the intermediate chamber. When the filling chamber is separated by the shutter, the pressure control means controls the pressure of the intermediate chamber to become lower than the pressure of the conveyance chamber and the filling chamber.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: December 22, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Yukinobu Nishino, Katsunori Tanikawa, Koji Kaya, Kengo Ikeda, Shigeki Koishi, Masaaki Eda
  • Patent number: 10800611
    Abstract: A container conveyor system includes a first endless conveyor and a second endless conveyor. The first endless conveyor is provided with a plurality of neck grippers that holds the neck of a capped container and conveys the container held by the neck gripper by moving the neck gripper. The second endless conveyor is provided with a plurality of vertical grippers that comprises an upper grip member, which is liftable and abuts against the top of the cap of the container, and a support plate that supports the base of the container. The second endless conveyor conveys the container held by the upper grip member and the support plate by moving the vertical gripper. The container conveyor system conveys the container by transferring the container between the neck gripper and the vertical gripper.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 13, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Yukinobu Nishino, Koji Kaya, Kotaro Mitsutani, Mitsuo Hashimoto, Noboru Nishimura
  • Patent number: 10783470
    Abstract: A schedule management system 1 having isolators 3 (production facilities) and a main control device 4 for managing a production schedules of all the isolators 3. The production process of each isolator constituting the production schedule has a plurality of sub-processes, the production status being determined in the sub-process. The main control device 4 adds a new separating operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators. The main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: September 22, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Shiaru Muranaka, Kenji Yoneda, Hiroshi Utsumi
  • Patent number: 10746725
    Abstract: Endotoxin is detected by electrochemical measurement. A detection device 15 of endotoxin detects endotoxin contained in a fluid to be tested (for example, a dialysate) specifically in the following manner. First, the fluid to be tested is brought into contact with an adsorbent 17 that adsorbs endotoxin to cause the adsorbent 17 to adsorb the endotoxin. Then, a basic solution is brought into contact with the adsorbent 17 to desorb the endotoxin. Electrochemical measurement of the basic solution containing the desorbed endotoxin is performed. The endotoxin can be detected by the electrochemical measurement with high sensitivity at low cost.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 18, 2020
    Assignees: SHINSHU UNIVERSITY, KAIJO CORPORATION, SHIBUYA CORPORATION
    Inventors: Jiye Jin, Nobuyuki Kurashina, Junichiro Soejima, Toshiharu Sawada
  • Patent number: 10744159
    Abstract: A method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity has an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 18, 2020
    Assignees: YAMAGUCHI UNIVERSITY, SHIBUYA CORPORATION
    Inventors: Isao Sakaida, Shuji Terai, Taro Takami, Koichi Fujisawa, Naoki Yamamoto, Kenji Yoneda
  • Patent number: 10744659
    Abstract: A main isolator 2 (main aseptic device) includes a main connection part 6 having an opening O through which a work space W is externally opened, and an internal opening and closing member 22 configured to open and close an internal opening 21a of the main connection part 6 on the work space W side. A manual incubator 3 (first auxiliary aseptic device) includes a first auxiliary connection part 7 connectable with the main connection part 6 of the main isolator 2, and an automatic incubator 4 and a housing container 5 (second auxiliary aseptic devices) each include a second auxiliary connection part 8 smaller than the first auxiliary connection part 7. In addition, an external blockage member 9 configured to externally block the opening O of the main connection part 6 is provided.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: August 18, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Tetsuya Nishimura, Kazuhito Tanimoto
  • Patent number: 10717553
    Abstract: A filling system includes a conveyance chamber in which a center wheel for conveying vessels is housed inside, a filling chamber where filling machines are housed inside, an inlet/outlet wheel that transfers the vessels from the center wheel to the filling machine, an opening that allows conveyance of the vessels, and a shutter that closes the opening. The inlet/outlet wheel includes grippers configured from a fixed section and a movable section. The movable section can be raised or lowered with respect to the rotational axis of the inlet/outlet wheel. When the shutter closes the opening, movable section is raised or lowered by a predetermined amount relative to the fixed section, after which the movable section is rotated by a predetermined amount to a position where it does not interfere with the shutter.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: July 21, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Yukinobu Nishino, Katsunori Tanikawa, Koji Kaya, Kengo Ikeda, Shigeki Koishi, Masaaki Eda
  • Patent number: 10647955
    Abstract: An operation isolator forms an aseptic space. An incubator is connected to the operation isolator, in which cells are stored and cultured. A storage chamber stores articles used in the operation isolator. In order to carry articles from the outside into the storage chamber, a decontamination pass-box is provided. The storage chamber and the operation isolator are directly or indirectly connected to each other.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: May 12, 2020
    Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, BIOMEDICA SOLUTIONS CO., LTD., SHIBUYA CORPORATION
    Inventors: Hideki Taniguchi, Takanori Takebe, Keisuke Sekine, Atsushi Nakao, Takashi Hiromatsu, Hironobu Sunayama, Tetsuya Nishimura
  • Patent number: 10604356
    Abstract: An article conveying device 4 includes a movable conveyer 12 for conveying a culture vessel 3 (article) and longitudinal mover 13b for moving the movable conveyer 21, and a conveyer driving motor 14 is provided separately from the movable conveyer 12, and a driving magnet MA rotated by a driving shaft 32 driven by the conveyer driving motor 14 and a driven magnet MB provided on the movable conveyer 12 and connected to the driving magnet MA by a magnetic force in a non-contact manner are provided. A plurality of the driven magnets MB is provided along a moving direction of the movable conveyer 12 by the longitudinal mover 13b, and an interval between the plurality of the driven magnets MB is matched with a moving distance of the movable conveyer 12 by the longitudinal mover 13b.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: March 31, 2020
    Assignee: Shibuya Corporation
    Inventors: Kazuhito Tanimoto, Tetsuya Nishimura
  • Patent number: 10597174
    Abstract: A filling nozzle provided with a filling cylinder, an air-injection cylinder, and an air-supply unit. The filling cylinder is configured such that an auger rotates about the axis thereof to discharge powder through an opening provided at the lower end of the filling cylinder. The air-injection cylinder is fitted to the exterior of the filling cylinder to form an annular space between the filling cylinder and the air-injection cylinder. The air-supply unit supplies air in the annular space. A tip portion of the air-injection cylinder extends downward below the opening and has an air-discharge mouth formed in a tapered shape such that the tip portion has a diameter smaller than that of the opening.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: March 24, 2020
    Assignee: SHIBUYA CORPORATION
    Inventors: Tetsuya Seno, Masato Ohta
  • Publication number: 20190329985
    Abstract: A container conveyor system includes a first endless conveyor and a second endless conveyor. The first endless conveyor is provided with a plurality of neck grippers that holds the neck of a capped container and conveys the container held by the neck gripper by moving the neck gripper. The second endless conveyor is provided with a plurality of vertical grippers that comprises an upper grip member, which is liftable and abuts against the top of the cap of the container, and a support plate that supports the base of the container. The second endless conveyor conveys the container held by the upper grip member and the support plate by moving the vertical gripper. The container conveyor system conveys the container by transferring the container between the neck gripper and the vertical gripper.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 31, 2019
    Applicant: SHIBUYA CORPORATION
    Inventors: Yukinobu NISHINO, Koji KAYA, Kotaro MITSUTANI, Mitsuo HASHIMOTO, Noboru NISHIMURA
  • Publication number: 20190276166
    Abstract: A filling system includes a conveyance chamber that conveys vessels, a filling chamber provided with a filling head that fills content into the vessels, a pressure control means that controls the pressure conditions of each chamber, an intermediate chamber that is provided between the conveyance chamber and the filling chamber, and a shutter that can separate the conveyance chamber and the intermediate chamber. When the filling chamber is separated by the shutter, the pressure control means controls the pressure of the intermediate chamber to become lower than the pressure of the conveyance chamber and the filling chamber.
    Type: Application
    Filed: September 13, 2017
    Publication date: September 12, 2019
    Applicant: SHIBUYA CORPORATION
    Inventors: Yukinobu NISHINO, Katsunori TANIKAWA, Koji KAYA, Kengo IKEDA, Shigeki KOISHI, Masaaki EDA
  • Patent number: 10400206
    Abstract: A sterile work can be applied by a worker 29 to cells or the like through a glove 28 provided in an isolator 15. A work headset 31 outputting a work procedure of the sterile work vocally is prepared for the worker, and a check input device 39 is prepared for a checker 36. A management device 12 outputs the work procedure of the sterile work this time vocally to the work headset. When the fact that the worker has normally performed the sterile work this time is checked by the checker, and when the fact is input from the check input device to the management device, the management device performs the subsequent work procedure. Since the sterile work by the worker 29 can be monitored by the checker 36, a wrong work can be prevented from being performed.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: September 3, 2019
    Assignee: SHIBUYA CORPORATION
    Inventor: Kenji Yoneda
  • Publication number: 20190263544
    Abstract: A filling system includes a conveyance chamber in which a center wheel for conveying vessels is housed inside, a filling chamber where filling machines are housed inside, an inlet/outlet wheel that transfers the vessels from the center wheel to the filling machine, an opening that allows conveyance of the vessels, and a shutter that closes the opening. The inlet/outlet wheel includes grippers configured from a fixed section and a movable section. The movable section can be raised or lowered with respect to the rotational axis of the inlet/outlet wheel. When the shutter closes the opening, movable section is raised or lowered by a predetermined amount relative to the fixed section, after which the movable section is rotated by a predetermined amount to a position where it does not interfere with the shutter.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 29, 2019
    Applicant: SHIBUYA CORPORATION
    Inventors: Yukinobu NISHINO, Katsunori TANIKAWA, Koji KAYA, Kengo IKEDA, Shigeki KOISHI, Masaaki EDA
  • Publication number: 20190248638
    Abstract: A filling system includes a center wheel that conveys vessels, a first filler provided with a plurality of filling heads, a second filler provided with a plurality of filling heads and arranged downstream from the first filler, a first inlet wheel that receives the vessels from the center wheel and supplies the vessels to the first filler, and a second inlet wheel that receives the vessel from the center wheel and supplies the vessels to the second filler. Operation modes are switchable between a first operation mode that conveys the vessels to the first filler and a second operation mode that conveys the vessels to the second filler instead of conveying to the first filler by controlling the reception of the vessels at the first and second inlet wheels.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 15, 2019
    Applicant: SHIBUYA CORPORATION
    Inventors: Yukinobu NISHINO, Katsunori TANIKAWA, Koji KAYA, Kengo IKEDA, Shigeki KOISHI, Masaaki EDA
  • Publication number: 20190152754
    Abstract: A filling valve for filling liquid into a bottle is provided that comprises a nozzle having an outlet on its bottom end and a seat on its interior surface, a stem arranged inside the nozzle and having a plug provided on its outer periphery, a helical vane provided on the outer periphery of the stem for inducing a spiral flow, and a bevel with expanding diameter in the downward direction is provided at the bottom end of the stem. The filling valve is closed when the stem descends and the plug makes contact with the seat. The filling valve is opened when the stem ascends and the plug separates from the seat. The bevel is extended below the outlet when the plug is opened. The liquid revolved via the helical vane and ejected from the outlet is spread by the bevel toward a bottle finish or neck.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Applicant: SHIBUYA CORPORATION
    Inventors: Yukinobu NISHINO, Shinya KAMORI, Shunya OTA, Yuichi YONEMURA, Taro KITAYAMA, Katsunori TANIKAWA
  • Patent number: 10241380
    Abstract: A terahertz wave generator 1 includes a nonlinear crystal 4, which is capable of generating a terahertz wave TH, a pumping beam emitter 2, which emits a pumping beam L1, a seed beam emitter 3, which is disposed so as to be parallel to a nonlinear crystal 4 and emits a seed beam L2, a first total reflection mirror 17 and a second total reflection mirror 18, which successively reflect the seed beam L2 emitted from the seed beam emitter 3 to cause the seed beam L2 to be incident on the nonlinear crystal 4, and a convex lens 6, which collects the seed beam L2.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: March 26, 2019
    Assignee: SHIBUYA CORPORATION
    Inventors: Toshiaki Naka, Motoi Sasaki, Akito Tsuchiya
  • Patent number: 10220382
    Abstract: An isolator comprises a manipulation chamber isolated from the external atmosphere, a door for opening and closing a portal formed on the manipulation chamber, a linear guide mechanism for guiding a linear motion of a front-side edge of the door along the portal, and a rotation guide mechanism defining a rotation of the door about an axis coinciding with the front-side edge. The door is closed by positioning the front-side edge at the front side of the manipulation chamber, and the door is opened inward into the manipulation chamber by moving the front-side edge toward the back side while rotating the door about the front-side edge.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: March 5, 2019
    Assignee: SHIBUYA CORPORATION
    Inventor: Kanjun Yamamoto