Patents Assigned to Shijiazhuang Yiling Pharmaceutical Co., Ltd.
  • Patent number: 11059773
    Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 13, 2021
    Assignees: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yang Lv, Shiying Yang, Gengtao Liu, Dan Zhang, Xiuqi Bao, Ping Xie
  • Publication number: 20210078939
    Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
    Type: Application
    Filed: September 7, 2018
    Publication date: March 18, 2021
    Applicants: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yang LV, Shiying YANG, Gengtao LIU, Dan ZHANG, Xiuqi BAO, Ping XIE
  • Patent number: 10881704
    Abstract: The present invention involves the application of Semen Ziziphi Spinosae oil in the preparation of drugs for treating medicinal insomnia. Semen Ziziphi Spinosae oil has a therapeutic effect on insomnia caused by ephedrine, prednisone and other drugs, and Semen Ziziphi Spinosae oil that is prepared within the pressing temperature of 80 to 100° C. has the best efficacy for treating medicinal insomnia.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: January 5, 2021
    Assignee: SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yiling Wu, Shaohua Zhao, Meng Wang
  • Publication number: 20200398188
    Abstract: The disclosure provides a method for separating eighteen components in a traditional Chinese medicine composition, including: (1) preparing the traditional Chinese medicine composition into a total extract of the traditional Chinese medicine composition, separating by resin through sequentially eluting with water, 10% ethanol and 30% ethanol, and collecting the 30% ethanol eluate to obtain a 30% ethanol extract; (2) adding the 30% ethanol extract to a reverse phase silica gel ODS-AQ-HG, and separating in a medium pressure separation column to obtain differently numbered elution dry pastes; (3) dissolving the differently numbered elution dry paste with 30% methanol as a solvent, and passing the solution through a 0.45 ?m microporous membrane, carrying out a primary separation by high performance liquid chromatography and collecting chromatographic peaks with different retention times, and further purifying by high performance liquid chromatography; finally obtaining the components of eighteen components.
    Type: Application
    Filed: September 5, 2018
    Publication date: December 24, 2020
    Applicant: Shijiazhuang Yiling Pharmaceutical Co., Ltd.
    Inventors: Shuo SHEN, Chuangfeng ZHANG, Dan BI, Feng WEI, Yunbo SUN
  • Publication number: 20200390840
    Abstract: The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-?-D-glucopyranoside, quercitrin, matairesinol-4-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.
    Type: Application
    Filed: October 25, 2018
    Publication date: December 17, 2020
    Applicant: Shijiazhuang Yiling Pharmaceutical Co., Ltd.
    Inventors: Chuangfeng Zhang, Shuo Shen, Lianqiang Song
  • Publication number: 20200157042
    Abstract: The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
    Type: Application
    Filed: September 7, 2018
    Publication date: May 21, 2020
    Applicants: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yang LV, Shiying YANG, Gengtao LIU, Dan ZHANG, Xiuqi BAO, Ping XIE
  • Publication number: 20190201471
    Abstract: The present invention involves the application of Semen Ziziphi Spinosae oil in the preparation of drugs for treating medicinal insomnia. Semen Ziziphi Spinosae oil has a therapeutic effect on insomnia caused by ephedrine, prednisone and other drugs, and Semen Ziziphi Spinosae oil that is prepared within the pressing temperature of 80 to 100° C. has the best efficacy for treating medicinal insomnia.
    Type: Application
    Filed: September 9, 2016
    Publication date: July 4, 2019
    Applicant: SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yiling Wu, Shaohua Zhao, Meng Wang
  • Patent number: 9556154
    Abstract: The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of the pyrrole-substituted indolone derivative for treating receptor tyrosine kinase-mediated diseases, and to a pharmaceutical composition comprising compounds having such a structure for treating related diseases such as tumors.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: January 31, 2017
    Assignee: Shijiazhuang Yiling Pharmaceutical Co. Ltd.
    Inventors: Lihong Hu, Shaohua Zhao, Peng Liu, Xiangjun Li, Junyong An, Mengxia Zhou, Lili Zhang, Zijian Yao
  • Publication number: 20160347740
    Abstract: The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of the pyrrole-substituted indolone derivative for treating receptor tyrosine kinase-mediated diseases, and to a pharmaceutical composition comprising compounds having such a structure for treating related diseases such as tumors.
    Type: Application
    Filed: February 4, 2015
    Publication date: December 1, 2016
    Applicant: SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Lihong HU, Shaohua ZHAO, Peng LIU, Xiangjun LI, Junyong AN, Mengxia ZHOU, Lili ZHANG, Zijian YAO
  • Patent number: 9278087
    Abstract: (?)-(S)-3-(3?-hydroxy)-butylphthalide (a compound shown by Formula I) and an ester formed of the same and an acid are proved by experiments to be applicable to treatment and prevention of cerebral ischemic diseases and have a sleep-improving function. The acid refers to a pharmaceutically acceptable inorganic or organic acid. The inorganic acid refers to nitric acid, sulfuric acid, or phosphoric acid. In addition to an acid radical, the organic acid at least comprises at least one of an amino group, a hydroxyl group, and a carboxyl group. None of the compound shown by Formula I and the ester thereof is water-soluble. An ester generated from the compound and the acid further react with an acid or a base to generate a salt which is water-soluble and is used to prepare injection preparation. The experiment proves that the salt does not stimulate vessels.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: March 8, 2016
    Assignee: Shijiazhuang Yiling Pharmaceutical Co., Ltd.
    Inventors: Wei Wang, Yayao Zhou, Ya'nan Liu
  • Patent number: 8653298
    Abstract: The biphenyl acetate is biphenyl acetic ammonia butantriol salt, which is obtained by reacting biphenyl acetic acid with ammonia butantriol in organic solvent. The salt is adapted to be used for producing analgesic, anti-inflammatory and antithermic medicines.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: February 18, 2014
    Assignee: Shijiazhuang Yiling Pharmaceutical Co., Ltd.
    Inventors: Wei Wang, Wenzhan Chen