Patents Assigned to Shimadzu Corporation
  • Publication number: 20200305782
    Abstract: A measurement probe for preschoolers includes a fiber configured to irradiate a head of a subject with light, and a holder made of a metal or resin other than rubber. A tip surface of a tip of the fiber that contacts the head of the subject is flat, and a corner of a tip surface of the holder that contacts the head of the subject is chamfered.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 1, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Ayaka HORI
  • Publication number: 20200309653
    Abstract: An impact testing machine is configured. The impact testing machine includes: a testing machine body that applies a load having a prescribed speed to a test piece and conducts a test; a controller that controls the testing machine body; a video camera that photographs the test piece; and a pulse generator. The controller includes: a detection signal capturing unit that captures a detection signal of the load in a prescribed measurement sampling period; and a synchronizing signal output unit that outputs a sampling synchronizing signal that is synchronized with the measurement sampling period. The pulse generator includes: a photographing instruction signal generator that generates a photographing instruction signal by multiplying or dividing the sampling synchronizing signal, and outputs the photographing instruction signal to the video camera. The photographing instruction signal issues a photographing instruction to the video camera.
    Type: Application
    Filed: March 17, 2020
    Publication date: October 1, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Nobuyuki TOKUOKA
  • Publication number: 20200309735
    Abstract: The present invention provides a method for detecting a monoclonal antibody in a sample, the method comprising: (a) a step of capturing and immobilizing, in pores of a porous body, the monoclonal antibody in the sample; (b) a step of performing selective protease digestion of the monoclonal antibody for 30 min or longer by contacting the porous body having the monoclonal antibody immobilized thereon with nanoparticles having a protease immobilized thereon; and (c) a step of detecting a peptide fragment obtained by the selective protease digestion, using liquid chromatography mass spectrometry (LC-MS), wherein step (b) is carried out under stirring condition for 10 sec to 5 min in the initial reaction stage, and then under static condition. According to the present invention, the detection method of a monoclonal antibody using mass spectrometry is simplified and can be applicable to multisample analysis.
    Type: Application
    Filed: December 28, 2017
    Publication date: October 1, 2020
    Applicant: Shimadzu Corporation
    Inventors: Takashi Shimada, Noriko Iwamoto, Megumi Takanashi
  • Publication number: 20200309746
    Abstract: The method according to the present invention includes: a training sample measurement process (S1, S2) in which, for a food product belonging to the same kind as a determination target, a plurality of training samples individually labeled with a known state of quality are subjected to a measurement using a chromatograph mass spectrometer under the same analysis condition; a training sample data collection process (S3, S4) in which an index value related to the magnitude of a peak observed on an extracted ion chromatogram obtained by the measurement is acquired for each training sample, and the index value of the peak at each retention time common to the training samples is extracted; and a discrimination model creation process (S5-S7) in which a supervised training is performed to create a discrimination model, using, as the training data, the index value of the peak at each retention time common to the training samples acquired for each of the labeled training samples.
    Type: Application
    Filed: November 5, 2019
    Publication date: October 1, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Takero SAKAI
  • Publication number: 20200309748
    Abstract: Respective peaks detected on chromatograms created based on data obtained by conducting GC-MS analysis on a target sample are identified based on information stored in a compound database (S1, S2). A retention time list indicating relationships between compounds and measured peak retention times is created based on results of identification of the peak. Then a plurality of compounds in which the measured retention times are identical to each other or are within an allowable range are extracted and are combined into one group (S3, S4). A determination is made whether overlapping identifications exist by determining whether a single group includes a plurality of compounds (S5, S6). Retention times, mass spectrums, and confirmation ion ratio reference values stored in the compound database are used for the respective groups in which overlapping identifications are likely to exist so that a most likely compound candidate is selected (S7).
    Type: Application
    Filed: July 8, 2016
    Publication date: October 1, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Publication number: 20200311987
    Abstract: A reconstruction processing method. The method includes an image updating step (Step S2) of updating a reconstruction image by an iterative approximation method, and a weighting coefficient map updating step (Step S4). In the weighting coefficient map updating step, a weighting coefficient map relative to prior knowledge is generated from the reconstruction image obtained by updating an image in the image updating step (Step S2), and a weighting coefficient of the prior knowledge relative to each pixel is controlled in accordance with the weighting coefficient map, whereby a weighting coefficient map is updated. As described above, the weighting coefficient map relative to the prior knowledge is generated from the reconstruction image (during estimation) obtained by updating the image, and the weighting coefficient of the prior knowledge relative to each pixel is controlled in accordance with the weighting coefficient map.
    Type: Application
    Filed: March 11, 2016
    Publication date: October 1, 2020
    Applicant: Shimadzu Corporation
    Inventor: Kenta CHINOMI
  • Publication number: 20200306748
    Abstract: A container set including: a filter unit; and a closing unit that is attachable to and detachable from the filter unit. The filter unit includes: a housing having a sample introduction opening provided at one end, and a liquid discharging opening provided at the second end; and a filter fixed to the housing. The housing has a first joining part, and the closing unit has a second joining part configured to be joinable with the first joining part. The first joining part and the second joining part are configured such that the liquid discharging opening is spatially closed in a state in which the two joining parts are joined together. A space between the closing unit and the filter is made into a positive pressure relative to a pressure in the sample holding space by pushing the filter unit and the closing unit such that the distance therebetween is shortened.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 1, 2020
    Applicant: Shimadzu Corporation
    Inventors: Noriko IWAMOTO, Megumi TAKANASHI, Takashi SHIMADA
  • Patent number: 10788469
    Abstract: A mass spectrometry data processor (2) having a database (21) for storing respective pieces of mass spectrum data of various compounds together with names and mass spectrometry conditions of the compounds includes a mass spectrum data receiver (22) configured to receive input of mass spectrum data associated with a compound name and a mass spectrometry condition, a determination unit (25) configured to determine whether the mass spectrum data includes a mass peak satisfying a predetermined criterion, and a database registration unit (31) that registers, on the database, mass spectrum data determined to include the mass peak satisfying the predetermined criterion or mass spectrum data based on the mass spectrum data determined to include the mass peak satisfying the predetermined criterion together with a compound name and a mass spectrometry condition.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Yutaro Yamamura, Toshikazu Minohata
  • Patent number: 10786217
    Abstract: This X-ray phase-contrast imaging apparatus is equipped with a plurality of gratings and grating holders for holding the plurality of gratings. The plurality of gratings is arranged such that the extending direction of grating components of the plurality of gratings is oriented in a direction in which the positional displacement due to the grating holder becomes maximum in a plane orthogonal to an optical axis of the X-ray.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: September 29, 2020
    Assignee: Shimadzu Corporation
    Inventors: Akira Horiba, Taro Shirai, Takahiro Doki, Satoshi Sano, Naoki Morimoto
  • Patent number: 10786215
    Abstract: A portable X-ray imaging apparatus is prevented from losing a connection with a medical member when a detection element is set up in the proximity of the subject to carry out an X-ray imaging. The portable X-ray imaging apparatus 100 comprises an X-ray tube device 4 that irradiates an X-ray to a subject P, an X-ray receiver 6 that detects the X-ray that transmits the subject P, a housing 1b that houses the X-ray receiver 6 capable of being pulled out, and a control element 21 that provides an alarm to prompt paying attention based on the connecting information 30a relative to a connection of the medical member with the subject P.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Toshiaki Nakamura
  • Patent number: 10788465
    Abstract: In a main body of a filter apparatus, an internal space A corresponding to a flow path of gas is formed in an annular shape, and a filter material filled in the internal space A is disposed in an annular shape. For this reason, it is possible to keep a cross-sectional area of the filter material large when compared to a case in which the filter material is disposed in an elongated shape, reduce flow path resistance, and keep a speed (linear velocity) of gas passing through the inside of the filter material low. Further, it is possible to improve capturing efficiency of the filter material. In addition, one end edge of a flow path, and flow paths and are formed at one end of the main body.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: September 29, 2020
    Assignee: Shimadzu Corporation
    Inventors: Kiyonori Koga, Yasunori Terai
  • Patent number: 10790132
    Abstract: The present invention provides a time-of-flight mass spectrometer (TOFMS) taken measures for preventing a deterioration in accuracy caused at the time of transportation to an installation site.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yusuke Sakagoshi
  • Patent number: 10788466
    Abstract: Provided is a sample introduction system for sequentially introducing a plurality of samples into an analyzer 200, the system including: an auto-sampler 300 including a sampling needle 302 for suctioning a sample from each well 312 provided in a plate 311 placed on a sample rack 310 or from a sample container 313 placed in the well 312, and a needle drive mechanism 303 for driving the sampling needle 302 in horizontal and vertical directions; an operation section 10 for allowing a user to command the needle drive mechanism 303 to drive the sampling needle 302; and a display controller 28 for displaying, on a screen of a display section 30, an identification of the well 312 related to a reference point defined on the plate 311 in a correction process conducted by the user by manipulating the operation section 10 so as to operate the needle drive mechanism 303 so that the sampling needle 302 is transferred to a predetermined position serving as the reference point.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yusuke Midorikawa
  • Patent number: 10788799
    Abstract: An analyzing apparatus is disclosed that is capable of preventing an intentional or negligent interventional action on an analysis. An analyzing apparatus 1 is connected to a controlling computer 2 and performs a predetermined analysis according to a control instruction given through the controlling computer 2. The analyzing apparatus 1 includes an operation unit 11 for enabling a user to perform an input operation for controlling the analyzing apparatus 1. When the analyzing apparatus 1 is under control of the controlling computer 2, the input operation performed through the operation unit 11 is disabled.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yusuke Yokoi
  • Publication number: 20200300862
    Abstract: A microorganism identification method according to the present invention includes a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying which bacteria of serovar of Salmonella genus bacteria the microorganisms contained in the sample contain, based on the mass-to-charge ratio m/z, in which at least one of two types of ribosomal proteins S8 and Peptidylpropyl isomerase is used as the marker protein.
    Type: Application
    Filed: March 31, 2016
    Publication date: September 24, 2020
    Applicants: SHIMADZU CORPORATION, MEIJO UNIVERSITY
    Inventors: Hiroto TAMURA, Naomi YAMAMOTO, Teruyo KATO, Keisuke SHIMA, Shinji FUNATSU
  • Publication number: 20200300794
    Abstract: A thermal conductivity detector (TCD) includes: a detection channel through which a gas to be measured flows as a fluid; a thermal conduction part that has a filament provided at a position in the detection channel where the filament comes into direct contact with the fluid flowing through the detection channel, thereby conducting heat through the fluid flowing through the detection channel; and a detection circuit for detecting an electric signal based on a change in a voltage or a current of the filament. The thermal conduction part has a plurality of filament sections that are substantially parallel to a flow direction of the fluid flowing through the detection channel.
    Type: Application
    Filed: March 7, 2016
    Publication date: September 24, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Kazunori TAKAHASHI
  • Publication number: 20200300863
    Abstract: A microorganism identification method utilizing mass spectrometry is provided. More specifically, a method for identifying a phylotype of Cutibacterium acnes utilizing mass spectrometry is provided. The method includes a) a step for reading out a m/z value of a peak derived from a marker protein on a mass spectrum which is obtained by mass spectrometry of a sample containing microorganisms; and b) a step for judging whether the sample contains Cutibacterium acnes (C. acnes) based on the m/z value.
    Type: Application
    Filed: February 26, 2020
    Publication date: September 24, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Kanae TERAMOTO
  • Publication number: 20200303174
    Abstract: In a tandem mass spectrometer, when the measurement mode is switched between a positive ion measurement mode and a negative ion measurement mode, a DC offset voltage applied to a lens electrode to impart collision energy to an ion is temporarily switched to 0 V (S1). After being maintained at 0 V for a predetermined waiting time (S2), the voltage is changed to a DC offset voltage corresponding to a measurement mode which is used after the switching operation (S3). By such an operation, the voltage difference between the neighboring plate electrodes among the plate electrodes (171, 172, 173) included in the lens electrode can be decreased as compared to the case where the polarity of the DC offset voltage is immediately switched. Consequently, unintended electric discharge between the neighboring electrodes can be prevented.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 24, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Yusuke MIDORIKAWA
  • Publication number: 20200300698
    Abstract: An infrared spectrophotometer uses a configuration that allows notification of the appropriate replacement time for an electric heater. The infrared spectrophotometer is provided with an electric heater 1, a PWM control circuit 5, a state detection unit 61, and a notification processing unit 62. The electric heater 1 is a light source that irradiates infrared radiation. The PWM control circuit 5 carries out PWM control so that the current supplied to the electric heater 1 is constant. The state detection unit 61 detects the state of the electric heater 1 on the basis of the variation in the duty cycle during PWM control. The notification processing unit 62 reports the result of the detection by the state detection unit 61.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 24, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Shinya WAKUDA
  • Patent number: 10779779
    Abstract: A portable radiation imaging apparatus improves visibility while moving by arranging the supporting column in the low-position. A base 46 is at a bottom end of a supporting column 41 and is fixed to turntable 78. A surface holding bearing 60 has an inner ring 61 and an outer ring 62 between the turntable 78 and a bottom plate 79. The inner ring 61 of the surface holding bearing 60 is fixed to the turntable 78 and the outer ring 62 is fixed to the bottom plate 79. The turntable 78 revolves with the supporting column 41 around the revolving center C, as the center, of the supporting column 41 and the turntable 78. An idler element 65 has a first circumference 63 and a second circumference 64 is installed to a circumference of the surface holding bearing 60. The revolving-side stopper 81 and the fixing-side stopper 82 regulate the idler element 65.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: September 22, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Toru Hayakawa, Hajime Takemoto