Patents Assigned to Siemens Healthcare Diagnostics Inc.
  • Patent number: 10850280
    Abstract: Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Patent number: 10852266
    Abstract: The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and inexpensive construction, preferably with only a single membrane coating on an electrode. The invented devices are potentiometric salt-bridge reference electrodes and dissolved gas sensors constructed with a heterogeneous membrane coating of a conductor. The heterogeneous membrane, which is an intimate admixture of a hydrophobic and a hydrophilic compartment, concurrently supports constrained transport of non-volatile species through its hydrophilic compartment and rapid gas and water vapor transport through its hydrophobic compartment.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Imants Lauks, Anca Varlan, Alexandra Oussova, Michael Bales
  • Patent number: 10851428
    Abstract: The present invention is based in part on the present inventors' appreciation that certain sequences within an HIV genome are more likely to successfully detect HIV across a breadth of HIV variants. The ability to detect and/or quantify the presence and/or load of HIV in a subject is important to, among other things, the diagnosis and treatment of infected individuals. The present invention is based, in part, on the discovery of oligonucleotide reagents that detectably amplify sequences from a greater breadth of HIV samples than certain prior reagents and/or that generate amplicons from HIV genomes from which certain prior reagents would not have generated amplicons. Oligonucleotide reagents as described herein provide unexpected benefits in the detection and/or quantification of the presence and/or load of HIV in a subject, and thereby in the diagnosis and treatment of HIV.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 1, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Sunil Pandit, Arejas Uzgiris, Lance Palmer
  • Publication number: 20200371086
    Abstract: Provided herein are quality control substances for use with a microscopy-based urine sediment analyzer. The quality control substances comprise a urine matrix and a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof. Methods of detecting the presence of an analyte in a urine sample from a subject, quality control substances for use in identifying the presence of one or more analytes in a urine sample from a subject, and the use of a cancer cell, an algae cell, a yeast cell, egg white, or any combination thereof in the manufacture of a quality control substance for use with a microscopy-based urine analyzer are also provided.
    Type: Application
    Filed: August 24, 2018
    Publication date: November 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Kausik Das
  • Publication number: 20200368746
    Abstract: Devices, kits, and methods for conducting a plurality of diagnostic assays on a patient's single liquid test sample within a single reaction cassette.
    Type: Application
    Filed: February 13, 2019
    Publication date: November 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Publication number: 20200363396
    Abstract: In the various illustrative embodiments herein, test devices are described with opposing sensor arrays and same side contacts.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 19, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jennifer A. Samproni, Todd Andrade, Marlene Shi
  • Publication number: 20200364591
    Abstract: The inventive concepts herein relate to performing block retrieval on a block to be processed of a urine sediment image. The method comprises: using a plurality of decision trees to perform block retrieval on the block to be processed, wherein each of the plurality of decision trees comprises a judgment node and a leaf node, and the judgment node judges the block to be processed to make it reach the leaf node by using a block retrieval feature in a block retrieval feature set to form a block retrieval result at the leaf node, and at least two decision trees in the plurality of decision trees are different in structures thereof and/or judgments performed by the judgment nodes thereof by using the block retrieval feature; and integrating the block retrieval results of the plurality of decision trees so as to form a final block retrieval result.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 19, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tian Shen, Juan Xu, Xiao Fan Zhang
  • Patent number: 10838454
    Abstract: A monitor-mounted status indicator light assembly is disclosed, including at least one status indicator light and a mounting bracket adapted for mounting on a monitor. In some embodiments, standard VESA mounting configurations are employed, and the assembly's mounting bracket does not interfere with, or prevent, mounting of the monitor to a monitor mounting arm via the same VESA mounts.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 17, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Scott Salmon, Daniel LiCalzi, Daniel J. McDermott
  • Patent number: 10837973
    Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: November 17, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Niver Panosian Sahakian, Bruce A. Campbell, Spencer Hsiang-Hsi Lin, James Vincent Freeman, Qimu Liao, Ramon A. Evangelista
  • Patent number: 10829278
    Abstract: Embodiments are directed to a removable cap with a conduction seal closure for sealing an opening of a container. The cap has a side wall and a top wall with an open access hole there-through. A flat upper portion surrounds the open access hole, which is sealed by the conduction seal. The conduction seal comprises a first polymer sealing layer, an aluminum foil layer on top of the first layer to heat seal the first layer to the cap, and a second polymer layer arranged on top of the aluminum foil layer for protection. The aluminum foil provides a formable shaping strength such that upon seal piercing, a permanent memory spread of the first and third layers is achieved. Removal of the cap does not damage the seal. Access to the container contents is achieved without probe contact to the as-pierced seal.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: November 10, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: James W. Kegelman, Joseph E. Brennan, William E. Hudson
  • Patent number: 10829316
    Abstract: A system for transporting a carrier vehicle using linear motors comprising a linear motor housing shaped to hold one or more linear motors includes a rectangular top plate. A left side plate is connected adjacent to a first longitudinal edge of the rectangular top plate and a right side plate is connected adjacent to a second longitudinal edge of the rectangular top plate. The linear motor housing further includes a plurality of coupling components operable to couple the linear motor housing to one or more adjacent linear motor housings in a manner that facilitates continuous propulsion of the carrier vehicle across the rectangular top plate of the linear motor housing and rectangular top plates corresponding to the one or more adjacent linear motor housings.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 10, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Ilya Malyarov
  • Patent number: 10824832
    Abstract: Barcode tag conditions on sample tubes are detected utilizing side view images of sample tubes for streamlining handling in clinical laboratory automation systems. The condition of the tags may be classified into classes, each divided into a list of additional subcategories that cover individual characteristics of the tag quality. According to an embodiment, a tube characterization station (TCS) is utilized to obtain the side view images. The TCS enables the simultaneous or near-simultaneous collection of three images for each tube, resulting in a 360 degree side view for each tube. The method is based on a supervised scene understanding concept, resulting in an explanation of each pixel into its semantic meaning. Two parallel low-level cues for condition recognition, in combination with a tube model extraction cue, may be utilized. The semantic scene information is then integrated into a mid-level representation for final decision making into one of the condition classes.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: November 3, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Stefan Kluckner, Yao-Jen Chang, Wen Wu, Benjamin Pollack, Terrence Chen
  • Publication number: 20200340939
    Abstract: A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Brian Holman, Kevin Horan
  • Patent number: 10814322
    Abstract: In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates. Sensor assembly contains a first planar substrate having a base layer, and a conductive layer formed on a first planar surface of the base layer. Base layer may be made from, for example, ceramic, polymer, foil, or any other type of material known to someone of ordinary skill in the art. Conductive layer contains at least at least two electrically isolated electrical contacts made, for example, using a thick film approach (e.g., screen printing, rotogravure, pad printing, stenciling conductive material such as carbon, Cu, Pt, Pd, Au, and/or Nanotubes, etc.) or a thin firm approach (e.g., by sputtering, thermal spraying, and/or cold spraying conductive material).
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: October 27, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer A. Samproni
  • Patent number: 10816538
    Abstract: A model-based method of inspecting a specimen for presence of an interferent (H, I, and/or L). The method includes capturing images of the specimen at multiple different exposures times and at multiple spectra having different nominal wavelengths, selection of optimally-exposed pixels from the captured images to generate optimally-exposed image data for each spectra, identifying a serum or plasma portion of the specimen, and classifying whether an interferent is present or absent within the serum or plasma portion. Testing apparatus and quality check modules adapted to carry out the method are described, as are other aspects.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: October 27, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Stefan Kluckner, Yao-Jen Chang, Terrence Chen, Benjamin S. Pollack, Patrick Wissmann
  • Patent number: 10809264
    Abstract: A concentrated sample having enhanced concentration of the one or more different populations of target rare molecules is incubated with, for each different population of target rare molecules, a particulate or non-particulate affinity agent that comprises a specific binding partner that is specific for and binds to a target rare molecule. The affinity agent comprises a mass spectrometry (MS) label precursor or a first alteration agent, which either facilitates the formation of an MS label from the MS label precursor or releases an entity that comprises the MS label precursor from the affinity agent. The MS label corresponds to one of the populations of target rare molecules. A second alteration agent is employed if the first alteration agent does not facilitate the formation of an MS label from the MS label precursor. MS analysis is used to determine each different MS label.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: October 20, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael Pugia, Julia Philip, Karen Marfurt
  • Patent number: 10808244
    Abstract: The present disclosure relates to normalization of biological samples, particularly samples comprising nucleic acids to be sequenced. The normalization protocols described herein may be utilized across multiple samples to cap total stoichiometric input and minimize variations in transcript abundance on a per-sample basis in a multiplexed fashion to dramatically increase the accuracy, capacity and efficiency of nucleic acid sequencing.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 20, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Thomas Battersby, Adrian Nielsen Fehr, Minxue Zheng
  • Patent number: 10802034
    Abstract: Methods and apparatus configured and adapted to provide less carryover in an automated clinical analyzer are disclosed. The methods include aspirating a scavenger segment (e.g., a buffer- and surfactant-containing segment) into the interior of a pipette along with the specimen or reagent. The scavenger film aids in preventing adherence of the specimen or reagent to the interior of the pipette. Apparatus configured to carry out the methods are provided, as are other aspects.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: October 13, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Carl Gebauer, Moses Peter
  • Publication number: 20200300772
    Abstract: The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the analyte and an infra-red reference dye is measured at two preset times after a urine sample has been applied to a test strip and used to determine whether the reagents have been compromised by excessive humidity. The presence of unusually dark samples is determined from the reflected light at 470 and 625 nm in order to confirm that the test strips are humidity-compromised.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 24, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris T. Zimmerle, Michael J. Pugia
  • Publication number: 20200286621
    Abstract: A point of care system may comprise a plurality of diagnostic engines and an IDM in electronic communication with each of the plurality of diagnostic engines. Each of the plurality of diagnostic engines may perform testing on a sample inserted into the diagnostic engine. The IDM may be configured to communicate with each of the plurality of diagnostic engines to enable a plurality of tests to be performed on multiple different samples substantially simultaneously by a plurality of users using the plurality of diagnostic engines and to present a single user interface for managing testing by the plurality of diagnostic engines and for receiving the results of tests performed by each of the plurality of diagnostic engines.
    Type: Application
    Filed: November 16, 2018
    Publication date: September 10, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Karen Lim, Prabhu Ramachandran