Abstract: This invention relates to a new compound, epoxyvibsanin B, which can be used to treat an IL-12 overproduction-related disorder such as an inflammatory disease.
Abstract: The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
Type:
Grant
Filed:
June 15, 2000
Date of Patent:
May 7, 2002
Assignee:
Shionogi Bioresearch Corp.
Inventors:
Mitsunori Ono, Yumiko Wada, Beatrice Brunkhorst, Tadeusz Warchol, Wojciech Wrona, Dan Zhou, Nha Huu Vo, Stephen Gillies
Abstract: A cyanoguanidine compound of the following formula:
is disclosed. A cyanoguanidine compound of the present invention possess a high specificity for tumor cells. Also disclosed are methods for preparing a cyanoguanidine compound.