Patents Assigned to SHIN NIHON SEIYAKU CO., LTD
  • Gene-modified coxsackievirus
    Patent number: 10076547
    Abstract: A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a mutated genome consisting of the genome of coxsackievirus B3 wild-type (CVB3-WT) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific microRNA (miRNA) is provided. The mutated genome is preferably further inserted with the region encoding GM-CSF in an expressible form.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: September 18, 2018
    Assignees: SHIN NIHON SEIYAKU CO., LTD, KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Kenzaburo Tani, Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara